Methionine Synthase Reductase-A66G and -C524T Single Nucleotide Polymorphisms and Prostate Cancer: A Case-Control Trial

Basir, Atefeh

doi:10.31557/apjcp.2019.20.5.1445

Cited by 10 publications

(10 citation statements)

References 49 publications

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“…Our knowledge on the association of cancer and MTRR rs1532268 polymorphism is very limited. It has been reported that MTRR rs1532268 polymorphism was associated with increased risk of prostate cancer [28], while other studies did not reveal any obviously significant differences of MTRR rs1532268 polymorphisms among other cancers. Our finding indicated that patients with MTRR rs1532268 CT/TT genotypes played harmful role on GC prognosis.…”

Section: Discussionmentioning

confidence: 79%

Genetic polymorphisms in folate-metabolizing genes associated with gastric cancer prognosis in northwest China subjects

et al. 2020

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Influence of folate metabolism has long been studied in cancer and copies evidences have suggested that the key genes involved were correlated with GC risk and prognosis. However, their genetically association and contribution for GC prognosis are still elusive. To evaluate the effect of folate metabolism related genes polymorphisms on the prognosis of gastric cancer (GC), the genotype of seven single nucleotide polymorphisms (SNPs) of three genes were selected and genotyped in a cohort of 664 GC patients, including genes of Methylenetetrahydrofolate reductase (MTHFR), Methionine synthase reductase (MTRR), and Methionine synthase (MTR). Kaplan-Meier Curve, long-rank tests and multivariate Cox proportional hazard model were used for prognosis analysis. The results demonstrated that TT or CT/TT genotypes of SNP rs1532268 in MTRR gene coding region are significantly associated with a poorer overall survival (OS) when compared with CC genotype (HR=2.340, 95% CI: 1.240-4.414, p=0.009; or HR=1.502, 95% CI: 1.083-2.085, p=0.015, respectively). Furthermore, comparing to that of the CC genotype, the detrimental effect of rs1532268 TT genotype was also evident in the special subgroups of GC patients, especially in patients with BMI<24 and H. pylori infection. Moreover, significant association between increased relapse and TT genotype of rs1532268 was also observed in patients who are females, BMI<24 and without chemotherapy. In addition, the joint analysis demonstrated that integration of rs1532268 genotypes and BMI, H. pylori infection status, clinical stage and tumor site may significantly improve the predictive abilities for predicting OS of GC patients. In conclusion, it suggested that the MTRR rs1532268 polymorphism is significantly associated with clinical outcomes of GC patients, especially in those with lower BMI (BMI<24) or positive H. pylori infection status, which warrants further validation. And the polymorphism of MTRR rs1532268 may be a potential prognostic factor for GC patients.

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Section: Discussionmentioning

confidence: 79%

Genetic polymorphisms in folate-metabolizing genes associated with gastric cancer prognosis in northwest China subjects

et al. 2020

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“…For MTRR A66G meta-analysis, total eight studies with 3,631 cases and 5,076 controls [39, 40, 45, 48, 49, 50, 62, present study]. Out of which, three were Asian, three were Caucasian and two were of mixed ethnicities.…”

Section: Resultsmentioning

confidence: 99%

“…A number of studies were conducted to check the association of MTHFR C677T gene polymorphism with the prostate cancer [35][36][37][38][39][40][41][42][43][44][45][46][47]. Very few studies were published, which evaluated MTRR A66G polymorphism as risk for prostate cancer [39,40,[48][49][50]. The results of these studies were contradictory for both the selected (MTHFR C677T and MTRR A66G gene) polymorphisms.…”

Section: Introductionmentioning

confidence: 99%

Folate (MTHFRC677T andMTRRA66G) gene polymorphisms and risk of prostate cancer: a case-control study with an updated meta-analysis

Yadav

Kumar

Dwivedi

et al. 2021

Preprint

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IntroductionMethylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are the key enzymes of the folate pathway, which involved in the DNA methylation. DNA methylation may affect the stability and integrity of DNA, that supposed to play a pivotal role in carcinogenesis. So, we aimed to investigate the association of MTHFR C677T and MTRR A66G gene polymorphisms with susceptibility to prostate cancer in North Indian population. We also performed meta-analyses of published literatures on these polymorphisms to evaluate their association with prostate cancer.MethodsWe genotyped MTHFR C677T and MTRR A66G gene polymorphisms in 147 prostate cancer cases and 147 healthy controls using PCR-RFLP methods. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated for risk estimation. For meta-analysis different databases were searched and all statistical analysis were performed using Open Meta-Analyst software.ResultsThe present case control study revealed that the T allele (OR= 1.67; 95% CI: 0.99-2.84, p= 0.05), CT genotype (OR= 1.92; 95% CI: 1.06-3.48, p= 0.02), and dominant (TT+CT) model (OR= 1.85; 95% CI: 1.05-3.30, p= 0.03) of MTHFR C677T gene polymorphism and G allele (OR= 1.92; 95% CI: 1.35-2.73, p= 0.0002) of MTRR A66G gene polymorphism were significantly associated with prostate cancer susceptibility. Meta-analyses of MTHFR C677T and MTRR A66G gene polymorphisms showed no significant association between these polymorphisms and prostate cancer risk in overall or in subgroup meta-analysis stratified by ethnicity.ConclusionMTHFR C677T and MTRR A66G gene polymorphisms seem to play a significant role in prostate cancer susceptibility in North Indian population, while results of meta-analysis revealed no association between MTHFR C677T and MTRR A66G gene polymorphisms and prostate cancer susceptibility.

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“…Other enzymes of the homocysteine metabolic pathway are Methylenetetrahydrofolate Reductase (MTHFR) and Thymidylate Synthase (TS). MTRR is involved in reduction of MTR-cob (II) alamin to MTR-cob (I) alamin, and transform 5-methyltetrahydrofolate to tetrahydrofolate [ 94 , 95 ]. The MTRR 66A > G (rs1801394) polymorphism changes an isoleucine into a methionine (Ile22Met) leading to the reduced enzyme activity [ 96 ].…”

Section: Amino Acid Metabolismmentioning

confidence: 99%

Genetic and molecular biology of autism spectrum disorder among Middle East population: a review

et al. 2021

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Background Autism spectrum disorder (ASD) is a neurodevelopmental disease, characterized by impaired social communication, executive dysfunction, and abnormal perceptual processing. It is more frequent among males. All of these clinical manifestations are associated with atypical neural development. Various genetic and environmental risk factors are involved in the etiology of autism. Genetic assessment is essential for the early detection and intervention which can improve social communications and reduce abnormal behaviors. Although, there is a noticeable ASD incidence in Middle East countries, there is still a lack of knowledge about the genetic and molecular biology of ASD among this population to introduce efficient diagnostic and prognostic methods. Main body In the present review, we have summarized all of the genes which have been associated with ASD progression among Middle East population. We have also categorized the reported genes based on their cell and molecular functions. Conclusions This review clarifies the genetic and molecular biology of ASD among Middle East population and paves the way of introducing an efficient population based panel of genetic markers for the early detection and management of ASD in Middle East countries.

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Methionine Synthase Reductase-A66G and -C524T Single Nucleotide Polymorphisms and Prostate Cancer: A Case-Control Trial

Cited by 10 publications

References 49 publications

Genetic polymorphisms in folate-metabolizing genes associated with gastric cancer prognosis in northwest China subjects

Genetic polymorphisms in folate-metabolizing genes associated with gastric cancer prognosis in northwest China subjects

Folate (MTHFRC677T andMTRRA66G) gene polymorphisms and risk of prostate cancer: a case-control study with an updated meta-analysis

Genetic and molecular biology of autism spectrum disorder among Middle East population: a review

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