Method for automatization of the alignment of a laboratory based x-ray phase contrast edge illumination system

Millard, T. P.; Endrizzi, Marco; Ignatyev, Konstantin; Hagen, Charlotte K.; Munro, Peter; Speller, RD; Olivo, Alessandro

doi:10.1063/1.4816827

Cited by 40 publications

(39 citation statements)

References 25 publications

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“…For a detailed explanation of the method's working principle, the reader is referred to previous publications. 10,15,17 The method was adjusted for tomographic imaging by inserting a rotation axis parallel to the masks' apertures (orthogonal to the direction of phase sensitivity). If, at each rotation angle, two projections are acquired at opposing edge illumination configurations [Figs.…”

Section: Methodsmentioning

confidence: 99%

“…[14][15][16][17][18] While previously tomographic images acquired with a monochromatic synchrotron source were shown, 8 in this paper, the first tomographic images obtained from an EI XPCi system implemented with a commercial laboratory xray tube are presented. The obtained results demonstrate the superiority of phase over attenuation based imaging, as well as the feasibility of imaging at doses well within the limits of what is considered acceptable for in vivo, e.g., small animal imaging applications.…”

Section: Introductionmentioning

confidence: 99%

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Low-dose phase contrast tomography with conventional x-ray sources

et al. 2014

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Purpose:The edge illumination (EI) x-ray phase contrast imaging (XPCi) method has been recently further developed to perform tomographic and, thus, volumetric imaging. In this paper, the first tomographic EI XPCi images acquired with a conventional x-ray source at dose levels below that used for preclinical small animal imaging are presented. Methods: Two test objects, a biological sample and a custom-built phantom, were imaged with a laboratory-based EI XPCi setup in tomography mode. Tomographic maps that show the phase shift and attenuating properties of the object were reconstructed, and analyzed in terms of signal-tonoise ratio and quantitative accuracy. Dose measurements using thermoluminescence devices were performed. Results:The obtained images demonstrate that phase based imaging methods can provide superior results compared to attenuation based modalities for weakly attenuating samples also in 3D. Moreover, and, most importantly, they demonstrate the feasibility of low-dose imaging. In addition, the experimental results can be considered quantitative within the constraints imposed by polychromaticity. Conclusions:The results, together with the method's dose efficiency and compatibility with conventional x-ray sources, indicate that tomographic EI XPCi can become an important tool for the routine imaging of biomedical samples.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Low-dose phase contrast tomography with conventional x-ray sources

et al. 2014

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“…It has been shown to provide high resolution, quantitative phase, and dark field images [21][22][23]. Low spatial and temporal coherence is extremely well tolerated by the technique, which is also stable against thermal and mechanical stresses [24][25][26][27]. The main concept behind the EI approach is that by strongly shaping the X-ray beam in one direction and inserting a sharp absorbing element before detection, small angular deviations in the direction of propagation of the X-rays are translated into intensity modulations at the detector.…”

Section: Introductionmentioning

confidence: 99%

Single-Shot X-ray Phase Retrieval through Hierarchical Data Analysis and a Multi-Aperture Analyser

2018

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Abstract:A multi-aperture analyser set-up was recently developed for X-ray phase contrast imaging and tomography, simultaneously attaining a high sensitivity and wide dynamic range. We present a single-shot image retrieval algorithm in which differential phase and dark-field images are extracted from a single intensity projection. Scanning of the object is required to build a two-dimensional image, because only one pre-sample aperture is used in the experiment reported here. A pure-phase object approximation and a hierarchical approach to the data analysis are used in order to overcome numerical instabilities. The single-shot capability reduces the exposure times by a factor of five with respect to the standard implementation and significantly simplifies the acquisition procedure by only requiring sample scanning during data collection.

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“…Several approaches have been proposed for XPCI by using synchrotron radiation, microfocal and extended labortory sources [2]. We focus here on edge illumination [3] in view of its properties of high resolution, sensitivity, robustness and achromaticity [4][5][6]. The latter is of particular interest for the study reported here, where we used the direct beam from a bending magnet, aiming at making use of a spectral distribution as broad as possible.…”

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confidence: 99%