Methicillin-resistant Staphylococcus aureus (MRSA) on the skin of long-term hospitalised horses

Eede, Annelies Van den; Hermans, Katleen; Abeele, A. Van den; Floré, Katelijne; Dewulf, Jeroen; Vanderhaeghen, Wannes; Crombé, Florence; Butaye, Patrick; Gasthuys, Frank; Haesebrouck, Freddy; Martens, Ann

doi:10.1016/j.tvjl.2011.12.004

Cited by 34 publications

(23 citation statements)

References 36 publications

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“…Both Dutch and Belgian data thus seem to classify equine CC398 carriage as a primarily veterinary-care associated problem with high detection rates only being found in horses arriving and residing at veterinary clinics. This difference in MRSA prevalence found between horse farms and intensive food production animal facilities seems unlikely to be due to differences in host adaptation given the substantial MRSA carriage found in equine clinics [7,26]. It could, however, be due to differences in husbandry between the examined horse farms and intensive animal husbandry in the same region.…”

Section: Discussionmentioning

confidence: 94%

“…All animals were swabbed both in the nose and at the perianal region using cotton-tipped swabs embedded in solid Stuart’s medium (UNI-TER AMIES CLR, Piove di Sacco, Italy), as previously described [2,3,6,26]. Samples were held at 4°C for a maximum of 24 hours before transfer to the lab.…”

Section: Methodsmentioning

confidence: 99%

“…Although pigs act as the main reservoir, LA-MRSA CC398 has also been shown to be present in other food producing animals, including poultry [21,22] and cattle [23], and it has occasionally been detected in companion animals [24]. In horses, LA-MRSA CC398 is currently regularly being detected in European equine clinics with up to 55% of hospitalized animals testing positive [5-9,25,26]. …”

Section: Introductionmentioning

confidence: 99%

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Low MRSA prevalence in horses at farm level

et al. 2012

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BackgroundIn Europe, methicillin-resistant Staphylococcus aureus (MRSA) belonging to the clonal complex (CC) 398 has become an important pathogen in horses, circulating in equine clinics and causing both colonization and infection. Whether equine MRSA is bound to hospitals or can also circulate in the general horse population is currently unknown. This study, therefore, reports the nasal and perianal MRSA screening of 189 horses on 10 farms in a suspected high prevalence region (East- and West-Flanders, Belgium).ResultsOnly one horse (0.53%) from one farm (10%) tested positive in the nose. It carried a spa type t011-SCCmecV isolate, resistant to β-lactams and tetracycline, which is typical for livestock-associated MRSA CC398.ConclusionIn the region tested here, horses on horse farms seem unlikely to substantially contribute to the large animal associated ST398 MRSA reservoir present at intensive animal production units.

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Section: Discussionmentioning

confidence: 94%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Low MRSA prevalence in horses at farm level

et al. 2012

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“…Staphylococci, including their methicillin-resistant subpopulations, are part of the commensal equine flora. Methicillin-resistant S. aureus (MRSA) have been isolated from the nares of up to 40% of hospitalized horses (Van den Eede et al, 2012) and methicillin-resistant coagulasenegative staphylococci (MR-CNS) from up to 80% of healthy horses (Corrente et al, 2009;Moodley and Guardabassi, 2009). Such previous colonization was identified as risk factor for the development of subsequent clinical disease with MRS (Weese et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

A retrospective analysis of antimicrobial resistance in bacterial pathogens in an equine hospital (2012–2015)

Spijk¹,

Schmitt²,

Fürst³

et al. 2016

SAT

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Antimicrobial resistance has become an important concern in veterinary medicine. The aim of this study was to describe the rate of antimicrobial resistance in common equine pathogens and to determine the occurrence of multidrug-resistant isolates. A retrospective analysis of all susceptibility testing results from bacterial pathogens cultured from horses at the University of Zurich Equine Hospital (2012-2015) was performed. Strains exhibiting resistance to 3 or more antimicrobial categories were defined as multidrug-resistant. Susceptibility results from 303 bacterial pathogens were analyzed, most commonly Escherichia coli (60/303, 20%) and Staphylococcus aureus (40/303, 13%). High rates of acquired resistance against commonly used antimicrobials were found in most of the frequently isolated equine pathogens. The highest rate of multidrug resistance was found in isolates of Acinetobacter baumannii (23/24, 96%), followed by Enterobacter cloacae complex (24/28, 86%) and Escherichia coli (48/60, 80%). Overall, 60% of Escherichia coli isolates were phenotypically ESBL-producing and 68% of Staphylococcus spp. were phenotypically methicillin-resistant. High rates of acquired antimicrobial resistance towards commonly used antibiotics are concerning and underline the importance of individual bacteriological and anti microbial susceptibility testing to guide antimicrobial therapy. Minimizing and optimizing antimicrobial therapy in horses is needed. Keywords: horse, multidrug-resistant (MDR) bacteria, methicillin-resistant staphylococci (MRS), ESBL-producing

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“…and pan‐resistant NDM‐1‐containing Enterobacteriaceae, there is also conclusive evidence of the emergence and impact of resistance in equine patients . Hospitalisation and antimicrobial drug administration have been shown to increase resistance to antimicrobial agents and multidrug resistance of Escherichia coli in equine faeces as well as S. aureus on the skin of horses . With journal article titles such as ‘Critical shortage of new antibiotics in development against multidrug resistant bacteria – time to react is now’ , it raises the question ‘so how should we react?’…”

Section: National Research Council Operative Wound Classificationmentioning

confidence: 99%

Perioperative antimicrobials: Should we be concerned about antimicrobial drug use in equine surgical patients?

Southwood

2014

Equine Veterinary Journal

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Methicillin-resistant Staphylococcus aureus (MRSA) on the skin of long-term hospitalised horses

Cited by 34 publications

References 36 publications

Low MRSA prevalence in horses at farm level

Low MRSA prevalence in horses at farm level

A retrospective analysis of antimicrobial resistance in bacterial pathogens in an equine hospital (2012–2015)

Perioperative antimicrobials: Should we be concerned about antimicrobial drug use in equine surgical patients?

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