Method development for determining the antibacterial linezolid in human serum by micellar electrokinetic capillary chromatography

Kitahashi, Toshihiro; Furuta, Itaru

doi:10.1016/s0731-7085(02)00475-2

Cited by 14 publications

(15 citation statements)

References 13 publications

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“…Several analytical assays concerning the measurement of linezolid in plasma by HPLC used UV detection [2,3,[10][11][12][13][14][15][16]. Some of them described a protein precipitation for sample clean-up [13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Determination of linezolid in plasma and bronchoalveolar lavage by high-performance liquid chromatography with ultraviolet detection using a fully automated extraction method

Toutain

Boselli

Djabarouti

et al. 2004

Journal of Chromatography B

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Section: Discussionmentioning

confidence: 99%

Determination of linezolid in plasma and bronchoalveolar lavage by high-performance liquid chromatography with ultraviolet detection using a fully automated extraction method

Toutain

Boselli

Djabarouti

et al. 2004

Journal of Chromatography B

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“…However, over the past several years, a number of CE-based pharmacokinetic applications have been developed for the measurement of ketoprofen, arotionolol, zidovudine (AZT), nevirapine, and ritonavir in human serum [122][123][124]. Similarly, applications for the study of urine samples have been developed for a variety of drugs such as oxprenolol, codeine, and triamterene using CZE and MEKC [125][126][127]. Although useful, as indicated elsewhere in the review, CE can lack sensitivity due to the small sample volume injected.…”

Section: Pharmacokinetic Studiesmentioning

confidence: 99%

Capillary electrophoresis and the clinical laboratory

et al. 2006

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Over the past 15 years, CE as an analytical tool has shown great promise in replacing many conventional clinical laboratory methods, such as electrophoresis and HPLC. CE's appeal was that it was fast, used very small amounts of sample and reagents, was extremely versatile, and was able to separate large and small analytes, whether neutral or charged. Because of this versatility, numerous methods have been developed for analytes that are of clinical interest. Other than molecular diagnostic and forensic laboratories CE has not been able to make a major impact in the United States. In contrast, in Europe and Japan an increasing number of clinical laboratories are using CE. Now that automated multicapillary instruments are commercially available along with cost-effective test kits, CE may yet be accepted as an instrument that will be routinely used in the clinical laboratories. This review will focus on areas where CE has the potential to have the greatest impact on the clinical laboratory. These include analyses of proteins found in serum and urine, hemoglobin (A1c and variants), carbohydrate-deficient transferrin, forensic and therapeutic drug screening, and molecular diagnostics.

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“…HPLC and LC-MS/ MS methods have been reported for determining linezolid concentration in blood and urine. Kitahashi et al [106] have developed and validated a method for determining linezolid concentration in human serum by MEKC. In this method, serum was deproteinized with acetonitrile and etofylline was used as an internal standard.…”

Section: Linezolidmentioning

confidence: 99%

Recent progress in pharmacokinetic applications of capillary electrophoresis

Lin

Chen

2003

Electrophoresis

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This review is a continuation of the previous reviews (Electrophoresis 1999, 20, 3259-3268; Electrophoresis 2001, 22, 4244-4248) to update the recent publications from 2001 to 2003 on pharmacokinetic studies using capillary electrophoresis (CE). During this period of time, CE remains as a unique analytical method for some studies, which would otherwise be limited by many factors, such as the sample volume, detection sensitivity, or separation power. It is particularly noticeable that the separation of chiral drugs in biological sample and the use of solid-phase extraction (SPE) as a simple and convenient means of sample preparation appear to become popular for CE-based assays. The use of CE for assessing complete pharmacokinetic information, however, did not show a significant growth during this period of time. In order to provide a broad range of view on how biological samples are analyzed by CE, this review will cover publications during the past two years on the use of CE for the analysis of drugs in biological fluids for general pharmacokinetic applications including drug monitoring and bioavailability studies.

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Method development for determining the antibacterial linezolid in human serum by micellar electrokinetic capillary chromatography

Cited by 14 publications

References 13 publications

Determination of linezolid in plasma and bronchoalveolar lavage by high-performance liquid chromatography with ultraviolet detection using a fully automated extraction method

Determination of linezolid in plasma and bronchoalveolar lavage by high-performance liquid chromatography with ultraviolet detection using a fully automated extraction method

Capillary electrophoresis and the clinical laboratory

Recent progress in pharmacokinetic applications of capillary electrophoresis

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