Methionine enkephalin-like, substance P-like, and β-endorphin-like immunoreactivity in human parotid saliva

Pikuła, Dorota; Harris, Edward F.; Desiderio, Dominic M.; Fridland, Genevieve; Lovelace, Jerry L.

doi:10.1016/0003-9969(92)90076-k

Cited by 34 publications

(14 citation statements)

References 31 publications

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“…Although saliva is mainly composed of water, it also consists of enzymes, ions, hormones and immune markers produced mostly by the salivary glands (Pedersen et al, 2002). Salivary cortisol is the commonly used biomarker of psychological stress (Hellhammer et al, 2009), and some components in saliva such as α-amylase (Nater et al, 2006), β-endorphin (Pikula et al, 1992) and Immunoglobulin A (IgA) (Moreira et al, 2011) have been shown to respond to biological stress.…”

Section: Introductionmentioning

confidence: 99%

Response to lipopolysaccharide in salivary components and the submandibular gland of pigs

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Response to lipopolysaccharide in salivary components and the submandibular gland of pigs

et al. 2014

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“…Therefore, saliva is considered to be a good material for evaluating the stress condition, and salivary biomarkers to evaluate stress have received much attention in humans [28]. Several salivary markers related to stress have been reported, including cortisol [10,13,27], -amylase [19,27], -endorphin [21], and chromogranin A [11]. Salivary Immunoglobulin A (IgA) has also been reported to be a potential stress marker in rats [8], humans [30] and dogs [12].…”

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confidence: 99%

Salivary IgA as a Useful Non-Invasive Marker for Restraint Stress in Pigs

et al. 2010

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ABSTRACT. In this study, we investigated the expression of immunoglobulin A (IgA) in porcine salivary gland and its relationship with restraint stress in pigs. IgA was expressed in plasma cells in pig salivary gland, as confirmed by immunohistochemical staining. IgA was also detected in pig saliva itself by ELISA, and salivary IgA levels were increased by a restraint stress. Moreover, there was a circadian rhythm of IgA over the course of a day. These results are the first evidence of IgA expression related to stress in the pig saliva and may make IgA useful as a non-invasive biological marker to evaluate acute stress condition in the pigs.KEY WORDS: IgA, non-invasive biomarker, restraint stress, saliva, salivary glands.

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“…OGF is an autocrine‐produced peptide in the ocular surface epithelium20 and OGF and OGFr have been detected by immunoreactivity in a variety of SCCHN and normal epithelium, both in vivo and in vitro. In addition, OGF has been detected in saliva 21, 22…”

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Defects in the opioid growth factor receptor in human squamous cell carcinoma of the head and neck

McLaughlin¹,

Stack²,

Levin³

et al. 2003

Cancer

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BACKGROUNDThe endogenous opioid peptide, [Met5]‐enkephalin, termed opioid growth factor (OGF), interacts with its receptor (OGFr) to play a role as a constitutively expressed inhibitory growth factor in the proliferation of epithelial cells. This study compared protein and gene expression of OGFr in surgical specimens of human squamous cell carcinoma of the head and neck (SCCHN) with normal epithelium.METHODSTissues from 64 patients with SCCHN and from 49 patients undergoing uvulapalatoplasty or tonsillectomy were utilized. Binding affinity and capacity were assessed by receptor binding assays and the levels of OGFr protein were determined by quantitative Western blot analysis. Immunohistochemistry assessed the presence and distribution of OGFr. Levels of OGFr mRNA were quantitated by Northern blot analysis. Protein and gene expressions of OGFr also were evaluated in the margins of SCCHN.RESULTSBinding analyses indicated nearly ninefold fewer OGFr binding sites in tumor tissue in comparison with normal samples. The OGFr protein levels were reduced fivefold in tumor tissues relative to normal epithelium. Values of OGFr mRNA were comparable in tumors and normal epithelium. Tumor margins had intermediate levels of protein and binding, but OGFr mRNA values were similar to those of normal specimens.CONCLUSIONSThese data demonstrate that OGFr is defective in SCCHN and that translation/posttranslation of OGFr protein, but not transcriptional levels of the OGFr gene, is involved. In addition, the attenuated levels of OGFr binding capacity may serve as a marker for SCCHN. These subnormal levels of OGFr may be responsible in part for tumor progression, diminishing the interaction of OGF with OGFr that aids in stabilizing cell replication by an inhibitory mechanism. Gene therapy to reinstate OGFr and/or function could provide a useful treatment for inhibiting tumor progression. Cancer 2003;97:1701–10. © 2003 American Cancer Society.DOI 10.1002/cncr.11237

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Methionine enkephalin-like, substance P-like, and β-endorphin-like immunoreactivity in human parotid saliva

Cited by 34 publications

References 31 publications

Response to lipopolysaccharide in salivary components and the submandibular gland of pigs

Response to lipopolysaccharide in salivary components and the submandibular gland of pigs

Salivary IgA as a Useful Non-Invasive Marker for Restraint Stress in Pigs

Defects in the opioid growth factor receptor in human squamous cell carcinoma of the head and neck

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