Methods and demographic findings of the baseline survey of the NEDICES cohort: a door-to-door survey of neurological disorders in three communities from Central Spain

Morales, José Manuel; Bermejo, F; Benito‐León, Julián; Rivera‐Navarro, Jesús; Trincado, Rocío; Vega, Saturio

doi:10.1016/j.puhe.2003.10.007

Cited by 107 publications

(115 citation statements)

References 20 publications

(8 reference statements)

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“…4 Study protocol was approved by the local ethics institution and all subjects signed an informed consent at enrolment. Detailed of the study population and sampling methods have been published elsewhere.…”

Section: Study Populationmentioning

confidence: 99%

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Association between Parkinson's disease and diabetes: Data from NEDICES study

et al. 2017

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Section: Study Populationmentioning

confidence: 99%

“…Detailed of the study population and sampling methods have been published elsewhere. [4][5][6] Briefly, subjects were selected by means of census lists from three different populations in central Spain in 1994-1995. Data from this baseline cross-sectional evaluation were used for this study.…”

Section: Study Populationmentioning

confidence: 99%

Association between Parkinson's disease and diabetes: Data from NEDICES study

et al. 2017

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“…Data for these analyses were derived from the Neurological Disorders in Central Spain (NEDICES) study, a longitudinal, population-based survey of the prevalence, incidence, and determinants of major ageassociated conditions of the elderly, including Parkinson's disease, essential tremor, stroke, and dementia [16][17][18][19][20][21][22][23][24][25]. Detailed accounts of the study population and sampling methods have been published [23][24][25].…”

Section: Study Populationmentioning

confidence: 99%

“…Detailed accounts of the study population and sampling methods have been published [23][24][25]. The study population was composed of elderly subjects, 65 years old, living in three communities in central Spain (Las Margaritas, Lista, and Arévalo).…”

Section: Study Populationmentioning

confidence: 99%

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Statins and Cognitive Functioning in the Elderly: A Population-Based Study

Benito-León

Louis

Vega³

et al. 2010

JAD

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Abstract. In a 2009 Cochrane review, the authors concluded that there is good evidence that statins, given in late life to people at risk of vascular disease, have no effect in preventing Alzheimer's disease or dementia. A related issue, which remains unclear, is whether statins improve cognitive function. While some studies have shown a beneficial effect of statins on cognitive function, others have observed mild detrimental effects on cognition. Our aim was to assess cognitive function in community-dwelling elderly participants treated with statins compared with their untreated counterparts (i.e., controls) living in the same population. 137 population-dwelling participants who were receiving statins and 411 matched controls age 65 years (median = 72 years) in central Spain (the Neurological Disorders in Central Spain [NEDICES] study) underwent a neuropsychological assessment, including tests of global cognitive performance, frontal-executive function, verbal fluency, and memory. Median duration of statin treatment was 2 years. Of 137 participants receiving statins, 53 (38.7%) were taking pravastatin, 38 (27.7%) simvastatin, 37 (27.0%) lovastatin, 6 (4.4%) fluvastatin, and 3 (2.2%) atorvastatin. Although initial univariate analyses indicated some differences, after adjusting for age, gender, education, depressive symptoms, premorbid intelligence, medications that potentially affect cognitive function, and blood cholesterol levels, statin users and controls performed similarly on all neuropsychological tests. In this population-based sample, elderly participants treated with statins and untreated controls performed similarly in all tested cognitive areas. These results do not support a positive benefit of statins on cognition.

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