Seeds of Citrullus colocynthis were investigated as a possible source of feed or food formulation. The seed contained 13.5% protein (N X 6.25), 26.6% oil, 2.1% ash, 52.9% crude fiber, and 4.9% nitrogen-free extract (NFE). The seeds contained substantial amounts of potassium, phosphorus, and iron. The essential amino acid contents of the seed protein were adequate (>95%) (FAO/WHO, 1973). Lysine was the limiting essential amino acid with a chemical score of 65. The seeds in particular were rich in methionine and cystine (5.5 g/100 g of protein). The in vitro protein digestibility (IVPD) and calculated protein efficiency ratio (C-PER) of the seed protein were 75.9% and 1.85, respectively, on the basis of Animal Nutrition Research Council casein values of 95.0% (IVPD) and 2.50 (C-PER). Feeding experiments with chicks showed normal growth with up to 15% whole seeds in the diet. Using the unprocessed meal however at the same level (15%) depresses growth and feed efficiency.