The execution of businesses today has been significantly transformed by the Internet technology. Furthermore, in representing the electronic concepts and applications, a lot of terms have been introduced in signifying the revolution of processes and transactions associated with business. E-Business and e-Commerce are among these fairly new coined terms. In the context of Malaysia, the adoption of e-Business can be seen among diverse bodies including large organizations, and small, medium and micro enterprises. For a company, the implementation of e-Business would considerably alter its structure, culture, strategy, procedures and accountabilities as well, which can pose a significant challenge. Still, people remain keen in venturing into this novel concept of business. Accordingly, a mixed-method study was carried out to examine the e-Business prospect of home-based Malaysian micro sized businesses. Business and Homeworker business issues are reviewed, while preliminary study findings are reported in this study.