Methionine-enriched diet decreases hippocampal antioxidant defences and impairs spontaneous behaviour and long-term potentiation in rats

Viggiano, Alessandro; Viggiano, Emanuela; Monda, Marcellino; Ingrosso, Diego; Perna, Alessandra F.; Luca, B. De

doi:10.1016/j.brainres.2012.06.048

Cited by 21 publications

(14 citation statements)

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“…It seems likely that the alterations in cognitive functions observed in HHcy animals might be due to modified neural circuits as a consequence of impaired serotonergic neurotransmission. This impairment may be due to Hcy‐induced oxidative stress in brain as previously reported . Moreover, in a study by Gao et al , Hcy dependent decrease in the levels of catecholamines (dopamine and norepinephrine) and serotonin were observed.…”

Section: Discussionsupporting

confidence: 61%

Hydrogen sulfide attenuates homocysteine‐induced cognitive deficits and neurochemical alterations by improving endogenous hydrogen sulfide levels

2017

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Hyperomocysteinemia (HHcy) has been associated with mild cognitive impairment and dementia. Hydrogen sulfide (H S) has been suggested to be an endogenous modulator of neuronal functions. However, the effect and mechanisms involved in beneficial effect of H S has not been investigated in homocysteine (Hcy)-induced cognitive deficits. This study has been designed to evaluate the effect of exogenous H S on behavioral deficits and neurochemical alterations in HHcy animals. Hcy levels were significantly elevated in plasma, cortex, and hippocampus of Hcy administered animals. A progressive decline in memory functions and increased anxiolytic behavior was observed in HHcy animals. This was accompanied by decrease in endogenous H S levels along with decreased activity of cystathionase (CSE) and cystathionine β-synthase (CBS). However, a significant increase in CSE and CBS mRNAs was observed. In addition, the catecholamine and serotonin levels were reduced and the activity of monoamine oxidase A and B were increased in brain regions of HHcy animals. Haematoxylin and eosin staining revealed higher number of pyknotic cells in brain regions of HHcy animals. H S administration was found to lower elevated plasma and brain Hcy levels. The activities of CBS, CSE, and levels of H S were restored in HHcy animals administered H S. Exogenous H S also ameliorated behavioral deficits accompanied by significant increase in catecholamines. Histological analysis revealed normal cell morphology in Hcy-treated animals supplemented with H S. These results clearly demonstrate that the protective effect of H S on Hcy-induced cognitive deficits is mediated through increased catecholamine and H S levels thereby suggesting its beneficial role in preventing HHcy-induced neurodegeneration. © 2016 BioFactors, 43(3):434-450, 2017.

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Section: Discussionsupporting

confidence: 61%

Hydrogen sulfide attenuates homocysteine‐induced cognitive deficits and neurochemical alterations by improving endogenous hydrogen sulfide levels

2017

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“…Rats fed with a methionine enriched-diet presented increased levels of anxiety evaluated in an elevated plus maze test and increased superoxide dismutase (SOD) activity in the cerebral cortex when compared to controls [42]. Another study suggested that the highly palatable diet (enriched with sucrose) intake led to an obese phenotype, increased protein oxidation in frontal cortex and appeared to induce anxiety-like behavior in rats [5].…”

Section: Anxiety and Oxidative Stress In Animal Modelsmentioning

confidence: 99%

Oxidative Imbalance and Anxiety Disorders

Krolow

Arcego

Noschang

et al. 2014

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The oxidative imbalance appears to have an important role in anxiety development. Studies in both humans and animals have shown a strong correlation between anxiety and oxidative stress. In humans, for example, the increased malondialdehyde levels and discrepancies in antioxidant enzymes in erythrocytes have been observed. In animals, several studies also show that anxiety-like behavior is related to the oxidative imbalance. Moreover, anxiety-like behavior can be caused by pharmacological-induced oxidative stress. Studies using knockout or overexpression of antioxidant enzymes have shown a relationship between anxiety-like behavior and oxidative stress. Related factors of oxidative stress that could influence anxious behavior are revised, including impaired function of different mitochondrial proteins, inflammatory cytokines, and neurotrophic factors. It has been suggested that a therapy specifically focus in reducing reactive species production may have a beneficial effect in reducing anxiety. However, the neurobiological pathways underlying the effect of oxidative stress on anxiety symptoms are not fully comprehended. The challenge now is to identify the oxidative stress mechanisms likely to be involved in the induction of anxiety symptoms. Understanding these pathways could help to clarify the neurobiology of the anxiety disorder and provide tools for new discovery in therapies and preventive strategies.

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“…These studies have also reported mixed neurobehavioural responses [1,[12][13][14][15][16]. Methionine has been reported to cause locomotor retardation, memory impairment and anxiety [14,17], but in a few studies, no behavioural effects were seen [15,16]. Methionine metabolites like homocysteine have also been linked to reduction in learning and long-term potentiation [7,18,19], while SAMe has been associated with memory improvement [20].…”

Section: Introductionmentioning

confidence: 99%

Low-dose L-methionine-associated Changes in Behavioural Indices in Young Rats

Onaolapo¹,

Onaolapo²,

Blessing³

et al. 2016

ijnbs

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Objective: The study objectives were to investigate the effects of L-methionine (at low doses) on open-field novelty-induced behaviours, anxiety-related behaviours, working-memory and brain S-adenosyl-methionine (SAMe) levels in young rats. This was with a view to determine whether administration of low doses of L-methionine can significantly alter behavioural parameters, working-memory and brain SAMe levels, or not. Methodology: Wistar rats (40-45 g each) were given distilled water or L-methionine (5 and 10 mg/kg body weight) orally for 21 days. Behaviours were assessed after the first and last dose of L-methionine. Results: In the open field, significant increases in horizontal locomotion and rearing were seen after the first dose, while repeated administration led to their suppression. Suppression of grooming behaviour was observed at both times of assessment. Working-memory in the radial-arm maze was significantly reduced following repeated administration; while the elevated plus-maze test revealed anxiolytic responses following both acute and repeated administration. Patterns of changes in horizontal locomotion in the y-maze and radial-arm maze were similar to that of the open-field. There was no significant difference in brain levels of SAMe at end of study. Conclusion: The study demonstrated an association between low dose L-methionine administration and behavioural changes in young rats. It therefore brings to light, the behavioural changes that may occur due to addition of low doses of L-methionine to the diet.

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Methionine-enriched diet decreases hippocampal antioxidant defences and impairs spontaneous behaviour and long-term potentiation in rats

Cited by 21 publications

References 57 publications

Hydrogen sulfide attenuates homocysteine‐induced cognitive deficits and neurochemical alterations by improving endogenous hydrogen sulfide levels

Hydrogen sulfide attenuates homocysteine‐induced cognitive deficits and neurochemical alterations by improving endogenous hydrogen sulfide levels

Oxidative Imbalance and Anxiety Disorders

Low-dose L-methionine-associated Changes in Behavioural Indices in Young Rats

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