Methionine nutrition in swine and related monogastric animals: Beyond protein biosynthesis

Yang, Zhongyue; Htoo, J. K.; Liao, Shengfa F

doi:10.1016/j.anifeedsci.2020.114608

Cited by 19 publications

(18 citation statements)

References 134 publications

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“…A sufficient supply of sulfur-containing AA, Met and Cys, from diet or from tissue protein breakdown, is necessary for the synthesis of a myriad of proteins and peptides involved in the normal functions of the immune systems of pigs [ 72 ]. Methionine serves as a methyl donor for several important processes, such as DNA methylation and polyamine synthesis [ 73 ], which are important for enhancing immune cell proliferation during an immune challenge.…”

Section: Amino Acid Effects On Gut Immunological Functionsmentioning

confidence: 99%

“…The antioxidative ability of Met can protect many proteins from oxidative damage [ 85 ]. Dietary Met for nursery pigs enhanced the duodenum morphology in association with reduced oxidative stress and improved GSH production in mucosa cells [ 36 , 72 ]. Some complex, but coordinated, responses of antioxidant systems were observed in different tissues when growing pigs faced an insufficient dietary Met supply [ 86 ].…”

Section: The Anti-oxidative Functions Of Amino Acidsmentioning

confidence: 99%

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Invited Review: Maintain or Improve Piglet Gut Health around Weanling: The Fundamental Effects of Dietary Amino Acids

Liao

2021

Animals

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Gut health has significant implications for swine nutrient utilization and overall health. The basic gut morphology and its luminal microbiota play determinant roles for maintaining gut health and functions. Amino acids (AA), a group of essential nutrients for pigs, are not only obligatory for maintaining gut mucosal mass and integrity, but also for supporting the growth of luminal microbiota. This review summarized the up-to-date knowledge concerning the effects of dietary AA supplementation on the gut health of weanling piglets. For instance, threonine, arginine, glutamine, methionine and cysteine are beneficial to gut mucosal immunity and barrier function. Glutamine, arginine, threonine, methionine and cysteine can also assist with relieving the post-weaning stress of young piglets by improving gut immunological functions, antioxidant capacity, and/or anti-inflammatory ability. Glutamine, glutamate, glycine and cysteine can assist to reconstruct the gut structure after its damage and reverse its dysfunction. Furthermore, methionine, lysine, threonine, and glutamate play key roles in affecting bacteria growth in the lumen. Overall, the previous studies with different AA showed both similar and different effects on the gut health, but how to take advantages of all these effects for field application is not clear. It is uncertain whether these AA effects are synergetic or antagonistic. The interactions between the effects of non-nutrient feed additives and the fundamental effects of AA warrant further investigation. Considering the global push to minimize the antibiotics and ZnO usage in swine production, a primary effort at present may be made to explore the specific effects of individual AA, and then the concert effects of multiple AA, on the profile and functions of gut microbiota in young pigs.

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Section: Amino Acid Effects On Gut Immunological Functionsmentioning

confidence: 99%

Section: The Anti-oxidative Functions Of Amino Acidsmentioning

confidence: 99%

Invited Review: Maintain or Improve Piglet Gut Health around Weanling: The Fundamental Effects of Dietary Amino Acids

Liao

2021

Animals

Self Cite

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Section: Introductionmentioning

confidence: 99%

“…Known as 2-amino-4-methylthio butanoic acid in chemistry, methionine (Met) is usually the second or third limiting amino acid (AA) in typical swine diets [1]. Commercial product of crystalline DL-Met that consists of 50% D-Met and 50% L-Met is commonly added to the swine diets that are low in Met content [1,2]. In addition to functioning as a building block for body protein biosynthesis [3,4], Met has several other biological functions that include (1) protein translation initiation, (2) methyl donation, (3) sulfur source, (4) endogenous antioxidant, (5) precursor of bioactive compounds such as taurine, glutathione, choline, and betaine, and (6) an intermediary in the synthesis of cysteine (Cys) or cystine [1,5].…”

Section: Introductionmentioning

confidence: 99%

Changes in growth performance, plasma metabolite concentrations, and myogenic gene expression in growing pigs fed a methionine-restricted diet

Yang

Hasan

Humphrey

et al. 2021

Front Biosci (Landmark Ed)

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Introduction 3. Materials and methods 3.1 Animal trial and growth performance evaluation 3.2 Sample collection for laboratory analyses 3.3 Analyses of plasma nutrient metabolites 3.4 Analysis of myogenic gene expression 3.5 Statistical analysis 4. Results and discussion 4.1 Growth performance 4.2 Plasma free amino acid profile 4.3 Plasma concentrations of nutrient metabolites 4.4 Myogenic gene expression 5. Conclusions 6. Author contributions 7. Ethics approval and consent to participate 8. Acknowledgment 9. Funding 10. Conflict of interest 11. References

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“…Sci. 2021, 11, 6384 2 of 10 Among essential amino acids, methionine (Met) has key importance in protein synthesis, methyl donation, and in antioxidant and immune defense processes in swine [5]. Free Met delivery may recover growth performance in pigs receiving a Met-deficient diet [6,7] due to nitrogen retention and muscle protein accretion by increasing protein biosynthesis [8] and decreasing protein degradation [9].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Absorption of Methionine Carried by Mineral Clays and Zeolites in Porcine Ex Vivo Permeability Models

et al. 2021

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Supplemental dietary amino acids (AAs) need to be provided in a form that prevents their degradation along the gastrointestinal tract to guarantee their high bioavailability and bioactivity. In this study, methionine (Met) protected via organo-clay intercalation (natural carriers) has been developed as a sustainable alternative to polymeric coating. Specifically, two different bentonite-zeolite-based mineral clays were tested, Adsorbene (ADS) and BioKi (BIO). Briefly, 1 g of the carrier (ADS or BIO) was contacted with 50 mL of an aqueous solution at a pH of 3.0, 5.8, and 8.9. Solid-liquid separation was conducted. The released Met in the liquid phase was analysed by Chemical Oxygen Demand, while residual Met in the solid phase was analysed by Fourier Transform Infra-Red (FT-IR) spectroscopy. The effect of Met-ADS complex on cell viability was tested on IPEC-J2 cells incubated 3 h with Met-ADS 2.5 mM. Jejunum segments obtained by entire male pigs (Swiss Large White, body weight 100 ± 5 kg) were used as ex vivo models to compare the absorption of 2.5 mM Met released by ADS with 2.5 mM free Met and its influence on epithelial integrity in perfusion Ussing chambers. The carriers released a very low amount of Met and Met-BIO interaction was stronger than Met-ADS. The maximum release of Met was at pH 3, with 3% and 6% of Met release from Met-BIO and Met-ADS, respectively. Cell viability experiments revealed that Met-ADS did not alter cell metabolic activity. No differences in Met absorption and intestinal epithelial integrity were observed ex vivo between free Met and Met-ADS. This study provided new insights into the release of Met from natural clays such as ADS and BIO, the safety of its use in the porcine intestine and the ability of ADS-released Met to absorb to the same extent as the free Met in porcine jejunum.

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Methionine nutrition in swine and related monogastric animals: Beyond protein biosynthesis

Cited by 19 publications

References 134 publications

Invited Review: Maintain or Improve Piglet Gut Health around Weanling: The Fundamental Effects of Dietary Amino Acids

Invited Review: Maintain or Improve Piglet Gut Health around Weanling: The Fundamental Effects of Dietary Amino Acids

Changes in growth performance, plasma metabolite concentrations, and myogenic gene expression in growing pigs fed a methionine-restricted diet

Evaluation of the Absorption of Methionine Carried by Mineral Clays and Zeolites in Porcine Ex Vivo Permeability Models

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