Method for producing coded micro-carrier and test method by using a novel type biochip

Chang, Rong Seng; Lee, D.Y.; Chen, W.Y.; Huang, Rong; Huang, Hau-Ming; Hsu, Jin–Cherng; Lin, Po-Chih

doi:10.1016/j.jbiotec.2003.10.019

Cited by 1 publication

(2 citation statements)

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“…Early theorization of developmental biochip systems [1,2] can be traced back to micro-array biochip and coded micro-carrier systems (for example also see our 2004 article [3] about coded micro-carrier biochips). An increasing number of recent publications and empirical studies have reassessed the positive contributions that code micro-carrier systems can make to biotechnology.…”

Section: Introductionmentioning

confidence: 99%

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Design and Control of a Ferromagnetic Coded Micro-Carrier Biochip Sensor for Multiplex Detection of Antibodies

Chang

Tsai

2011

Sensors

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This paper describes a method for producing a novel type of ferromagnetic coded micro-carrier. The ferromagnetic coded micro-carriers are about 200 μm in length, 200 μm in width and 50 μm in thickness, and contain eight code elements with two distinguishable codes (hollow and solid), allowing for 28 unique codes. The code shapes include rectangle, circle, etc. Differently shaped coded micro-carriers could carry different antigens for detection of its complementary antibody. These many shapes of coded micro-carriers would be used simultaneously allowing us to make multiple detections for different antibodies at the same time. A molding process is applied for fabrication of the ferromagnetically coded micro-carriers where Fe material (Fe powder mixed with binder) is shaped in many tiny molds to produce the coded shapes used for identification of the bio-molecules. Magnetic force is used to control the movement and location of the ferromagnetic coded micro-carriers to prevent the loss during the hybridization process. The results of image process and analysis system testing are satisfactory. The results of our micro-carrier detection system for two sets of R and B color analysis are proportional to those obtained from ELISA antibody detection.

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Section: Introductionmentioning

confidence: 99%

“…Early attempts [3] at exploring this issue have proved disappointing. In previous methods, the coded micro-carrier container was made by glass tube in which the bottom part was cut out and recovered by a hollowed mesh net to preserve the micro-carriers during the hybridized process.…”

Section: Introductionmentioning

confidence: 99%

Design and Control of a Ferromagnetic Coded Micro-Carrier Biochip Sensor for Multiplex Detection of Antibodies

Chang

Tsai

2011

Sensors

View full text Add to dashboard Cite

show abstract

Method for producing coded micro-carrier and test method by using a novel type biochip

Cited by 1 publication

References 8 publications

Design and Control of a Ferromagnetic Coded Micro-Carrier Biochip Sensor for Multiplex Detection of Antibodies

Design and Control of a Ferromagnetic Coded Micro-Carrier Biochip Sensor for Multiplex Detection of Antibodies

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