Methionine augments endogenous antioxidant capacity of rice protein through stimulating MSR antioxidant system and activating Nrf2-ARE pathway in growing and adult rats

Li, Hui; Cai, Liang; Liang, Mingcai; Wang, Zhengxuan; Zhang, Yan; Wu, Qiong; Yang, Lin

doi:10.1007/s00217-020-03464-5

Cited by 14 publications

(19 citation statements)

References 41 publications

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“…Supplementation of glutamine to weanling diet can promote the expression of genes related with the reduction of oxidative stress ( 88 ). Similarly, SAAs can control Nrf2 expression in the liver, a transcription factor controlling the expression of antioxidant redox buffering enzymes and the production of other scavenging systems for reactive oxygen species like methionine sulphoxide reductases ( 145 ).…”

Section: Roles Of Amino Acids In Intestinal Homeostasismentioning

confidence: 99%

Functional Amino Acids in Pigs and Chickens: Implication for Gut Health

et al. 2021

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In pigs and broiler chickens, the gastrointestinal tract or gut is subjected to many challenges which alter performance, animal health, welfare and livability. Preventive strategies are needed to mitigate the impacts of these challenges on gut health while reducing the need to use antimicrobials. In the first part of the review, we propose a common definition of gut health for pig and chickens relying on four pillars, which correspond to the main functions of the digestive tract: (i) epithelial barrier and digestion, (ii) immune fitness, (iii) microbiota balance and (iv) oxidative stress homeostasis. For each pillar, we describe the most commonly associated indicators. In the second part of the review, we present the potential of functional amino acid supplementation to preserve and improve gut health in piglets and chickens. We highlight that amino acid supplementation strategies, based on their roles as precursors of energy and functional molecules, as signaling molecules and as microbiota modulators can positively contribute to gut health by supporting or restoring its four intertwined pillars. Additional work is still needed in order to determine the effective dose of supplementation and mode of administration that ensure the full benefits of amino acids. For this purpose, synergy between amino acids, effects of amino acid-derived metabolites and differences in the metabolic fate between free and protein-bound amino acids are research topics that need to be furtherly investigated.

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Section: Roles Of Amino Acids In Intestinal Homeostasismentioning

confidence: 99%

Functional Amino Acids in Pigs and Chickens: Implication for Gut Health

et al. 2021

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“…Methionine is an essential amino acid necessary for normal growth and development in mammals and assumes an important role in many physiological processes, such as metabolism, growth, and immunity [ 6 , 7 ]. Moreover, research continues to validate the critical importance that methionine restriction (MR) plays in decreasing body weight, reducing hepatic lipid levels and reactive oxygen species (ROS) production, increasing hepatic stress resistance, and preventing age-related diseases [ 8 , 9 ]. Even more striking, evidence from animal model studies shows that ROS production and oxidative damage can be reduced by dietary caloric or protein restriction, of which the essential reason is dietary methionine restriction.…”

Section: Introductionmentioning

confidence: 99%

Effect of Dietary Methionine Deficiency Followed by a Re-Feeding Phase on the Hepatic Antioxidant Activities of Lambs

Liu

Diao

Cui

2020

Animals

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Our objective was to investigate the effect of methionine restriction and resuming supply on liver antioxidant response in lambs. The concentrations of methionine and its metabolites and the expression of the nuclear factor erythroid 2-related factor 2 (Nrf2), a redox sensitive factor, were detected after methionine restriction treatment for 50 days and methionine supply recovery for 29 days. The expression of glutathione (GSH) S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) were characterized at the level of transcription and translation. Methionine restriction can directly change the content of methionine and its metabolites in plasma and liver, and affect the redox state of lambs by activating the Nrf2 signaling pathway. Liver tissue can adapt to oxidative environment by upregulating the expression of antioxidant enzymes such as GSH-Px and SOD. Moreover, it was found that there was a lag effect in the recovery of metabolism after methionine supplementation.

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“…In a similar study aiming to elucidate the role of methionine on the antioxidant effect of rice protein (RP) when orally administrated, adult rats were fed with RP and methionine-supplemented RP. Herein, the authors corroborated that methionine activates the Nrf2/ARE pathway through which it augments the endogenous antioxidant capacity of RP [ 184 ]. Moreover, the activation of the Nrf2/ARE pathway by methionine stimulates the expression of methionine reductase and enhances glutathione synthesis which accounts for the augmentation of endogenous antioxidant activity of RP.…”

Section: Nrf2-activating Natural Organosulfur Compoundsmentioning

confidence: 65%

“…Moreover, the activation of the Nrf2/ARE pathway by methionine stimulates the expression of methionine reductase and enhances glutathione synthesis which accounts for the augmentation of endogenous antioxidant activity of RP. Methionine activates Nrf2 by inhibiting Keap1 and Cul3 which results in the up-regulation of ARE-driven antioxidant genes [ 184 ]. This notwithstanding, an entire line of research supports the hypothesis that lower methionine intake reduces ROS generation and increases overall animal longevity.…”

Section: Nrf2-activating Natural Organosulfur Compoundsmentioning

confidence: 99%

The Role of Organosulfur Compounds as Nrf2 Activators and Their Antioxidant Effects

et al. 2022

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Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling has become a key pathway for cellular regulation against oxidative stress and inflammation, and therefore an attractive therapeutic target. Several organosulfur compounds are reportedly activators of the Nrf2 pathway. Organosulfur compounds constitute an important class of therapeutic agents in medicinal chemistry due to their ability to participate in biosynthesis, metabolism, cellular functions, and protection of cells from oxidative damage. Sulfur has distinctive chemical properties such as a large number of oxidation states and versatility of reactions that promote fundamental biological reactions and redox biochemistry. The presence of sulfur is responsible for the peculiar features of organosulfur compounds which have been utilized against oxidative stress-mediated diseases. Nrf2 activation being a key therapeutic strategy for oxidative stress is closely tied to sulfur-based chemistry since the ability of compounds to react with sulfhydryl (-SH) groups is a common property of Nrf2 inducers. Although some individual organosulfur compounds have been reported as Nrf2 activators, there are no papers with a collective analysis of these Nrf2-activating organosulfur compounds which may help to broaden the knowledge of their therapeutic potentials and motivate further research. In line with this fact, for the first time, this review article provides collective and comprehensive information on Nrf2-activating organosulfur compounds and their therapeutic effects against oxidative stress, thereby enriching the chemical and pharmacological diversity of Nrf2 activators.

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Methionine augments endogenous antioxidant capacity of rice protein through stimulating MSR antioxidant system and activating Nrf2-ARE pathway in growing and adult rats

Cited by 14 publications

References 41 publications

Functional Amino Acids in Pigs and Chickens: Implication for Gut Health

Functional Amino Acids in Pigs and Chickens: Implication for Gut Health

Effect of Dietary Methionine Deficiency Followed by a Re-Feeding Phase on the Hepatic Antioxidant Activities of Lambs

The Role of Organosulfur Compounds as Nrf2 Activators and Their Antioxidant Effects

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