Methionine restriction - Association with redox homeostasis and implications on aging and diseases

Zhang, Yuyu; Jelleschitz, Julia; Grune, Tilman; Chen, Weixuan; Zhao, Yihang; Jia, Mengzhen; Wang, Yajie; Höhn, Annika; Liu, Zhigang

doi:10.1016/j.redox.2022.102464

Cited by 14 publications

(9 citation statements)

References 262 publications

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“…Additionally, methionine supplementation during pregnancy reverses the negative effect of maternal malnutrition on the developing kidney, contributing to nephrogenesis and later kidney health in adulthood; this was mediated through the mTORC1 pathway in a calorie-restricted-diet mouse model [ 44 ]. Despite consumption of methionine being essential to sustain life, basic experimental evidence has shown that methionine restriction provides benefits in impairment of glucose disorder, increasing insulin sensitivity, amelioration of oxidative stress and inflammation, and extension of healthy lifespan [ 45 , 46 ]. Subsequent studies have also pointed out that the effects of limiting methionine in the diet of rats depend on stimulation of FGF21, protein phosphatase 2A (PP2A), and autophagy-related mTOR and UNC-51-like kinase 1 (ULK1) [ 11 ] ( Figure 3 ).…”

Section: Methionine and Its Metabolite Homocysteinementioning

confidence: 99%

Metabolic Homeostasis of Amino Acids and Diabetic Kidney Disease

Luo-kun

Zhang

et al. 2022

Nutrients

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Diabetic kidney disease (DKD) occurs in 25–40% of patients with diabetes. Individuals with DKD are at a significant risk of progression to end-stage kidney disease morbidity and mortality. At present, although renal function-decline can be retarded by intensive glucose lowering and strict blood pressure control, these current treatments have shown no beneficial impact on preventing progression to kidney failure. Recently, in addition to control of blood sugar and pressure, a dietary approach has been recommended for management of DKD. Amino acids (AAs) are both biomarkers and causal factors of DKD progression. AA homeostasis contributes to renal hemodynamic response and glomerular hyperfiltration alteration in diabetic patients. This review discusses the links between progressive kidney dysfunction and the metabolic homeostasis of histidine, tryptophan, methionine, glutamine, tyrosine, and branched-chain AAs. In addition, we emphasize the regulation effects of special metabolites on DKD progression, with a focus on causality and potential mechanisms. This paper may offer an optimized protein diet strategy with concomitant management of AA homeostasis to reduce the risks of DKD in a setting of hyperglycemia.

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Section: Methionine and Its Metabolite Homocysteinementioning

confidence: 99%

Metabolic Homeostasis of Amino Acids and Diabetic Kidney Disease

Luo-kun

Zhang

et al. 2022

Nutrients

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“…As a corollary, we might have underestimated the methionine intake in our studies. According to some researchers, Western diets contain methionine at levels many times higher than dietary requirements [ 63 ]. Our data suggest that the methionine intake in our sample is far above common dietary recommendations, and thus, it could have contributed to the increased DAL and, subsequently, increased cancer risks.…”

Section: Discussionmentioning

confidence: 99%

Dietary Acid Load and Cancer Risk: A Review of the Uruguayan Experience

Ronco

Storz

2023

Nutrients

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Dietary acid load (DAL) is recognized as a risk factor for several chronic disorders, including obesity, diabetes, and osteoporosis. Recent evidence suggests that an elevated DAL, as measured by the validated potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores, could also increase the risk for several cancers. This narrative review summarizes the potential role of DAL in Uruguayan cancer patients and outlines the potentially involved pathophysiological pathways that mediate the role of DAL in both cancer development and growth. Although Uruguay is a developing country, its average diet is a heavily meat-based Western one, translating into a supraphysiological acid burden from diet. In recent years, we have published epidemiologic evidence based on ten case-control studies involving 3736 cancer cases and 9534 hospital-based controls. Odds ratios and 95% confidence intervals were estimated for each interest variable to analyze the association between the exposure levels of DAL scores and cancer, calculated by unconditional logistic regression. In a majority of the cases, the highest DAL scores tended to double the cancer risk as compared to the lowest category. We also found high risks for methionine intake, an acidifying amino acid found in higher concentrations in animal-based foods, which may increase cancer risks at least by a joint action based on the pH and the proliferation enhancing properties of the amino acid itself.

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“…For example, specific strains of bacteria, such as Bifidobacterium longum CCFM752, Lactobacillus plantarum CCFM10, and L. plantarum CCFM1149 can induce the production of crucial antioxidant defense enzymes such as glutathione peroxidase ( Guo et al, 2022 ), catalase ( Chen et al, 2021 ), and superoxide dismutase (SOD) ( Wang et al, 2020 ). The normal gut microbiota can enhance the body’s ability to scavenge ROS and maintain redox homeostasis by promoting the synthesis of these enzymes ( Yardeni et al, 2019 ; Zhang Y. et al, 2022 ). A balanced gut microbiota is essential for maintaining a healthy gut environment.…”

Section: The Crosstalk Between Gut Microbiota and Oxidative Stressmentioning

confidence: 99%

The role of gut microbiota in intestinal disease: from an oxidative stress perspective

Sun,

Wang,

et al. 2024

Front. Microbiol.

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Recent studies have indicated that gut microbiota-mediated oxidative stress is significantly associated with intestinal diseases such as colorectal cancer, ulcerative colitis, and Crohn’s disease. The level of reactive oxygen species (ROS) has been reported to increase when the gut microbiota is dysregulated, especially when several gut bacterial metabolites are present. Although healthy gut microbiota plays a vital role in defending against excessive oxidative stress, intestinal disease is significantly influenced by excessive ROS, and this process is controlled by gut microbiota-mediated immunological responses, DNA damage, and intestinal inflammation. In this review, we discuss the relationship between gut microbiota and intestinal disease from an oxidative stress perspective. In addition, we also provide a summary of the most recent therapeutic approaches for preventing or treating intestinal diseases by modifying gut microbiota.

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Methionine restriction - Association with redox homeostasis and implications on aging and diseases

Cited by 14 publications

References 262 publications

Metabolic Homeostasis of Amino Acids and Diabetic Kidney Disease

Metabolic Homeostasis of Amino Acids and Diabetic Kidney Disease

Dietary Acid Load and Cancer Risk: A Review of the Uruguayan Experience

The role of gut microbiota in intestinal disease: from an oxidative stress perspective

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