Methodology and Strategies for Companies in the Process of Internationalization

JG, Vargas Hernandez; OZ2, Alejandro

doi:10.4172/2375-4389.1000224

Cited by 1 publication

(2 citation statements)

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“…Yet, in other HSBM methods with different peptide catalysts, such as 6.23 and 6.24, much improved yields of 62-64% were observed, complimented by good anti-selectivities of 84:16-96:4 dr and enantioselectivities up to 57% ee (Figure 101b). 285,286 However, these ee values are significantly lower than those measured for the reaction with 4-nitrobenzaldehyde (see Figures 6.2c & 6.3c)…”

Section: Expansion Of Substrate Scopementioning

confidence: 62%

“…284 Using a related mechanochemical technique, Juaristi and co-workers have found that a series of dipeptides 6.23-6.25 (Figure 99c) can also be used to catalyze asymmetric aldol reactions with good yields (50-82%) and enantioselectivities (34-69% ee). [285][286][287] For the catalysts bearing aromatic sidechains (e.g., 6.23 & 6.24), the authors have speculated that noncovalent π-π interactions between the aromatic motif and the aromatic aldehyde could contribute to the high enantioselectivities observed. In comparison to the reactions with acetone under ball-milling conditions, catalysts 6.23-6.25 and 6.30 mediated highly diastereoselective aldol reactions with cyclohexanone as the donor, delivering the aldol products in up to 98% yield, 98:2 dr favoring anti, and >98% ee (Figure 100c).…”

Section: 4)mentioning

confidence: 99%

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Asymmetric Catalysis Mediated by Synthetic Peptides, Version 2.0: Expansion of Scope and Mechanisms

et al. 2020

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Low molecular weight synthetic peptides have been demonstrated to be effective catalysts for an increasingly wide array of asymmetric transformations. In many cases, these peptide-based catalysts have enabled novel multifunctional substrate activation modes and unprecedented selectivity manifolds. These features, along with their ease of preparation, modular and tunable structures, and often biomimetic attributes make peptides well-suited as chiral catalysts, and of broad interest. Many examples of peptide-catalyzed asymmetric reactions have appeared in the literature since the last survey of this broad field in Chemical Reviews (Chem. Rev. 2007, 107, 5759-5812). The overarching goal of this new review is to provide a comprehensive account of the numerous advances in the field. As a corollary to this goal, we survey the many different types of catalytic reactions, ranging from acylation to C-C bond formation, in which peptides been successfully employed. In so doing, we devote significant discussion to the structural and mechanistic aspects of these reactions that are perhaps specific to peptide-based catalysts and their interactions with substrates and/or reagents.

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Section: Expansion Of Substrate Scopementioning

confidence: 62%