Methicillin‐ResistantStaphylococcus aureus: An Update

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to patients in health care facilities and the community. A MRSA infection can be much more severe than other bacterial infections and can be life-threatening. Resistance to common antibiotics makes treating MRSA costly and difficult. Prolonged hospitalization requiring specialized IV antibiotics also has cost implications. Treatment of MRSA can include use of antibiotics; topical therapies such as honey, topical silver, and gentian violet; and bacteriophages. Research is being conducted on new antibiotics and a MRSA vaccine.

Heterogeneous Macrolide Resistance in Methicillin-Resistant Staphylococcus aureus: Investigation of Resistance Mechanisms and Clonality

“…Özellikle metisiline dirençli S.aureus (MRSA) izolatlarında gittikçe artan oranda görülen çoklu antibiyotik direnci tedavide zorluklara ve maliyet artışına neden olmaktadır. Günümüzde MRSA enfeksiyonlarının tedavisi daha önemli hale gelmiştir 1,2 . Bu amaçla kullanılan başlıca antibiyotikler glikopeptidler ve oksazolidinonlar olup, tetrasiklinler, aminoglikozidler, trimetoprimsülfametoksazol, makrolid, linkozamid ve kinupristin-dalfopristin gibi antibiyotikler de tedavide kullanılan alternatif ajanlardır.…”

Effects of the topical application of an ethyl acetate fraction from Vernonia scorpioides on excisional wounds infected with Staphylococcus aureus in rats

“…Staphylococcus aureus is the most common pathogen in these infections, and the increasing incidence of methicillin-resistant S. aureus (MRSA) over the past two decades has further complicated antibiotic treatment (Nicolau & Stein, 2010). Treatment of MRSA can include use of antibiotics; topical therapies such as honey, topical silver, and gentian violet; and bacteriophages (Durai et al, 2010). In human skin ulcer, a significant increase in MRSA was detected, where S. aureus was the predominant organism (Harrington et al, 2010).…”

Disruption of methicillin-resistant Staphylococcus aureus protein synthesis by tannins

“…1 It also caused the increment of healthcare costs. 2 It causes a diverse range of clinical diseases such as endocarditis, sepsis, skin and soft tissue infections, implanted device1 infections, and several other relevant human diseases. 3,4 Some MRSA have been discovered resistant to new antibiotics such as linezolid, quinupristin/dalfopristin, daptomycin and telavancin [5][6][7] which has limited the drug's effectiveness.…”