Methemoglobin measure in adult patients with sickle-cell anemia: influence of hydroxyurea therapy

Laurentino, Marilia Rocha; Carvalho, Tereza Cristina de; Santos, Talyta Ellen de Jesus dos; Barbosa, Maritza Cavalcante; Gonçalves, Raquel

doi:10.5935/1676-2444.20140013

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…HU therapy was also observed to significantly reduce HbS levels, which is consistent with results by Shome et al who also found an association between HU use and significantly reduced HbS levels in SCA patients [ 38 ]. We also detected significantly higher HbF levels in SCA-HU + patients compared to controls, which confirms results in previous studies regarding the efficacy of HU in inducing HbF synthesis [ 3 , 34 , 39 , 40 ].…”

Section: Discussionsupporting

confidence: 90%

Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters

et al. 2018

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This study investigated associations between SNPs in genes encoding metabolizing drug enzymes and laboratory parameters in sickle cell anemia patients under hydroxyurea (SCA-HU+). We evaluated hematologic and biochemical parameters by electronic methods and SNPs by PCR-RFLP and multiplex PCR in 35 SCA-HU+ patients and 67 SCA-HU− patients. The HbS, total cholesterol, lactate dehydrogenase, aspartate aminotransferase, total bilirubin and fractions levels, and leukocyte, eosinophil, monocyte, and erythroblast counts were reduced in SCA-HU+ patients (p < 0.05). Moreover, they presented higher HbF, C-reactive protein, and ferritin levels and elevated MCH and MCV values (p < 0.05). Genotype frequencies of variants GA + AA of MPO −463G>A and c1c2 + c2c2 of CYP2E1 −1293G>C/−1053C>T were higher in SCA-HU+ patients (p < 0.05). Independent associations were found between the variant A allele and lower total cholesterol, between c2 allele and low alpha-1 antitrypsin and between the null GSTT1 variant and high indirect and total bilirubin in SCA-HU+ patients. In SCA-HU− patients, independent associations were found between the variant A allele and high uric acid and between c2 allele and high urea. Our results suggest that SNPs MPO −463G>A, CYP2E1 −1293G>C/−1053C>T, and GSTT1 can be associated with alterations in lipid, inflammatory, renal, hemolytic, and hepatic profiles. However, further studies are needed to elucidate these associations.

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Section: Discussionsupporting

confidence: 90%

Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters

et al. 2018

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“…NADPH oxidases are not the only intracellular sources of ROS. Normal cellular metabolism produces hydrogen peroxide (H 2 O 2 ) (examples: peroxisomal oxidases that convert O 2 to H 2 O 2 ; the cytochrome P450 system [ 1 ]; xanthine oxidase reaction and certain stressful or pathological conditions produce superoxide, and indirectly H 2 O 2 [examples: aged mitochondria through “leakage” of single electrons in complexes I and III [ 2 ]; production of methemoglobin in certain mutant hemoglobins like HbS [ 3 ]]. Additionally, deleterious ROS are also produced by biogenic and non-biogenic environmental attacks from outside [for instance as a secondary consequence of ionizing radiation, IR], leading to oxidative stress).…”

Section: Introductionmentioning

confidence: 99%

The defense and signaling role of NADPH oxidases in eukaryotic cells

Breitenbach

Rinnerthaler

Weber

et al. 2018

Wien Med Wochenschr

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SummaryThis short review article summarizes what is known clinically and biochemically about the seven human NADPH oxidases. Emphasis is put on the connection between mutations in the catalytic and regulatory subunits of Nox2, the phagocyte defense enzyme, with syndromes like chronic granulomatous disease, as well as a number of chronic inflammatory diseases. These arise paradoxically from a lack of reactive oxygen species production needed as second messengers for immune regulation. Both Nox2 and the six other human NADPH oxidases display signaling functions in addition to the functions of these enzymes in specialized biochemical reactions, for instance, synthesis of the hormone thyroxine. NADPH oxidases are also needed by Saccharomyces cerevisiae cells for the regulation of the actin cytoskeleton in times of stress or developmental changes, such as pseudohyphae formation. The article shows that in certain cancer cells Nox4 is also involved in the re-structuring of the actin cytoskeleton, which is required for cell mobility and therefore for metastasis.

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Dalcetrapib and reduced glutathione effect on hemoglobin S polymerization studied by NMR

et al. 2022

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Methemoglobin measure in adult patients with sickle-cell anemia: influence of hydroxyurea therapy

Cited by 3 publications

References 19 publications

Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters

Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters

The defense and signaling role of NADPH oxidases in eukaryotic cells

Dalcetrapib and reduced glutathione effect on hemoglobin S polymerization studied by NMR

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