Methode zur Bestimmung von Maleinsäurehydrazid-Rückständen im Tabak

Rastetter, Adolf; Burkart, Franz; Fischer, Kurt Gerhard

doi:10.1007/bf01810487

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“…This method successfully determined 1 ppm of maleic hydrazide in green tobacco leaves and secondary growth and in soil; with the latter no accumulation was shown to occur (Hoffman and Parups, 1972;. The method has also been used in Germany for analysis of maleic hydrazide in tobacco (Rastetter et al, 1974). Ion exchange resins have been used for processing aquatic samples for maleic hydrazide but recoveries were only 50% (Sorensen, 1971).…”

Section: Synthesismentioning

confidence: 95%

Maleic hydrazide: Should the Delaney amendment apply to its use?

Haley

1977

Journal of Toxicology and Environmental Health

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The chemistry, metabolism, toxicology, mutagenicity, and carcinogenicity of maleic hydrazide have been reviewed. There is little doubt that this chemical is a mutagen and a carcinogen in cell cultures and animals, but no evidence is available on human carcinogenicity regardless of population exposure in manufacturing, agriculture, and the food chain (i.e., potato chips). An epidemiology survey should be conducted to ascertain possible human carcinogenicity in these populations. A long-term ingestion experiment should be conducted in several animal species to establish whether maleic hydrazide is carcinogenic by this route. Biotransformation studies should be undertaken along with pharmacokinetic studies to obtain a better understanding of the chemical's metabolism and excretion. Such investigations would firmly establish whether the tolerance formaleic hydrazide should remain or whether the use of the compound should be banned under the Delaney Amendment.

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Section: Synthesismentioning

confidence: 95%

Maleic hydrazide: Should the Delaney amendment apply to its use?

Haley

1977

Journal of Toxicology and Environmental Health

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show abstract

Methode zur Bestimmung von Maleinsäurehydrazid-Rückständen im Tabak

Cited by 1 publication

References 1 publication

Maleic hydrazide: Should the Delaney amendment apply to its use?

Maleic hydrazide: Should the Delaney amendment apply to its use?

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