Method validation for the quantification of As, Cd, Hg and Pb in blood by ICP-MS for monitoring purposes

D’Ilio, Sonia; Majorani, Costanza; Petrucci, Francesco; Violante, N; Senofonte, Oreste

doi:10.1039/c0ay00429d

Cited by 20 publications

(11 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Blood is particularly useful in such studies as it can be obtained by non-lethal sampling. Moreover, although trace element concentrations are higher in tissues such as liver and kidney than in blood, modern atomic spectrometry techniques can determine metal concentrations at ng L -1 levels, so that blood is now considered a suitable analytical sample in biological and environmental monitoring studies [7,10–12]. Moreover, information regarding toxic elements in blood is important in clinical diagnostics in both humans and animals.…”

Section: Introductionmentioning

confidence: 99%

Validation of a simple sample preparation method for multielement analysis of bovine serum

et al. 2019

View full text Add to dashboard Cite

Here we propose a single acid digestion (SAD) sample preparation method for ICP-MS analysis of animal serum samples to determine trace element contents. The method was evaluated in comparison with a commonly used procedure involving dilution of samples in an alkaline solution (AKD). In the SAD procedure, aliquots (1 mL) of bovine serum samples were treated at low temperature with a mixture of concentrated nitric acid and hydrogen peroxide. Trace elements (As, B, Ba, Cd, Co, Cr, Cu, Fe, Hg, Li, Mn, Mo, Ni, Pb, Sb, Se, Sr, U, and Zn) were directly determined by ICP-MS analysis of diluted solutions of samples. Both methods were sufficiently sensitive to enable quantification of most trace elements, with the exception of the AKD method for Cd, Hg and Pb. The quality of the data was verified by using certified reference material. Good results were obtained for the SAD procedure and all elements, but recoveries were unacceptable with the AKD procedure for Se (recovery: 57%), Cd (154%) and Fe (139%). Strong associations (R2>0.90, P = 0.000) between the data obtained by both methods were demonstrated for the elements considered. The proposed SAD sample preparation method produced satisfactory results for determining most toxic and essential trace elements targeted in monitoring studies.

show abstract

Section: Introductionmentioning

confidence: 99%

Validation of a simple sample preparation method for multielement analysis of bovine serum

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Determination of these elements requires sufficiently sensitive techniques for detection at the g/L or sublevels. In the literature, there are many techniques including atomic absorption spectrometry (AAS) [15,16], graphite furnace atomic absorption spectrometry (GFAAS) [17,18], inductively coupled plasma optical emission spectrometry (ICP-OES) [19,20], and inductively coupled plasma mass spectrometry (ICP-MS) [21,22] for the determination of As, Pb, and Cd in different matrices. Although AAS has been used for many elements in variety of matrices [23,24], there is sensitivity problem for many elements in the case of using this instrument.…”

Section: Introductionmentioning

confidence: 99%

Determination of As, Cd, and Pb in Tap Water and Bottled Water Samples by Using Optimized GFAAS System with Pd-Mg and Ni as Matrix Modifiers

Bakırdere

Yaroğlu

Tırık

et al. 2013

Journal of Spectroscopy

View full text Add to dashboard Cite

Arsenic, lead, and cadmium were determined in tap and bottled water samples consumed in the west part of Turkey at trace levels. Graphite furnace atomic absorption spectrometry (GFAAS) was used in all detections. All of the system parameters for each element were optimized to increase sensitivity. Pd-Mg mixture was selected as the best matrix modifier for As, while the highest signals were obtained for Pb and Cd in the case of Ni used as matrix modifier. Detection limits for As, Cd, and Pb were found to be 2.0, 0.036, and 0.25 ng/mL, respectively. 78 tap water and 17 different brands of bottled water samples were analyzed for their As, Cd, and Pb contents under the optimized conditions. In all water samples, concentration of cadmium was found to be lower than detection limits. Lead concentration in the samples analyzed varied between N.D. and 12.66 ± 0.68 ng/mL. The highest concentration of arsenic was determined as 11.54 ± 2.79 ng/mL. Accuracy of the methods was verified by using a certified reference material, namely, Trace Element in Water, 1643e. Results found for As, Cd, and Pb in reference materials were in satisfactory agreement with the certified values.

show abstract

“…The trace element and Hg concentrations in digests were determined using an inductively coupled plasma mass spectrometer (ICP-MS; 7700x, Agilent Technologies, Santa Clara, USA). ICP-MS is an analytical technique commonly used to analyze Hg and other trace elements (D’Ilio et al 2010 ; Djedjibegovic et al 2012 ). Mercury and the other trace elements were measured separately with optimized operating parameters (Tab.…”

Section: Methodsmentioning

confidence: 99%

250-year records of mercury and trace element deposition in two lakes from Cajas National Park, SW Ecuadorian Andes

Schneider

Bandowe

Bigalke

et al. 2020

Environ Sci Pollut Res

View full text Add to dashboard Cite

Historical records of trace elements in lake sediments provide source-to-sink information about potentially toxic pollutants across space and time. We investigated two lakes located at different elevations in the Ecuadorian Andes to understand how trace element fluxes are related to (i) geology, (ii) erosion in the watersheds, and (iii) local point sources and atmospheric loads. In remote Lake Fondococha (4150 m a.s.l.), total Hg fluxes stay constant between ca. 1760 and 1950 and show an approximately 4.4-fold increase between pre-1950 and post-1950 values. The post-1950 increase in fluxes of other trace elements (V, Cr, Co, Ni, Cu, Zn, As, Cd, and Pb) is lower (2.1–3.0-fold) than for Hg. Mostly lithogenic sources and enhanced soil erosion contribute to their post-1950 increase (lithogenic contribution: > 85%, Hg: ~ 58%). Average post-1950 Hg fluxes are approximately 4.3 times higher in peri-urban Lake Llaviucu (3150 m a.s.l.) than in the remote Lake Fondococha. Post-1950 fluxes of the other trace elements showed larger differences between Lakes Fondococha and Llaviucu (5.2 < 25–29.5-fold increase; Ni < Pb–Cd). The comparison of the post-1950 average trace element fluxes that are derived from point and airborne sources revealed 5–687 (Hg–Pb) times higher values in Lake Llaviucu than in Lake Fondococha suggesting that Lake Llaviucu’s proximity to the city of Cuenca strongly influences its deposition record (industrial emissions, traffic, caged fishery). Both lakes responded with temporary drops in trace element accumulations to park regulations in the 1970s and 1990s, but show again increasing trends in recent times, most likely caused by increase in vehicular traffic and openings of copper and gold mines around Cajas National Park.

show abstract

Method validation for the quantification of As, Cd, Hg and Pb in blood by ICP-MS for monitoring purposes

Cited by 20 publications

References 37 publications

Validation of a simple sample preparation method for multielement analysis of bovine serum

Validation of a simple sample preparation method for multielement analysis of bovine serum

Determination of As, Cd, and Pb in Tap Water and Bottled Water Samples by Using Optimized GFAAS System with Pd-Mg and Ni as Matrix Modifiers

250-year records of mercury and trace element deposition in two lakes from Cajas National Park, SW Ecuadorian Andes

Contact Info

Product

Resources

About