Methodology and Baseline Characteristics for the Sarcopenia and Hip Fracture Study: A 5-Year Prospective Study

Singh, Maria A. Fiatarone; Singh, Nalin; Hansen, Ross; Finnegan, Terence P; Allen, Barry J.; Diamond, Terrence; Diwan, Ashish D.; Lloyd, Bradley D.; Williamson, Dominique A.; Smith, Emma; Grady, Jodie N.; Stavrinos, Theodora M.; Thompson, Martin W.

doi:10.1093/gerona/glp002

Cited by 72 publications

(37 citation statements)

References 35 publications

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“…However, as the intervention is home-based and individually targeted and the main outcomes can be assessed at the participants' home, we trust that the additional drop-out will be small. The demographics of our study participants is comparable to earlier studies involving community-dwelling older people recovering from hip fracture; the majority of them are women and the mean age is close to 80 [57]. …”

Section: Discussionsupporting

confidence: 58%

Promoting mobility after hip fracture (ProMo): study protocol and selected baseline results of a year-long randomized controlled trial among community-dwelling older people

Sipilä

Salpakoski

Edgren

et al. 2011

BMC Musculoskelet Disord

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BackgroundTo cope at their homes, community-dwelling older people surviving a hip fracture need a sufficient amount of functional ability and mobility. There is a lack of evidence on the best practices supporting recovery after hip fracture. The purpose of this article is to describe the design, intervention and demographic baseline results of a study investigating the effects of a rehabilitation program aiming to restore mobility and functional capacity among community-dwelling participants after hip fracture.Methods/DesignPopulation-based sample of over 60-year-old community-dwelling men and women operated for hip fracture (n = 81, mean age 79 years, 78% were women) participated in this study and were randomly allocated into control (Standard Care) and ProMo intervention groups on average 10 weeks post fracture and 6 weeks after discharged to home. Standard Care included written home exercise program with 5-7 exercises for lower limbs. Of all participants, 12 got a referral to physiotherapy. After discharged to home, only 50% adhered to Standard Care. None of the participants were followed-up for Standard Care or mobility recovery. ProMo-intervention included Standard Care and a year-long program including evaluation/modification of environmental hazards, guidance for safe walking, pain management, progressive home exercise program and physical activity counseling. Measurements included a comprehensive battery of laboratory tests and self-report on mobility limitation, disability, physical functional capacity and health as well as assessments for the key prerequisites for mobility, disability and functional capacity. All assessments were performed blinded at the research laboratory. No significant differences were observed between intervention and control groups in any of the demographic variables.DiscussionTen weeks post hip fracture only half of the participants were compliant to Standard Care. No follow-up for Standard Care or mobility recovery occurred. There is a need for rehabilitation and follow-up for mobility recovery after hip fracture. However, the effectiveness of the ProMo program can only be assessed at the end of the study.Trial registrationCurrent Controlled Trials ISRCTN53680197

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Section: Discussionsupporting

confidence: 58%

Promoting mobility after hip fracture (ProMo): study protocol and selected baseline results of a year-long randomized controlled trial among community-dwelling older people

Sipilä

Salpakoski

Edgren

et al. 2011

BMC Musculoskelet Disord

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“…During the past decade, it has become evident that the increase in oxidative stress with aging is a fundamental pathogenetic mechanism of age-related bone loss (4) and also possibly sarcopenia (5, 6)—2 important determinants that contribute to the risk of fracture (7–9). Research suggests a progressive decrease in both bone and muscle mass by 1–2%/y after the age of 50 y (5).…”

Section: Introductionmentioning

confidence: 99%

Intake and serum concentrations of α-tocopherol in relation to fractures in elderly women and men: 2 cohort studies

Michaëlsson¹,

Wolk²,

Byberg³

et al. 2014

The American Journal of Clinical Nutrition

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Background: A reduction in the formation of free radicals and oxidative stress might reduce the rate of bone loss and muscle wasting.Objective: The objective was to determine whether α-tocopherol intake or serum concentrations are associated with fracture risk in older women and men.Design: Two cohort studies, the Swedish Mammography Cohort (SMC; n = 61,433 women) and the Uppsala Longitudinal Study of Adult Men (ULSAM; n = 1138 men), were used.Results: During 19 y of follow-up, 14,738 women in the SMC experienced a first fracture at any site (3871 hip fractures). A higher hip fracture rate was observed with lower intakes of α-tocopherol. Compared with the highest quintile of intake, the lowest quintile had a multivariable-adjusted HR of 1.86 (95% CI: 1.67, 2.06). The HR of any fracture was 1.20 (95% CI: 1.14, 1.28). α-Tocopherol–containing supplement use was associated with a reduced rate of hip fracture (HR: 0.78; 95% CI: 0.65, 0.93) and any fracture (HR: 0.86; 95% CI: 0.78, 0.94). Compared with the highest quintile of α-tocopherol intake in ULSAM (follow-up: 12 y), lower intakes (quintiles 1–4) were associated with a higher rate of hip fracture (HR: 3.33; 95% CI: 1.43, 7.76) and any fracture (HR: 1.84; 95% CI: 1.18, 2.88). The HR for hip fracture in men for each 1-SD decrease in serum α-tocopherol was 1.58 (95% CI: 1.13, 2.22) and for any fracture was 1.23 (95% CI: 1.02, 1.48).Conclusion: Low intakes and low serum concentrations of α-tocopherol are associated with an increased rate of fracture in elderly women and men.

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“…Regular physical activity has been associated with better outcomes in the post-hip-fracture period (Fiatarone Singh et al, 2009; Zidén, Frändin, & Kreuter, 2008). Early findings from the Sarcopenia and Hip Fracture study (Fiatarone Singh et al, 2009), for example, suggest that individuals who are less sedentary before sustaining hip fractures tend to have shorter acute-care lengths of stay.…”

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confidence: 99%

Physical Activity in the Post-Hip-Fracture Period

Resnick

Galik

Boltz

et al. 2011

Journal of Aging and Physical Activity

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The purpose of this study was to characterize physical activity (PA) based on survey and ActiGraphy data from older adults at 2 mo post–hip fracture and consider the factors that influence PA among these individuals. The sample included participants from a current Baltimore hip study, the BHS-7. Measurement of PA was based on the Yale PA Survey (YPAS) and 48 hr of ActiGraphy. The sample included the first 200 individuals enrolled in the study, with analyses including 117 individuals (59%) who completed the YPAS and wore the ActiGraph for 48 hr. Half the participants were male, with an overall mean age of 81.3 yr (SD = 7.9). Findings indicate that at 2 mo post–hip fracture participants were engaged in very limited levels of PA. Age and comorbidities were the only variables to be significantly associated with PA outcomes.

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Methodology and Baseline Characteristics for the Sarcopenia and Hip Fracture Study: A 5-Year Prospective Study

Cited by 72 publications

References 35 publications

Promoting mobility after hip fracture (ProMo): study protocol and selected baseline results of a year-long randomized controlled trial among community-dwelling older people

Promoting mobility after hip fracture (ProMo): study protocol and selected baseline results of a year-long randomized controlled trial among community-dwelling older people

Intake and serum concentrations of α-tocopherol in relation to fractures in elderly women and men: 2 cohort studies

Physical Activity in the Post-Hip-Fracture Period

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