Method for Modeling Residual Variance in Biomedical Signals Applied to Transcranial Doppler Ultrasonography Waveforms

Abstract

Transcranial Doppler (TCD) ultrasonography measures pulsatile cerebral blood flow velocity in the arteries and veins of the head and neck. The velocity pulse waveform morphology has been shown to have physiological and diagnos-* Corresponding AuthorThe signal to noise ratio 90% range was [1.7, 18.2] dB. The estimated probability density functions were best characterized by a generalized normal distribution whose beta parameter was smaller than 2 in 93% of scans. The identified frequency structure showed the dynamics were low-pass in nature.Analysis of the TCD residuals is useful in the assessment of the signal quality.Moreover, our identified models can also be used to generate synthetic TCD signal that enables future realistic simulation studies.