Methimazole-Induced Jaundice

Fischer, Murry G.

doi:10.1001/jama.1973.03220090048010

Cited by 33 publications

(6 citation statements)

References 6 publications

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“…In a small number of cases of presumed methimazole-induced liver dysfunction, an elevation of bilirubin was the major abnormality and in most of these case reports, mild elevations in liver enzymes and bilirubin occurred within 2 weeks of initiation of methimazole therapy and in liver biopsy specimens preserved hepatocellular architecture along with intracanalicular cholestasis and mild periportal inflammation was observed. Complete, slow recovery is the rule after drug discontinuation [8][9][10][11][12][13][14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

Liver failure due to antithyroid drugs: report of a case and literature review

Livadas

Xyrafis

Economou

et al. 2010

Endocr

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Hyperthyroidism is a common endocrine disorder affecting 2% of females and 0.5% of males worldwide and antithyroid drugs constitute the first line of treatment in the majority of cases. These agents may cause severe adverse effects and among them liver failure, although rare, is a potential lethal one. This case illustrates the sudden and abrupt deterioration of hepatic function due to antithyroid drug administration. This case along with a concise literature review is presented aiming to increase the awareness of endocrinologists of possible fatal complications from the everyday use of common agents such as antithyroid drugs.

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Section: Discussionmentioning

confidence: 99%

Liver failure due to antithyroid drugs: report of a case and literature review

Livadas

Xyrafis

Economou

et al. 2010

Endocr

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“…[14] MMZ-induced jaundice appears to be a hypersensitivity reaction occurring in patients receiving normal doses of the drug. Jaundice due to MMZ is usually associated with cholestatic liver function tests and histological features on liver biopsy of cholestasis and non-specific infiltration of portal tracts with mono-nuclear cells.…”

Section: Jaundice Due To Antithyroid Drugsmentioning

confidence: 99%

“…Jaundice due to MMZ is usually associated with cholestatic liver function tests and histological features on liver biopsy of cholestasis and non-specific infiltration of portal tracts with mono-nuclear cells. [14] Hypersensitivity is suggested by the occasional finding on liver biopsy of eosinophils infiltrating the portal tracts. An elevation of bilirubin is the major abnormality.…”

Section: Jaundice Due To Antithyroid Drugsmentioning

confidence: 99%

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Hyperthyroidism and Jaundice

Bal

Chawla

2010

Indian J Nucl Med

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“…The use of the antithyroid medications, especially thionamide group of drugs (propylthiouracil, methimazole, and carbimazole), in a hyperthyroid patient has been reported to cause hepatic injury. The nature of liver injury associated with the use of antithyroid drugs is drug specific, with propylthiouracil predominantly causing toxic hepatitis and methimazole or carbimazole predominantly causing a cholestatic pattern [ 2 ]. This type of liver dysfunction generally subsides after withdrawal of the offending drug.…”

Section: Introductionmentioning

confidence: 99%

Grave’s Disease with Severe Hepatic Dysfunction: A Diagnostic and Therapeutic Challenge

Bhuyan

Sarma

Saikia

et al. 2014

Case Reports in Medicine

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Hepatic dysfunction in a patient with thyrotoxicosis may result from hyperthyroidism per se, as a side effect of antithyroid drugs, and causes unrelated to hyperthyroidism which sometimes causes diagnostic and therapeutic difficulties. A young female patient was admitted to our hospital with symptoms of thyrotoxicosis, diffuse goiter and ophthalmopathy along with cholestatic pattern of jaundice, and proximal muscle weakness. She was treated with propylthiouracil with gradual recovery. She was continuing her antithyroid medication with regular follow-up. The patient was readmitted a few months later with worsening thyrotoxicosis, proximal muscle weakness, fever, and a hepatocellular pattern of jaundice with sepsis. Propylthiouracil was stopped and lithium along with steroid coverage was given to control her thyrotoxicosis which was later changed to methimazole. Broad spectrum antibiotic therapy was also started but without any response. During her hospital stay, the patient also developed a flaccid paraplegia resembling Guillain-Barre syndrome. IV steroid was started for the neuropathy but meanwhile the patient succumbed to her illness. So in centers where facility for radioiodine therapy is not readily available, some definite well-tested protocols should be formulated to address such common but complicated clinical situations.

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Methimazole-Induced Jaundice

Cited by 33 publications

References 6 publications

Liver failure due to antithyroid drugs: report of a case and literature review

Liver failure due to antithyroid drugs: report of a case and literature review

Hyperthyroidism and Jaundice

Grave’s Disease with Severe Hepatic Dysfunction: A Diagnostic and Therapeutic Challenge

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