Method of immobilization of carboxymethyl-dextran affects resistance to tissue and cell colonization

End-grafted Sugar Chains as Aqueous Lubricant Additives: Synthesis and Macrotribological Tests of Poly(l-lysine)-graft-Dextran (PLL-g-dex) Copolymers

“…Second, since the dextran is neutral, it does not present problems due to electrostatic interactions when grafted onto a polycationic backbone (PLL). Finally, previous studies have shown the effectiveness of dextran coatings at preventing nonspecific protein adsorption [14][15][16][17][18][32][33][34][35][36][37][38][39][40], this being a property that often seems to be closely associated with good aqueous lubricating properties [5,6,41,42].…”

Two-dimensional patterning of thin coatings for the control of tissue outgrowth

“…Although there are numerous reports that describe two-dimensional patterning of substrates for the control of disaggregated cell attachment and migration, only few studies have attempted to control the growth of intact tissues in two dimensions [9]. The ability to provide spatial control over tissue growth may be particularly important for future tissue engineering procedures where cell sheets and tissues are assembled in vitro.…”

Chemical Immobilization of Biomolecules on Plasma‐Modified Substrates for Biomedical Applications

“…Carboxymethyldextrans (CMD)s can be conveniently used as model polysaccharide compounds and were attached onto plasma-deposited aminated Teflon (FEP) surfaces obtained both from the deposition of n-heptylamine displaying surface amino groups and by using surface aldehyde groups plasma deposited from acetaldehyde [32]. CMD with different molecular weights have been immobilized directly on coatings plasma deposited from n-heptylamine or through a polyamine spacer arm via a water-based coupling procedure using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and N-hydroxysuccinimide (NHS) as coupling reagents.…”