Methodologic approach for the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project

Namasté, Sorrel; Aaron, Grant J; Varadhan, Ravi; Peerson, Janet M; Suchdev, Parminder S.

doi:10.3945/ajcn.116.142273

Cited by 155 publications

(82 citation statements)

References 46 publications

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“… An increased ferritin cutoff for identifying ID from the commonly used 12–15 µg/L [ 128 ] to 30 or even 70 µg/L in the presence of human immunodeficiency virus (HIV) [ 129 ]. Utilisation of inflammation biomarkers (CRP and AGP) to adjust the data to allow for the degree of inflammation [ 84 , 85 , 130 ]. …”

Section: Diagnostics—correcting Iron Status For Inflammationmentioning

confidence: 99%

“…Utilisation of inflammation biomarkers (CRP and AGP) to adjust the data to allow for the degree of inflammation [ 84 , 85 , 130 ].…”

Section: Diagnostics—correcting Iron Status For Inflammationmentioning

confidence: 99%

“…Namaste et al [ 85 , 130 ] have suggested using a regression correction to adjust ferritin concentrations using CRP and AGP and malaria infection as the explanatory variables. Similar adjustments may be possible in different populations addressing a range of inflammatory conditions; however, this will require research with large study samples and validation in different populations.…”

Section: Diagnostics—correcting Iron Status For Inflammationmentioning

confidence: 99%

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Are Pregnant Women Who Are Living with Overweight or Obesity at Greater Risk of Developing Iron Deficiency/Anaemia?

et al. 2021

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Low-grade inflammation is often present in people living with obesity. Inflammation can impact iron uptake and metabolism through elevation of hepcidin levels. Obesity is a major public health issue globally, with pregnant women often affected by the condition. Maternal obesity is associated with increased pregnancy risks including iron deficiency (ID) and iron-deficiency anaemia (IDA)—conditions already highly prevalent in pregnant women and their newborns. This comprehensive review assesses whether the inflammatory state induced by obesity could contribute to an increased incidence of ID/IDA in pregnant women and their children. We discuss the challenges in accurate measurement of iron status in the presence of inflammation, and available iron repletion strategies and their effectiveness in pregnant women living with obesity. We suggest that pre-pregnancy obesity and overweight/obese pregnancies carry a greater risk of ID/IDA for the mother during pregnancy and postpartum period, as well as for the baby. We propose iron status and weight gain during pregnancy should be monitored more closely in women who are living with overweight or obesity.

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Section: Diagnostics—correcting Iron Status For Inflammationmentioning

confidence: 99%

“…Utilisation of inflammation biomarkers (CRP and AGP) to adjust the data to allow for the degree of inflammation [ 84 , 85 , 130 ].…”

Section: Diagnostics—correcting Iron Status For Inflammationmentioning

confidence: 99%

Section: Diagnostics—correcting Iron Status For Inflammationmentioning

confidence: 99%

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Are Pregnant Women Who Are Living with Overweight or Obesity at Greater Risk of Developing Iron Deficiency/Anaemia?

et al. 2021

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“…The primary outcome variable was child anaemia, defined as Hb < 11.0 g/dL for children 6-59 months old (World Health Organization, 2011). Iron deficiency, analysed as a secondary outcome, was defined as low SF (SF < 12 μg/L), indicative of low iron stores, or high sTfR (sTfR >8.3 mg/L), indicative of low availability of iron to tissues (Namaste et al, 2017). SF concentrations were adjusted for inflammation (CRP and AGP) using the regression correction approach outlined by Namaste et al (2017).…”

Section: Variable Definitionsmentioning

confidence: 99%

“…The number of times per month that ASF categories were consumed during the prior 3 months was also calculated, ranging from 0 to 62 times per month (if the food group was consumed at least twice per day in a 31-day month). Child morbidity indicators included whether or not the child had fever, diarrhoea or a cough or cold in the 7 days before the survey and whether the child had inflammation, defined as CRP > 5 mg/L or AGP > 1 g/L (Namaste et al, 2017). records.…”

Section: Variable Definitionsmentioning

confidence: 99%

Associations between livestock ownership and lower odds of anaemia among children 6–59 months old are not mediated by animal‐source food consumption in Ghana

Lambrecht

Wilson

Baylin

et al. 2021

Maternal & Child Nutrition

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Livestock ownership may mitigate anaemia among young children by providing access to animal-source foods (ASFs) yet exacerbate anaemia by exposing children to animal-source pathogens. This study aimed to assess the association between household livestock ownership and child anaemia and examine whether this relationship is mediated by child ASF consumption or by child morbidity and inflammation. We conducted a cross-sectional study of 470 children aged 6-59 months in Greater Accra, Ghana. Child blood samples were analysed for haemoglobin concentration, iron status biomarkers and inflammatory biomarkers. Caregivers were asked about the child's frequency of ASF consumption in the past 3 months. Livestock ownership was categorized into five typologies to distinguish households by the number and combinations of species owned. In adjusted logistic regression, children from households in Type 5, owning cattle, small livestock (goats, sheep or pigs) and poultry, had lower odds of anaemia compared with those in Type 1, owning no livestock (OR [95% CI]: 0.32 [0.14, 0.71]). Although children from households that owned poultry were more likely to consume chicken meat, and children from households with cattle were more likely to drink cow's milk, consumption of these ASFs did not mediate the observed association between livestock ownership and child anaemia. There were no associations between livestock ownership and children's symptoms of illness or inflammation. Further research is needed to understand how ownership of certain livestock species, or a greater diversity of livestock species, may be associated with the risk of child anaemia, including the role of dietary and income-based pathways.

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Efficacy of an iron‐fortified infant cereal to reduce the risk of iron deficiency anemia in young children in East Cameroon

Ekoe

Bianpambe

Nguefack

et al. 2020

Food Science & Nutrition

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Complementary foods in Africa are often poor sources of bioavailable iron. We assessed the efficacy of iron‐fortified wheat‐based infant cereal (IC) to reduce the risk of iron deficiency anemia in children aged 18–59 months in Cameroon. A 6‐month double‐blind, cluster‐randomized controlled trial was conducted in 2017 among anemic (hemoglobin 7–11 g/dl) but otherwise healthy children. In conjunction with usual diet, children received two 50 g servings/day of a standard, micronutrient‐fortified IC (providing 3.75 mg iron/serving; n = 106) or the same IC without iron fortification ( n = 99). Anthropometric measurements, blood sampling, and systematic deworming were performed in all children at baseline (pre‐intervention), 3, and 6 months. Mean hemoglobin, ferritin adjusted for C‐reactive protein (CRP), serum iron, transferrin saturation, prevalence of anemia, iron deficiency, and iron deficiency anemia as well as anthropometrics were compared between the groups at baseline, 3, and 6 months. Compared to the control group, children consuming the iron‐fortified IC had significantly higher baseline‐adjusted mean hemoglobin (10.0 ± 1.8 vs. 9.7 ± 1.4 g/dl, respectively; p = .023), ferritin adjusted for CRP (16.1 ± 8.3 vs. 9.5 ± 7.5 μg/L, p < .001), serum iron (14.5 ± 3.9 vs. 11.2 ± 4.4 μg/dl; p < .001), and transferrin saturation (19.0 ± 17.4 vs. 10.7 ± 12.5%; p ˂ .001) at 6 months. The prevalence of anemia, iron deficiency, and iron deficiency anemia at 6 months decreased by a larger extent in the iron‐fortified group versus controls (all p < .01). In addition, at 6 months, children in the iron‐fortified group demonstrated higher weight‐for‐age z ‐scores ( p = .016) compared to the control group. Wheat‐based IC fortified with 7.5 mg ferrous fumarate administered daily for 6 months improved iron and nutritional status and decreased the prevalence of iron deficiency anemia in children aged 18–59 months in Salapoumbé, Cameroon.

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Methodologic approach for the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project

Cited by 155 publications

References 46 publications

Are Pregnant Women Who Are Living with Overweight or Obesity at Greater Risk of Developing Iron Deficiency/Anaemia?

Are Pregnant Women Who Are Living with Overweight or Obesity at Greater Risk of Developing Iron Deficiency/Anaemia?

Associations between livestock ownership and lower odds of anaemia among children 6–59 months old are not mediated by animal‐source food consumption in Ghana

Efficacy of an iron‐fortified infant cereal to reduce the risk of iron deficiency anemia in young children in East Cameroon

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