Methionine enkephalin activates autophagy and stimulates tumour cell immunogenicity in human cutaneous squamous cell carcinoma

Bai, Xueli; Cao, Xia; Qu, Na; Huang, Hai; Handley, Mike; Zhang, Shuling; Shan, Fengping

doi:10.1016/j.intimp.2021.107733

Cited by 7 publications

(3 citation statements)

References 57 publications

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“…Furthermore, 1 h treatment with 1 µM Met-enkephalin suppressed the proliferation of keratinocytes by 15-20% as demonstrated by 3 H-thymidine incorporation assay [130]. Considering the target spectrum of Met-enkephalin (Figure 2), one may speculate that this latter effect might have been due to the activation of ζ (OGF) receptor that was shown to suppress proliferation of several cell types, including epidermal keratinocytes [107,108,131]. Met-enkephalin, on the other hand, was also shown to promote outgrowth of murine keratinocytes from skin explants [132].…”

Section: Opioidergic Signaling and The Proliferation/differentiation ...mentioning

confidence: 95%

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Opioidergic Signaling—A Neglected, Yet Potentially Important Player in Atopic Dermatitis

Ádám

Arany

Tóth

et al. 2022

IJMS

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Atopic dermatitis (AD) is one of the most common skin diseases, the prevalence of which is especially high among children. Although our understanding about its pathogenesis has substantially grown in recent years, and hence, several novel therapeutic targets have been successfully exploited in the management of the disease, we still lack curative treatments for it. Thus, there is an unmet societal demand to identify further details of its pathogenesis to thereby pave the way for novel therapeutic approaches with favorable side effect profiles. It is commonly accepted that dysfunction of the complex cutaneous barrier plays a central role in the development of AD; therefore, the signaling pathways involved in the regulation of this quite complex process are likely to be involved in the pathogenesis of the disease and can provide novel, promising, yet unexplored therapeutic targets. Thus, in the current review, we aim to summarize the available potentially AD-relevant data regarding one such signaling pathway, namely cutaneous opioidergic signaling.

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Section: Opioidergic Signaling and The Proliferation/differentiation ...mentioning

confidence: 95%

“…did not increase the proliferation but almost completely abrogated the effect of Met-enkephalin (OGF) [108]. Last, but not least, Metenkephalin (OGF) also suppressed the proliferation of A431 cells (a human squamous cell-cancer-derived cell line) by activating OGF receptor [131].…”

Section: Opioidergic Signaling and The Proliferation/differentiation ...mentioning

confidence: 99%

Opioidergic Signaling—A Neglected, Yet Potentially Important Player in Atopic Dermatitis

Ádám

Arany

Tóth

et al. 2022

IJMS

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“…MET blocked the cell growth of cutaneous squamous cell carcinomas by inducing the G0/G1 cell cycle arrest and by promoting apoptotic mechanisms through the caspase 3/Bax/Bcl-2 signaling pathway [173]. MET, through the opioid growth factor receptor, blocked the proliferation of A431 cells by inducing apoptosis, promoting autophagy in cutaneous squamous cell carcinoma cells, and activating dendritic cells [174]. MET also decreased immunosuppression by reducing the number of myeloid-derived suppressor cells, controlling the polarization of tumor-associated macrophages from M2 to M1, and inhibiting the JAK2/STAT3 tumor-promotion/immunosuppression signaling pathway, which is involved in macrophage polarization and myeloid-derived suppressor cell expansion [173].…”

Section: Cutaneous Squamous Cell Carcinoma Enkephalinmentioning

confidence: 99%

Involvement of the Opioid Peptide Family in Cancer Progression

2023

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Peptides mediate cancer progression favoring the mitogenesis, migration, and invasion of tumor cells, promoting metastasis and anti-apoptotic mechanisms, and facilitating angiogenesis/lymphangiogenesis. Tumor cells overexpress peptide receptors, crucial targets for developing specific treatments against cancer cells using peptide receptor antagonists and promoting apoptosis in tumor cells. Opioids exert an antitumoral effect, whereas others promote tumor growth and metastasis. This review updates the findings regarding the involvement of opioid peptides (enkephalins, endorphins, and dynorphins) in cancer development. Anticancer therapeutic strategies targeting the opioid peptidergic system and the main research lines to be developed regarding the topic reviewed are suggested. There is much to investigate about opioid peptides and cancer: basic information is scarce, incomplete, or absent in many tumors. This knowledge is crucial since promising anticancer strategies could be developed alone or in combination therapies with chemotherapy/radiotherapy.

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Enkephalin loaded and RGD decorated PLGA–poloxamer nanoparticles for effective targeting in cancer cells

et al. 2022

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Methionine enkephalin activates autophagy and stimulates tumour cell immunogenicity in human cutaneous squamous cell carcinoma

Cited by 7 publications

References 57 publications

Opioidergic Signaling—A Neglected, Yet Potentially Important Player in Atopic Dermatitis

Opioidergic Signaling—A Neglected, Yet Potentially Important Player in Atopic Dermatitis

Involvement of the Opioid Peptide Family in Cancer Progression

Enkephalin loaded and RGD decorated PLGA–poloxamer nanoparticles for effective targeting in cancer cells

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