Method of Measuring High-LET Particles Dose

Дымова, М. А.; Dmitrieva, Maria; Kuligina, Elena V.; Richter, Vladimír; Савинов, С. С.; Shchudlo, Ivan; Sycheva, T. V.; Taskaeva, Iuliia; Taskaev, Sergey

doi:10.1667/rade-21-00015.1

Cited by 7 publications

(2 citation statements)

References 19 publications

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“…Based on the irradiation settings and previously experimentally studied spatial distribution of the beam components [53], the irradiation fluences were calculated by the Monte Carlo method using an NMC code developed at the Nuclear Safety Institute of the Russian Academy of Sciences (IBRAE RAS) [54]. The characteristics of the beam, its contamination with fast neutrons and photons, and the neutron spectra were similar to those described previously [51,53,55,56]. One milliampere-hour resulted in the following fluences: thermal neutrons-2.608 × 10 12 /cm 2 , epithermal neutrons-7.696 × 10 10 /cm 2 , fast neutrons-6.118 × 10 10 /cm 2 , and photons-7.201 × 10 11 /cm 2 , with the absorbed doses as follows: fast neutrons-0.314 Gy, photons-2.997 Gy.…”

Section: Irradiation Experimentsmentioning

confidence: 99%

Polymer-Stabilized Elemental Boron Nanoparticles for Boron Neutron Capture Therapy: Initial Irradiation Experiments

et al. 2022

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Sufficient boron-10 isotope (10B) accumulation by tumor cells is one of the main requirements for successful boron neutron capture therapy (BNCT). The inability of the clinically registered 10B-containing borophenylalanine (BPA) to maintain a high boron tumor concentration during neutron irradiation after a single injection has been partially solved by its continuous infusion; however, its lack of persistence has driven the development of new compounds that overcome the imperfections of BPA. We propose using elemental boron nanoparticles (eBNPs) synthesized by cascade ultrasonic dispersion and destruction of elemental boron microparticles and stabilized with hydroxyethylcellulose (HEC) as a core component of a novel boron drug for BNCT. These HEC particles are stable in aqueous media and show no apparent influence on U251, U87, and T98G human glioma cell proliferation without neutron beam irradiation. In BNCT experiments, cells incubated with eBNPs or BPA at an equivalent concentration of 40 µg 10B/mL for 24 h or control cells without boron were irradiated at an accelerator-based neutron source with a total fluence of thermal and epithermal neutrons of 2.685, 5.370, or 8.055 × 1012/cm2. The eBNPs significantly reduced colony-forming capacity in all studied cells during BNCT compared to BPA, verified by cell-survival curves fit to the linear-quadratic model and calculated radiobiological parameters, though the effect of both compounds differed depending on the cell line. The results of our study warrant further tumor targeting-oriented modifications of synthesized nanoparticles and subsequent in vivo BNCT experiments.

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Section: Irradiation Experimentsmentioning

confidence: 99%

Polymer-Stabilized Elemental Boron Nanoparticles for Boron Neutron Capture Therapy: Initial Irradiation Experiments

et al. 2022

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“…Linear Energy Transfer (LET) is the amount of energy a particle delivers along this penetrating path to the material it travels through [24]. The value of LET determines how the particles interact with cells.…”

Section: Space Radiationmentioning

confidence: 99%

Extraterrestrial Gynecology: Could Spaceflight Increase the Risk of Developing Cancer in Female Astronauts? An Updated Review

Drago-Ferrante

Fiore

Karouia

et al. 2022

IJMS

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Outer space is an extremely hostile environment for human life, with ionizing radiation from galactic cosmic rays and microgravity posing the most significant hazards to the health of astronauts. Spaceflight has also been shown to have an impact on established cancer hallmarks, possibly increasing carcinogenic risk. Terrestrially, women have a higher incidence of radiation-induced cancers, largely driven by lung, thyroid, breast, and ovarian cancers, and therefore, historically, they have been permitted to spend significantly less time in space than men. In the present review, we focus on the effects of microgravity and radiation on the female reproductive system, particularly gynecological cancer. The aim is to provide a summary of the research that has been carried out related to the risk of gynecological cancer, highlighting what further studies are needed to pave the way for safer exploration class missions, as well as postflight screening and management of women astronauts following long-duration spaceflight.

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Measuring the Phase Portrait of an Ion Beam in a Tandem Accelerator with Vacuum Insulation

et al. 2022

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Method of Measuring High-LET Particles Dose

Cited by 7 publications

References 19 publications

Polymer-Stabilized Elemental Boron Nanoparticles for Boron Neutron Capture Therapy: Initial Irradiation Experiments

Polymer-Stabilized Elemental Boron Nanoparticles for Boron Neutron Capture Therapy: Initial Irradiation Experiments

Extraterrestrial Gynecology: Could Spaceflight Increase the Risk of Developing Cancer in Female Astronauts? An Updated Review

Measuring the Phase Portrait of an Ion Beam in a Tandem Accelerator with Vacuum Insulation

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