Method of ε-caprolactone synthesis by chemo-enzymatic oxidation of cyclohexanone in emulsion

Sitko, Magdalena

doi:10.15199/62.2019.10.11

Cited by 1 publication

(3 citation statements)

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“…The synthesis of the simple lactones using chemical methods can be divided into cyclization, reduction and oxidation. In recent years, biocatalysts were also used for the synthesis of lactones, enabling the use of less harmful and more stable reagents [19]. The main methods for the preparation of lactones are presented in Scheme 3.…”

Section: Methods For the Synthesis Of Lactonesmentioning

confidence: 99%

“…The proper oxidant, percarboxylic acid, is formed in situ and immediately oxidizes the cyclohexanone present in the reaction medium while the carboxylic acid is once again oxidised in the reaction mixture. The reaction takes place under the mild conditions (Scheme 4) [19]. ε-caprolactone can be obtained in the presence of acidic ionic liquids as a catalyst and a urea complex with hydrogen peroxide as the oxidant.…”

Section: Methods For the Synthesis Of Lactonesmentioning

confidence: 99%

“…The lack of an oligomerization inhibitor results in OCL synthesis, thus the transition from the substrates, i.e., cyclohexanone and hydrogen peroxide to the oligomer itself, actually takes place in one vessel. Moreover, this method is characterized by mild reaction conditions (low temperature and atmospheric pressure) and the absence of environmentally harmful initiators or catalysts containing heavy metals [19].…”

Section: Methods For the Synthesis Of Lactones Derivativesmentioning

confidence: 99%

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Recent Developments in Lactone Monomers and Polymer Synthesis and Application

2021

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Lactones are a group of compounds that have been known for several decades. The commercial importance of lactones results from the possibility of manufacturing of a broad scope of derivatives and polymers with a wide spectrum of applications. In this work the synthesis and characterization of simple lactones are described, which due to the easy methods of the synthesis are of high importance for the industry. The chemical as well as biochemical methods are included with special attention paid to the methods that avoid metal catalysts, initiators or toxic solvents, allowing the use of the final products for the medical applications, e.g., for controlled drug-release systems, resorbable surgical threads, implants, tissue scaffolds or for the production of drugs. Lactone-based derivatives, such as polymers, copolymers, composites or three-dimensional structures are also presented. The work is focused on the methods for the synthesis of lactones and lactones derivates, as well as on the special properties and application of the studied compounds.

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Section: Methods For the Synthesis Of Lactonesmentioning

confidence: 99%

Section: Methods For the Synthesis Of Lactonesmentioning

confidence: 99%

Section: Methods For the Synthesis Of Lactones Derivativesmentioning

confidence: 99%

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