Methcathinone Increases Visually-evoked Neuronal Activity and Enhances Sensory Processing Efficiency in Mice

Zhou, Jun; Deng, Wen; Chen, Chen; Kang, Junya; Yang, Xiaodan; Dou, Zhaojuan; Wu, Jiumn-Yih; Li, Quancong; Jiang, Man; Liang, Man; Han, Yunyun

doi:10.1007/s12264-022-00965-z

Cited by 2 publications

(1 citation statement)

References 51 publications

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“…For in vivo imaging of ACC neurons, a cranial window was implanted in all mice before behavioral training as described before 43 . rAAV 2/R -mCherry (50 nL, 10 12 VP ml −1 , BrainVTA) were injected into the retrosplenial cortex (RSP, AP: −2.7 mm; ML: −1 mm; DV: −0.5 mm; Allen Mouse Brain Atlas) at a rate of 5 nL min −1 via a calibrated glass pipette (5 μL microcapillary tube; Sigma-Aldrich) connected to a pneumatic picopump (SYS-PV830, WPI).…”

Section: Methodsmentioning

confidence: 99%

Anterior cingulate cortex provides the neural substrates for feedback-driven iteration of decision and value representation

Chen,

Liang,

et al. 2024

Nat Commun

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Adjusting decision-making under uncertain and dynamic situations is the hallmark of intelligence. It requires a system capable of converting feedback information to renew the internal value. The anterior cingulate cortex (ACC) involves in error and reward events that prompt switching or maintenance of current decision strategies. However, it is unclear whether and how the changes of stimulus-action mapping during behavioral adaptation are encoded, nor how such computation drives decision adaptation. Here, we tracked ACC activity in male mice performing go/no-go auditory discrimination tasks with manipulated stimulus-reward contingencies. Individual ACC neurons integrate the outcome information to the value representation in the next-run trials. Dynamic recruitment of them determines the learning rate of error-guided value iteration and decision adaptation, forming a non-linear feedback-driven updating system to secure the appropriate decision switch. Optogenetically suppressing ACC significantly slowed down feedback-driven decision switching without interfering with the execution of the established strategy.

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Section: Methodsmentioning

confidence: 99%

Anterior cingulate cortex provides the neural substrates for feedback-driven iteration of decision and value representation

Chen,

Liang,

et al. 2024

Nat Commun

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Why it hurts: with freedom comes the biological need for pain

Farnsworth

Elwood

2023

Anim Cogn

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We argue that pain is not needed to protect the body from damage unless the organism is able to make free choices in action selection. Then pain (including its affective and evaluative aspects) provides a necessary prioritising motivation to select actions expected to avoid it, whilst leaving the possibility of alternative actions to serve potentially higher priorities. Thus, on adaptive grounds, only organisms having free choice over action selection should experience pain. Free choice implies actions must be selected following appraisal of their effects, requiring a predictive model generating estimates of action outcomes. These features give organisms anticipatory behavioural autonomy (ABA), for which we propose a plausible system *

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Methcathinone Increases Visually-evoked Neuronal Activity and Enhances Sensory Processing Efficiency in Mice

Cited by 2 publications

References 51 publications

Anterior cingulate cortex provides the neural substrates for feedback-driven iteration of decision and value representation

Anterior cingulate cortex provides the neural substrates for feedback-driven iteration of decision and value representation

Why it hurts: with freedom comes the biological need for pain

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