Methemoglobin Values in Premature and Mature Infants and Children

Kravitz, Harvey

doi:10.1001/archpedi.1956.02060020003001

Cited by 24 publications

(16 citation statements)

References 11 publications

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“…Methemoglobin represents only 1% of the total hemoglobin of the healthy adult, although it can be slightly higher in preterm and term newborn infants. 19 Obvious cyanosis can occur with methemoglobin concentrations as low as 3% in infants with low hemoglobin concentrations. Symptoms are usually minimal until methemoglobin concentrations exceed 20%.…”

Section: Clinical Manifestationmentioning

confidence: 99%

Infant Methemoglobinemia: The Role of Dietary Nitrate in Food and Water

Greer¹,

Shannon²

2005

Pediatrics

251

122

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ABSTRACT. Infants for whom formula may be prepared with well water remain a high-risk group for nitrate poisoning. This clinical report reinforces the need for testing of well water for nitrate content. There seems to be little or no risk of nitrate poisoning from commercially prepared infant foods in the United States. However, reports of nitrate poisoning from home-prepared vegetable foods for infants continue to occur. Breastfeeding infants are not at risk of methemoglobinemia even when mothers ingest water with very high concentrations of nitrate nitrogen (100 ppm). Pediatrics 2005;116: 784-786; methemoglobinemia.

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Section: Clinical Manifestationmentioning

confidence: 99%

Infant Methemoglobinemia: The Role of Dietary Nitrate in Food and Water

Greer¹,

Shannon²

2005

Pediatrics

251

122

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“…The availability of these compounds in the blood of immature subjects is of particular interest because of certain abnormalities in the erythrocytes of fullterm newborn and prematurely born infants. These abnormalities, which include decreased survival of 51Cr-labeled erythrocytes in premature infants (9,10) and increased susceptibility to Heinz body formation (11) and to methemoglobinemia (12)(13)(14)(15) in both full-term and premature infants, as well as the occurrence of unexplained hemolytic anemias, suggest the possibility of transient biochemical defects in the erythrocytes of these young subjects. Although the activities of the pyridine nucleotide-dependent enzymes in both the glycolytic and shunt pathways are increased in the erythrocytes of young infants (16,17), the levels of the oxidized and reduced coenzymes themselves have not been reported.…”

mentioning

confidence: 99%

Pyridine nucleotides in erythrocyte metabolism.

Gross¹,

Schroeder²,

Gabrio³

1966

J. Clin. Invest.

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In recent years investigations of erythrocyte metabolism have been concerned with the interrelationships of enzymes, coenzymes, substrates, cofactors, and pH, inter alia (1-8). Although data have accumulated on these various aspects of the metabolism of normal and pathological erythrocytes, little direct information has been available heretofore on pyridine nucleotide coenzymes, despite their importance in both the glycolytic and the hexose monophosphate shunt pathways. The availability of these compounds in the blood of immature subjects is of particular interest because of certain abnormalities in the erythrocytes of fullterm newborn and prematurely born infants. These abnormalities, which include decreased survival of 51Cr-labeled erythrocytes in premature infants (9, 10) and increased susceptibility to Heinz body formation (11) and to methemoglobinemia (12-15) in both full-term and premature infants, as well as the occurrence of unexplained hemolytic anemias, suggest the possibility of transient biochemical defects in the erythrocytes of these young subjects. Although the activities of the pyridine nucleotide-dependent enzymes in both the glycolytic and shunt pathways are increased in the erythrocytes of young infants (16,17), the levels of the oxidized and reduced coenzymes themselves have not been reported.In the present study the concentrations of DPN,l

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“…In normal adults methemoglobin levels average 0.82% of the total hemoglobin, with a range of 0 to 1.9% [6]. Slightly higher [12]. In hereditary methemoglobinemia, homozygotes have levels of methemoglobin gene rally exceeding 10% and they may even be as high as 60 to 70% of the total hemoglobin in severely affected children.…”

Section: Discussionmentioning

confidence: 99%