Methicillin-susceptible Staphylococcus aureus (MSSA) strains in Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Malaysia: association between agr groups and virulence genes

Sapri, Hassriana Fazilla; Sani, Nurul Azirah Mohamad; Neoh, Hui Min; Hussin, Supyan

doi:10.1016/j.ijid.2012.05.858

International Journal of Infectious Diseases

2012

DOI: 10.1016/j.ijid.2012.05.858

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Methicillin-susceptible Staphylococcus aureus (MSSA) strains in Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Malaysia: association between agr groups and virulence genes

Hassriana Fazilla Sapri

Nurul Azirah Mohamad Sani

Hui Min Neoh

et al.

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2023

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Prevalence and Susceptibility of Staphylococcus aureus Nasal Carriage Strains Isolated from Haemodialysis Patients

Mohd Sukri,

Mohamed,

Isahak

et al. 2023

MJMHS

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Introduction: Staphylococcus aureus is part of the normal human flora that can commonly be found on the skin and mucous membranes of the nasal area. However, in immunosuppressed patients such as those with kidney failures, colonization can potentially lead to infection. There is a concern of increasing antibiotic resistance in S. aureus. This study aimed to determine the prevalence of S. aureus nasal colonization and its antimicrobial susceptibility among haemodialysis-dependent populations. Methods: A cross-sectional study at the Nephrology Unit, Hospital Canselori Tuanku Mukhriz (HCTM) was conducted among haemodialysis-dependent patients between February 2017 to February 2018. Nasal swabs were obtained and cultured on mannitol salt agar. S. aureus isolates were identified by gram staining, tube coagulase and Deoxyribonuclease (DNase). Cefoxitin disc (30 µg) were used to identified the presence of MRSA (methicillin-resistance S. aureus). The S. aureus colonies were further tested against six antibiotics using Kirby Bauer disc diffusion. Result: A total of 134 patients were recruited. S. aureus isolates were detected from 27 patients (20.1%). All S. aureus were phenotypically identified as methicillin-sensitive S. aureus (MSSA) based on the cefoxitin disc. Teicoplanin and linezolid were the most effective with 100% susceptibility. S. aureus exhibited a high resistance rate towards erythromycin (29.6%). No MRSA was isolated in this study. Conclusion: This study highlighted the high prevalence of S. aureus nasal colonization in haemodialysis patients. Teicoplanin and linezolid were found to be the most effective antibiotics against isolated S. aureus.

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Prevalence and Susceptibility of Staphylococcus aureus Nasal Carriage Strains Isolated from Haemodialysis Patients

Mohd Sukri,

Mohamed,

Isahak

et al. 2023

MJMHS

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show abstract

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Methicillin-susceptible Staphylococcus aureus (MSSA) strains in Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Malaysia: association between agr groups and virulence genes

Cited by 1 publication

References 6 publications

Prevalence and Susceptibility of Staphylococcus aureus Nasal Carriage Strains Isolated from Haemodialysis Patients

Prevalence and Susceptibility of Staphylococcus aureus Nasal Carriage Strains Isolated from Haemodialysis Patients

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