Methicillin-Resistant Staphylococcus aureus Infection and Treatment Options

Chalmers, Sarah; Wylam, Mark E.

doi:10.1007/978-1-4939-9849-4_16

Cited by 49 publications

(26 citation statements)

References 119 publications

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“…Наиболее высокая летальность наблюдается при внутрибольничной пневмонии, вызванной S. aureus (31,8%) и Klebsiella pneumoniae (35,7%) [12]. Многие из авторов решающую роль в развитии инфекционных деструкций легких отводят неспорообразующей анаэробной флоре, однако есть мнение, что в развитии многих гнойно-деструктивных заболеваний легких участвует полиморфная микрофлора [5,13]. О.О.…”

Section: о возбудителеunclassified

“…В меньшей степени это относится к клиническим проявлениям, которые зачастую схожи. Важным является и факт сочетания определенных факторов патогенности у каждого конкретного штамма бактерии [6,13].…”

Section: о возбудителеunclassified

“…Встречаются варианты постепенной хронизации процесса на фоне повторных пневмонических инфильтратов в тех же долях легких, а также активация ранее перенесенного острого процесса при его неполном обратном развитии во время эпизодов иммуносупрессии (в том числе сезонных вирусных заболеваний) через некоторое время после клинического выздоровления [54]. Профилактика хронического абсцесса заключается в своевременном и адекватном лечении острой бактериальной деструкции легких в условиях специализированных стационаров, а также в квалифицированном наблюдении и лечении пациентов с «сухими» остаточными полостями в легких в условиях терапевтического стационара [5,7,10,13].…”

Section: клиническая картина диагностикаunclassified

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Clinical and radiological variants of lung damage in the infection caused by staphylococcus aureus

Винокуров

Сергеевич²,

Smirnova

et al. 2021

Journal of Clinical Practice

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Despite the high level of modern technologies in the field of laboratory methods and imaging of the respiratory system, the problem of early and accurate differential diagnosis of inflammatory lung diseases remains important in practical medicine. It leads to improved treatment results and a reduction in the number of complications (pleural empyema, fistulas, mediastinitis, sepsis, etc.), and in some cases allows to suspect the presence of a primary purulent source in the body, as in the case of septic pulmonary embolism. The review examines the features of S. aureus as a pathogen of lung diseases, relevant epidemiology, pathogenesis, clinical features and imaging diagnostics of various types of inflammatory changes in the lungs with a focus on destruction.

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Section: о возбудителеunclassified

Section: клиническая картина диагностикаunclassified

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Clinical and radiological variants of lung damage in the infection caused by staphylococcus aureus

Винокуров

Сергеевич²,

Smirnova

et al. 2021

Journal of Clinical Practice

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“…The continuous emergence of methicillinresistant S. aureus (MRSA), including hospital-acquired (HA)-MRSA and communityacquired (CA)-MRSA has caused public health concerns worldwide [3]. Most MRSA isolates are resistant to multiple low-cost antibiotics, which in turn limits therapeutic choices to treat MRSA-associated infections [4]. Therefore, a better understanding of the pathogenesis of S. aureus, including HA-MRSA and CA-MRSA, enables us to develop an alternative strategy to combat MRSA infections.…”

Section: Introductionmentioning

confidence: 99%

Contribution of Coagulase and Its Regulator SaeRS to Lethality of CA-MRSA 923 Bacteremia

et al. 2021

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Coagulase is a critical factor for distinguishing Staphylococcus aureus and coagulase-negative Staphylococcus. Our previous studies demonstrated that the null mutation of coagulase (coa) or its direct regulator, SaeRS, significantly enhanced the ability of S. aureus (CA-MRSA 923) to survive in human blood in vitro. This led us to further investigate the role of coagulase and its direct regulator, SaeRS, in the pathogenicity of CA-MRSA 923 in bacteremia during infection. In this study, we found that the null mutation of coa significantly decreased the mortality of CA-MRSA 923; moreover, the single null mutation of saeRS and the double deletion of coa/saeRS abolished the virulence of CA-MRSA 923. Moreover, the mice infected with either the saeRS knockout or the coa/saeRS double knockout mutant exhibited fewer histological lesions and less neutrophils infiltration in the infected kidneys compared to those infected with the coa knockout mutant or their parental control. Furthermore, we examined the impact of coa and saeRS on bacterial survival in vitro. The null mutation of coa had no impact on bacterial survival in mice blood, whereas the deletion mutation of saeRS or coa/saeRS significantly enhanced bacterial survival in mice blood. These data indicate that SaeRS plays a key role in the lethality of CA-MRSA 923 bacteremia, and that coagulase is one of the important virulence factors that is regulated by SaeRS and contributes to the pathogenicity of CA–MRSA 923.

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“…Staphylococcus aureus is an opportunistic pathogen frequently linked to skin and soft-tissue infections, osteomyelitis, septic arthritis, chronic sinusitis and tonsillitis (Chalmers and Wylam, 2020;Kostić et al, 2020a). In the case of bloodstream infection caused by this bacterium there is a serious concern due to high mortality rates: in the United States among 120000 S. aureus bloodstream infections recorded in 2017, 20000 were with death outcome (Kourtis et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and antibiofilm activity of selected polyphenolic compounds: An in vitro study on Staphylococcus aureus

Kostić¹,

Ivanov²,

Stojković³

et al. 2020

Lekovite sirovine

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Staphylococcus aureus is a human pathogen that causes serious infections with high mortality rates. The antimicrobial activities of eight phenolic compounds (caffeic acid, chlorogenic acid, ferulic acid, morin, quercetin, isoquercitrin, rutin and hesperidin) were evaluated against planktonic and biofilm forming Staphylococcus aureus cells. Their ability to prevent biofilm formation via interference with bacterial cell adhesion and to reduce biomass of 24 h old biofilms has been addressed in this study. The antibacterial activities (MIC/MBC) were demonstrated using the microdilution method and the investigated compounds showed good activity against S. aureus isolates, with MICs in the range 0.05-0.4 mg/mL. Also, they exhibited promising antibiofilm potential in dose depended manner. Among all tested compounds, morin and quercetin showed the best antibiofilm activity at MIC values. The observed antimicrobial potential of the studied natural products can serve as a starting point towards development of novel plant-based therapeutics for the treatment of common infections such as the ones caused by S. aureus.

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Methicillin-Resistant Staphylococcus aureus Infection and Treatment Options

Cited by 49 publications

References 119 publications

Clinical and radiological variants of lung damage in the infection caused by staphylococcus aureus

Clinical and radiological variants of lung damage in the infection caused by staphylococcus aureus

Contribution of Coagulase and Its Regulator SaeRS to Lethality of CA-MRSA 923 Bacteremia

Antibacterial and antibiofilm activity of selected polyphenolic compounds: An in vitro study on Staphylococcus aureus

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