Methodologies and limitations in the analysis of potential neuroprotective compounds derived from natural products

Weber, John T.

doi:10.1016/j.nhtm.2015.01.001

Cited by 2 publications

(1 citation statement)

References 34 publications

(58 reference statements)

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“…However, under pathological conditions, excessive production of ROS and reactive nitrogen species leads to oxidative stress and nitrosative stress, respectively. Both types of stress damage lipids, proteins, and DNA and lead to the destruction of membranes and organelles (Weber, 2015). As mentioned earlier, some Convolvulaceae species exhibit neuroprotective activities in specific CNS disorder models.…”

Section: Neuroprotective Activitymentioning

confidence: 93%

Medicinal uses, pharmacology, and phytochemistry of Convolvulaceae plants with central nervous system efficacies: A systematic review

Chen

Liu

Yang

et al. 2018

Phytotherapy Research

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Central nervous system (CNS) disorders play a major impact on individual lives and place a severe strain on health care resources. Convolvulaceae is a family comprising approximately 1,600-1,700 species grouped in 55-60 genera, and many species are reported to have an effect on CNS functions. A systematic review of the literature studies was carried out to summarize available evidences on Convolvulaceae plants with CNS efficacies. This review is based on various data sources such as Google Scholar, Web of Science, Scopus, PubMed, and Wanfang Data. A total of 200 related articles were included in this review. According to the research result, 54 Convolvulaceae species are suggested to display CNS efficacies historically, and 46 species have been evaluated for their CNS efficacies. In addition, 67 compounds from 16 Convolvulaceae species are recognized to possess CNS efficacies. Despite great progress made through pharmacology and phytochemistry studies on CNS active Convolvulaceae species, more exploratory research is needed to gain a better understanding of the CNS efficacies of this plant family.

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Section: Neuroprotective Activitymentioning

confidence: 93%

Medicinal uses, pharmacology, and phytochemistry of Convolvulaceae plants with central nervous system efficacies: A systematic review

Chen

Liu

Yang

et al. 2018

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

Biochemical Properties and Neuroprotective Effects of Compounds in Various Species of Berries

2017

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Several species of berries, such as blueberries (Vaccinium angustifolium) and lingonberries (Vaccinium vitis-idaea L.), have attracted much scientific attention in recent years, especially due to their reported antioxidant and anti-inflammatory properties. Berries, as with other types of plants, have developed metabolic mechanisms to survive various environmental stresses, some of which involve reactive oxygen species. In addition, the fruits and leaves of berries have high amounts of polyphenols, such as flavonoids, which act as potent antioxidants. These compounds could potentially be beneficial for brain aging and neurodegenerative disorders. There are now several studies documenting the beneficial effects of various berries in cell models of neurotoxicity as well as in vivo models of neurodegenerative disease. In the current review, we discuss the metabolic strategies that plants and animals have developed in order to combat reactive oxygen species. We then discuss issues of bioavailability of various compounds in mammals and provide a synopsis of studies demonstrating the neuroprotective ability of berries and polyphenols. We also summarize findings from our own research group. For example, we have detected various polyphenols in samples of blueberries and lingonberries and have found that the leaves have a much higher antioxidant capacity than the fruits. Extracts from these species have also demonstrated neuroprotective effects in cellular models of toxicity and inflammation, which are being further pursued in animal models.

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Methodologies and limitations in the analysis of potential neuroprotective compounds derived from natural products

Cited by 2 publications

References 34 publications

Medicinal uses, pharmacology, and phytochemistry of Convolvulaceae plants with central nervous system efficacies: A systematic review

Medicinal uses, pharmacology, and phytochemistry of Convolvulaceae plants with central nervous system efficacies: A systematic review

Biochemical Properties and Neuroprotective Effects of Compounds in Various Species of Berries

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