Methemoglobin Formation by Aminophenol and Diphenol in Rabbits

Kusumoto, Shigeko; Nakajima, Taichi

doi:10.2486/indhealth.2.133

Cited by 3 publications

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“…Acalypha indica is composed of various phytochemicals (Table 3) and nutrients which most of them play a role in human therapeutic property. 1 On the other hand, previous studies have implicated three constituents found in leaf and the whole parts of this plant; quinine, 15 2-methyl anthraquinone and tectoquinone 16 resulting in methemoglobinemia (Table 3). These constituents might have oxidative potentials.…”

Section: Discussionmentioning

confidence: 91%

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Clinical Characteristics of Acalypha indica Poisoning

Pradoo

Sriapha

Trakulsrichai

et al. 2020

IJGM

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Background: Acalypha indica is a tropical plant used as a herbal medicine in various parts of the world, including Thailand. In glucose-6-phosphate dehydrogenase (G6PD)-deficient patients, acute hemolysis has been reported following the ingestion of this plant. Methemoglobinemia was reported in the present study. Patients and Methods: Descriptive data of patients who suffered from Acalypha indica toxicity reported from different hospitals to the Ramathibodi Poison Center were retrieved from 2011 to 2019. Results: Eight patients were included, mostly male with a median age of 61.5 years. The plant was ground for fresh juice or boiled before consuming as herbal medicine. All patients presented with dark urine. Most had jaundice and fever, and all reported hemolysis. Seven out of eight patients were diagnosed as methemoglobinemia. Methemoglobin level was confirmed in five patients with the highest level of 23.9%. Early symptoms occurred within 24 hours of the last ingested dose. Discussion: In previous case reports of Acalypha indica ingestion, acute hemolysis was mostly observed in G6PD-deficient patients, consistent with the current findings. However, our patients also demonstrated methemoglobinemia, with some constituents in this plant (quinine, 2-methyl anthraquinone and tectoquinone) implicated as the cause in previous studies. Further studies are crucial to validate these findings. Conclusion: We report a case series in which acute hemolysis and methemoglobinemia after Acalypha indica ingestion were observed. This study presents methemoglobinemia as the other toxicity caused by this plant.

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Section: Discussionmentioning

confidence: 91%

“…Oxidative chemicals may cause both acute hemolysis and methemoglobinemia. [15][16][17] Although this plant contains cyanogenic glycosides and hydrogen cyanide, no patient developed or demonstrated any signs/symptoms of cyanide poisoning.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Acalypha indica Poisoning

Pradoo

Sriapha

Trakulsrichai

et al. 2020

IJGM

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“…Even though, there are limited literature, it is commonly used in Aurvedic medical remedies in Sri Lanka. Out of all those phytochemicals, it has been documented that quinine, tectoquinone and 2 methyl anthraquinone has the capacity to induce some oxidative stress to the humans [9], which can lead to acute intravascular hemolysis (Figure 3) and methemoglobinemia [10,11].…”

Section: Discussionmentioning

confidence: 99%

A Case Report of Acute Oxidative Haemolysis Following Medicinal Plant Ingestion in a Patient with G6PD Deficiency

Fernando,

Williams

et al. 2024

Preprint

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Introduction Acalypha indica (AI) is an Ayurvedic medicinal plant. Some of this plant’s phytochemicals have been reported to cause oxidative stress in red blood cells. However, we know very little about those chemicals due to a dearth of literature. We present a case in which a patient with a previously unidentified glucose-6-phosphate dehydrogenase (G6PD) deficiency experienced acute hemolysis after ingesting fresh AI plant leaves. Case Presentation A 65-year-old man presented with jaundice, pallor, and haematuria following ingestion of the "Kuppamenia mallum" dish. His peripheral blood picture showed bite cells and Heinz bodies. A positive Brewer's test raised the clinical suspicion of G6PD deficiency. Low values of the G6PD level assessment at the follow-up visit confirmed the diagnosis. Conclusion Although AI is regarded as a medicinal plant, acute hemolysis can also occur after consumption in G6PD-deficient patients. This case emphasises the need for further research to identify the phytochemicals and their concentrations that can induce toxicity.

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Methemoglobin formation by nitrobenzene in vitro

Kusumoto

Nakajima

1970

Naunyn-Schmiedebergs Arch. Pharmak.

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Methemoglobin Formation by Aminophenol and Diphenol in Rabbits

Cited by 3 publications

References 0 publications

<p>Clinical Characteristics of <em>Acalypha indica</em> Poisoning</p>

<p>Clinical Characteristics of <em>Acalypha indica</em> Poisoning</p>

A Case Report of Acute Oxidative Haemolysis Following Medicinal Plant Ingestion in a Patient with G6PD Deficiency

Methemoglobin formation by nitrobenzene in vitro

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