Methicillin-resistant Staphylococcus aureus (MRSA) is associated with low within-herd prevalence of intra-mammary infections in dairy cows: Genotyping of isolates

Luini, M.; Cremonesi, Paola; Magro, Giada; Bianchini, Valentina; Minozzi, Giulietta; Castiglioni, Bianca; Piccinini, R.

doi:10.1016/j.vetmic.2015.05.010

Cited by 71 publications

(67 citation statements)

References 25 publications

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“…It is a leading cause of bovine mastitis worldwide [43,77,79,80] and is found occasionally in small ruminants, pigs, and humans. It was determined that the human strains originated from a bovine to human host jump believed to have occurred approximately 40 years ago and subsequently acquired methicillin resistance [81].…”

Section: Cc97mentioning

confidence: 99%

“…CC1/ST1 is one of the major clones circulating in Italy, where it first was reported in pigs [87,88] and dairy cows [43], and seems to be spreading to other countries. In 2009, one strain was detected in Denmark [89], and recently a few strains were discovered in veal calves and pigs in Belgium [29•].…”

Section: Cc1mentioning

confidence: 99%

“…Fortunately, to date and to our knowledge, PVL-positive MRSA CC1 isolates have not yet been isolated from animals; however, typically present are the IEC genes sak and scn, or the enterotoxine gene sea as in human strains, and they also may carry β-hemolysins, LukFLukS, LukD-LukE, LukX-LukY γ-hemolysin, enterotoxin H, and superantigen X [87,90]. The typical strain found in animals belongs to spa type t127 [43,[87][88][89]. MRSA CC1 also has been implicated in mastitis in cows in Italy [43,90].…”

Section: Cc1mentioning

confidence: 99%

“…The typical strain found in animals belongs to spa type t127 [43,[87][88][89]. MRSA CC1 also has been implicated in mastitis in cows in Italy [43,90]. The CC1 strains may carry different SCCmec types, such as SCCmec IV and type 5(5C2).…”

Section: Cc1mentioning

confidence: 99%

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Livestock-Associated MRSA and Its Current Evolution

Butaye

Argudín

Smith

2016

Curr Clin Micro Rpt

116

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Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is a relatively recent phenomenon in veterinary medicine. Although in the beginning it was restricted to a single clonal complex (CC), CC398, it has expanded into several clonal complexes, and the diversity of subtypes in the clonal complexes is increasing also. The prevalence of each type is determined somewhat geographically; for instance, the most prevalent clonal complex in Europe is CC398, whereas in Asia, it is CC9. Although few data exist regarding North America, the situation appears to be mixed there. The SCCmec cassettes detected in LA-MRSA are limited mainly to SCCmec IVa and SCCmec V, although non-typeable cassettes and SCCmec type XI, containing mecC, also have been found.The source of the SCCmec in LA-MRSA was discovered to be animals. In searching from which bacteria the SCCmec cassettes in LA-MRSA have been transferred, the most obvious species to consider are the methicillin-resistant non-S. aureus staphylococci (MRNaS). However, very few data are available from those species in animals, and the data that do exist are not detailed enough to determine the origin. Nevertheless, similar cassettes were found in MRNaS, indicating a possible origin that needs to be investigated further.

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Section: Cc97mentioning

confidence: 99%

Section: Cc1mentioning

confidence: 99%

Section: Cc1mentioning

confidence: 99%

Section: Cc1mentioning

confidence: 99%

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Livestock-Associated MRSA and Its Current Evolution

Butaye

Argudín

Smith

2016

Curr Clin Micro Rpt

116

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“…In Italy, in the last 5 years, the CC97 MRSA lineage has also been increasingly detected in cattle primary production, either from mastitis in dairy cattle or from bulk tank milk (5)(6)(7). Occasionally, CC97 MRSA isolates have been detected in cattle in Germany and Spain.…”

mentioning

confidence: 99%

A Livestock-Associated, Multidrug-Resistant, Methicillin-Resistant Staphylococcus aureus Clonal Complex 97 Lineage Spreading in Dairy Cattle and Pigs in Italy

Feltrin

Alba

Kraushaar

et al. 2016

Appl Environ Microbiol

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S taphylococcus aureus is a major pathogen causing considerable human morbidity and mortality worldwide, and it is a leading cause of infections of some economically important livestock species and, as a prominent bacterial cause of contagious bovine mastitis, a major economic burden for the dairy cattle industry (1). Methicillin-resistant S. aureus (MRSA) lineages are causes of health care-and community-associated infections, which are a major burden of disease on a global scale (2). In the last decade, MRSA sequence type 398 (ST398) has found an ecological niche in the pig, cattle, and poultry industries, although other MRSA lineages (e.g., ST1, ST5, ST9, ST97, ST130, and ST433) have been identified in farmed animals worldwide (3) All these lineages are currently termed "livestock-associated MRSA" (LA-MRSA).The MRSA clonal complex 97 (CC97) lineage has been reported as the second most prevalent MRSA lineage in the Italian pig industry, where spa types t1730 and t4795, both belonging to ST97, were estimated to have colonized 11% of finishing holdings (4). In Italy, in the last 5 years, the CC97 MRSA lineage has also been increasingly detected in cattle primary production, either from mastitis in dairy cattle or from bulk tank milk (5-7). Occasionally, CC97 MRSA isolates have been detected in cattle in Germany and Spain.CC97 is one of the major S. aureus clonal complexes in bovines (8), and recently, a livestock origin of the human pandemic CC97 MRSA strains has been demonstrated, resulting in two emergent human epidemic CC97 community-acquired/associated MRSA (CA-MRSA) clones (8).The aim of this study was to determine the genetic relatedness of MRSA and methicillin-susceptible S. aureus (MSSA) CC97 isolates from pigs and dairy cattle in Italy in the last few years (2008 to 2012) for epidemiological and risk assessment purposes.

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