Methodological pitfalls in early detection studies – the NAPE Lecture 2002

Friis, Svein; Larsen, Tor Ketil; Melle, Ingrid; Opjordsmoen, Stein; Johannessen, J. O.; Haahr, Ulrik; Simonsen, Erik; Rund, Bjørn Rishovd; Vaglum, Per; McGlashan, Thomas H.

doi:10.1034/j.1600-0447.2003.02600.x

Cited by 83 publications

(72 citation statements)

References 34 publications

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“…The raters were blind to all the ratings at both points. For all dimensions, the reliability was clearly satisfactory [19] . For diagnosis: = 0.81; for the other dimensions ICCs (1.1) were: GAF function: 0.86, GAF symptoms: 0.91, alcohol: 0.75 and drugs: 0.86.…”

Section: Methodsmentioning

confidence: 95%

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First-Episode Psychosis: Diagnostic Stability over One and Two Years

Haahr

Friis²,

Larsen³

et al. 2008

Psychopathology

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Background: Diagnostic stability is important for daily clinical work and planning of treatment. The aims of this study were to measure diagnostic stability in a clinical epidemiologic sample and to identify markers of change in diagnosis. Sampling and Methods: Diagnostic stability and change were measured in a sample of 301 patients with first-episode psychosis from four national health care sectors in Norway and Denmark at baseline, 1 and 2 years. Results: Diagnostic stabilities were high for schizophrenia and schizoaffective disorder (85–99%), low for schizophreniform disorder (16–19%), and intermediate for other diagnoses. Diagnostic change from schizophreniform to schizophrenia was frequent in year 1 (72%). Characteristics discriminating schizophreniform patients keeping their diagnosis (i.e. having recovered within 6 months with no relapse) from those developing schizophrenia at 1 year were female gender, better childhood premorbid functioning, shorter duration of untreated psychosis and more severe general psychotic symptoms, especially excitation. Conclusions: Findings provide validation for the DSM-IV categories within the schizophrenic spectrum. The limitations of the study were: the raters were not blind to baseline assessments; patients with longer duration of untreated psychosis were more likely to refuse participation; not all patients were assessed at 1- and 2-year follow-up, but the attrition was rather low.

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Section: Methodsmentioning

confidence: 95%

“…The percentage with core schizophrenia spectrum disorder at baseline in refusers was not significantly different from that of the included patients. For details, see Friis et al [19] . There were no significant differences between patients with and without complete data sets.…”

Section: Subjectsmentioning

confidence: 99%

First-Episode Psychosis: Diagnostic Stability over One and Two Years

Haahr

Friis²,

Larsen³

et al. 2008

Psychopathology

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“…26 Difficult evaluations were discussed in regular team meetings to arrive at consensus ratings. The Structured Clinical Interview for the DSM-IV Axis I Disorders was used for diagnostic purposes.…”

Section: Methodsmentioning

confidence: 99%

“…26 Reliability for the PANSS scores was measured by the rating of actual videotaped interviews of first-episode patients by all raters. Reliability for the diagnosis, GAF scores, and DUP was measured by the rating of actual case notes by masked raters (S.F.…”

Section: Methodsmentioning

confidence: 99%

Reducing the Duration of Untreated First-Episode Psychosis

Melle

Larsen²,

Haahr³

et al. 2004

Arch Gen Psychiatry

381

300

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“…The assessment teams consisted of the same raters throughout the study. Good reliability for all major variables (PANSS, DUP and diagnosis) was achieved [28] .…”

Section: Instruments and Measuresmentioning

confidence: 99%

Contrasting Monosymptomatic Patients with Hallucinations and Delusions in First-Episode Psychosis Patients: A Five-Year Longitudinal Follow-Up Study

Evensen

Røssberg

Haahr³

et al. 2011

Psychopathology

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time to remission and suicidality. Results: Two groups of patients were identified; H (n = 16) and D (n = 106). 179 patients experienced both hallucinations and delusions (dual symptom group). The H group was significantly younger, had a longer duration of untreated psychosis, poorer premorbid function and better insight than the D group. Notably, the H group scored higher on measures of suicidality, and at 5 years follow-up a significantly higher proportion of patients was lost to suicide in this group. The dual symptom group was closer to the D group on significant parameters, including suicidality and suicide rate. Conclusions: Patients with hallucinations only can be separated from patients with delusions only and the subgroups differ with regard to demographical data, clinical variables and notably with regard to suicidality. These findings suggest distinctions in the underlying biological and psychological processes involved in hallucinations and in delusions. Key WordsHallucinations ؒ Delusions ؒ Psychotic symptoms ؒ Suicide Abstract Background: The main aim of this study was to identify subgroups of patients characterized by having hallucinations only or delusions only and to examine whether these groups differed with regard to demographic characteristics, clinical characteristics and outcome factors, including suicidality. Methods: Out of 301 consecutively admitted patients with first-episode psychosis, individuals with delusions only (D) and hallucinations only (H) were identified based on Positive and Negative Syndrome Scale (PANSS) items P1 (delusions) and P3 (hallucinations) scores at baseline and through 4 follow-up interviews over 5 years. The subgroups were compared with regard to demographic data, premorbid functioning, duration of untreated psychosis, clinical variables,

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Methodological pitfalls in early detection studies – the NAPE Lecture 2002

Abstract: Methodological pitfalls may bias ED studies. Several pitfalls are unavoidable, but proper design and quality assurance can reduce their impact. Researchers ought to identify the pitfalls, and to estimate and discuss their influence.

Cited by 83 publications

References 34 publications

First-Episode Psychosis: Diagnostic Stability over One and Two Years

First-Episode Psychosis: Diagnostic Stability over One and Two Years

Reducing the Duration of Untreated First-Episode Psychosis

Contrasting Monosymptomatic Patients with Hallucinations and Delusions in First-Episode Psychosis Patients: A Five-Year Longitudinal Follow-Up Study

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