Methionine dependence of tumours: A biochemical strategy for optimizing paclitaxel chemosensitivity in vitro

Pavillard, Valérie; Nicolaou, Anna; Double, John A.; Phillips, Roger M.

doi:10.1016/j.bcp.2005.12.014

Cited by 20 publications

(18 citation statements)

References 19 publications

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“…Cancer cells are often dependent on methionine for proliferation and its presence has been associated with cancer cell growth (30). Strategies of methionine depletion, in attempt to arrest cell cycle growth and improve chemosensitivity, have been reported in both animal models and cancer patients and paclitaxel has recently been shown to have increased activity in methionine-depleted cancer cell lines (31). Gene sets for Sonic Hedgehog Signaling (SHH LISA and SHH Pathway) were enriched for docetaxel resistance in the analysis of the NCI-60 cancer cell lines, an interesting finding given the fact that recent inhibition of these pathways has been associated with increased responsiveness to a number of chemotherapeutic agents, including docetaxel (32,33).…”

Section: Discussionmentioning

confidence: 99%

A genomic approach to identify molecular pathways associated with chemotherapy resistance

Riedel

Porrello

Pontzer

et al. 2008

Molecular Cancer Therapeutics

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Resistance to chemotherapy in cancer is common. As gene expression profiling has been shown to anticipate chemotherapeutic resistance, we sought to identify cellular pathways associated with resistance to facilitate effective combination therapy. Gene set enrichment analysis was used to associate pathways with resistance in two data sets: the NCI-60 cancer cell lines deemed sensitive and resistant to specific chemotherapeutic agents (Adriamycin, cyclophosphamide, docetaxel, etoposide, 5-fluorouracil, paclitaxel, and topotecan) and a series of 40 lung cancer cell lines for which sensitivity to cisplatin and docetaxel was determined. Candidate pathways were further screened in silico using the Connectivity Map. The lead candidate pathway was functionally validated in vitro. Gene set enrichment analysis associated the matrix metalloproteinase, p53, methionine metabolism, and free pathways with cytotoxic resistance in the NCI-60 cell lines across multiple agents, but no gene set was common to all drugs. Analysis of the lung cancer cell lines identified the bcl-2 pathway to be associated with cisplatin resistance and the AKT pathway enriched in cisplatin-and docetaxel-resistant cell lines. Results from Connectivity Map supported an association between phosphatidylinositol 3-kinase/AKT and docetaxel resistance but did not support the association with cisplatin.

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Section: Discussionmentioning

confidence: 99%

A genomic approach to identify molecular pathways associated with chemotherapy resistance

Riedel

Porrello

Pontzer

et al. 2008

Molecular Cancer Therapeutics

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“…In sheep liver, MetR also lowers GH-induced IGF-I gene expression (Stubbs et al 2002). Recent studies also show that MetR stops division of cancer cells (Pavillard et al 2006) and inhibits colon carcinogenesis (Komninou et al 2006). Biogerontology (2008) 9:183-196 191 On the other hand, many studies have shown that excess dietary methionine increases tissue oxidative stress (Mori and Hirayama 2000;Stefanello et al 2005) and we have recently observed that it also increases mitROS production in rat liver (unpublished results).…”

Section: Discussionmentioning

confidence: 89%

“…Moreover, classic studies have repeatedly found that PR also increases maximum longevity in rats and mice (reviewed in Pamplona and Barja 2006), although the magnitude of these increases is around 30-40% that of DR, whereas neither carbohydrate (Khorakova et al 1990) nor lipid restriction (Iwasaki et al 1988;Shimokawa et al 1996) seem to modify rodent longevity. Interestingly, it has been observed that methionine restriction (MetR) without energy restriction also increases maximum longevity in rats and mice (Richie Jr et al 1994;Zimmerman et al 2003;Miller et al 2005) and delays or avoids many age-related changes in rodents (Miller et al 2005;Malloy et al 2006;Pavillard et al 2006). …”

Section: Introductionmentioning

confidence: 98%

Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver

et al. 2008

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Dietary restriction (DR) lowers mitochondrial reactive oxygen species (ROS) generation and oxidative damage and increases maximum longevity in rodents. Protein restriction (PR) or methionine restriction (MetR), but not lipid or carbohydrate restriction, also cause those kinds of changes. However, previous experiments of MetR were performed only at 80% MetR, and substituting dietary methionine with glutamate in the diet. In order to clarify if MetR can be responsible for the lowered ROS production and oxidative stress induced by standard (40%) DR, Wistar rats were subjected to 40% or 80% MetR without changing other dietary components. It was found that both 40% and 80% MetR decrease mitochondrial ROS generation and percent free radical leak in rat liver mitochondria, similarly to what has been previously observed in 40% PR and 40% DR. The concentration of complexes I and III, apoptosis inducing factor, oxidative damage to mitochondrial DNA, five different markers of protein oxidation, glycoxidation or lipoxidation and fatty acid unsaturation were also lowered. The results show that 40% isocaloric MetR is enough to decrease ROS production and oxidative stress in rat liver. This suggests that the lowered intake of methionine is responsible for the decrease in oxidative stress observed in DR.

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“…IC 50 value of 3T3 cells in this study is found to be 1.5. 29 This result indicates that the nanoparticles were able to transport more PTX into the cells, thus achieving greater cytotoxicity with less PTX. Despite the evident cytotoxicity observed in T47D cells, the IC 50 values were higher than earlier reported values.…”

Section: Discussionmentioning

confidence: 91%

Discriminated effects of thiolated chitosan-coated pMMA paclitaxel-loaded nanoparticles on different normal and cancer cell lines

Akhlaghi

Saremi

Ostad

et al. 2010

Nanomedicine: Nanotechnology, Biology and Medicine

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Methionine dependence of tumours: A biochemical strategy for optimizing paclitaxel chemosensitivity in vitro

Cited by 20 publications

References 19 publications

A genomic approach to identify molecular pathways associated with chemotherapy resistance

A genomic approach to identify molecular pathways associated with chemotherapy resistance

Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver

Discriminated effects of thiolated chitosan-coated pMMA paclitaxel-loaded nanoparticles on different normal and cancer cell lines

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