Methionine dependency and cancer treatment

Relationships among MTHFR a1298c Gene Polymorphisms and Methylation Status of Dact1 Gene in Transitional Cell Carcinomas

“…MTHFR converts 5, 10-methylentetrahydrofolate to 5-methyltetrahydrofolate, which is required for homocysteine methylation to methionine. Methionine is then activated to S-adenosylmethionine, a universal methyl donor in numerous transmethylation reactions, including methylation of DNA, RNA, proteins, and other molecules (Cellarier et al, 2003).moreover, enzyme activities with the MTHFR 677TT only met 30 % of that with wild 677CC genotypes, while enzyme activities with the MTHFR 677CT only met 60 % of that with wild 677CC genotypes (Weisberg et al, 1998). changing activity of MTHFR enzyme is associated with polymorphism in MTHFR gene would affect its abilities involving in DNA synthesis and the supply of methyl group, therefore the association between MTHFR gene polymorphism and DNA methylation has gradually drawn interest from many researchers all over the world.…”

Methionine gamma‐lyase: The unique reaction mechanism, physiological roles, and therapeutic applications against infectious diseases and cancers

“…Many cancer cells have an absolute requirement for plasma methionine, whereas normal cells are relatively resistant to the restriction of exogenous methionine (63). Methionine depletion has a broad spectrum of antitumor activities (64).…”

Downregulation of Cdc6 and pre-replication complexes in response to methionine stress in breast cancer cells

“…By contrast, availability of homocysteine does not rescue cancer cells from their methionine dependence. [5][6][7][8] Importantly, remethylation of homocysteine to generate methionine appears to be unaffected in cancer cells. 9 Cancer cell methionine dependency is well-documented.…”