Methanotroph (Methylococcus capsulatus, Bath) bacteria meal alleviates soybean meal-induced enteritis in spotted seabass (Lateolabrax maculatus) by modulating immune responses and the intestinal flora

Zhang, Jian; Yu, Manhan; Wang, Jia; Longshaw, Matt; Song, Kai; Wang, Ling; Li, Xueshan; Zhang, Chunxiao; Lu, Kangle

doi:10.1016/j.aquaculture.2023.739795

Cited by 9 publications

(2 citation statements)

References 99 publications

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“…Legume-based feeds, such as those derived from soybeans (Knudsen et al, 2008), peas (Penn et al, 2011) and faba beans (De Santis et al, 2015), are known to induce gut inflammation and enteropathy. This inflammation, however, has also been shown to be alleviated by the inclusion of M. capsulatus in diets of Lateolabrax maculatus and Atlantic salmon (Romarheim et al, 2013;Zhang et al, 2023). Continuous improvements in aquafeed formulation have decreased the incidence of diet-induced gut enteritis in Atlantic salmon (Agboola et al, 2022), but gastrointestinal health still remains one of the most common diseases in intensive aquaculture.…”

Section: Discussionmentioning

confidence: 99%

Replacement of fishmeal with a microbial single‐cell protein induced enteropathy and poor growth outcomes in barramundi (Lates calcarifer) fry

Samsing,

Sullivan,

Truong

et al. 2024

Journal of Fish Diseases

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Fish meal (FM) replacement is essential for the sustainable expansion of aquaculture. This study focussed on the feasibility of replacing FM with a single‐cell protein (SCP) derived from methanotrophic bacteria (Methylococcus capsulatus, Bath) in barramundi fry (Lates calcarifer). Three isonitrogenous and isoenergetic diets were formulated with 0%, 6.4% and 12.9% inclusion of the SCP, replacing FM by 0%, 25% and 50%. Barramundi fry (initial body weight 2.5 ± 0.1 g) were fed experimental diets for 21 days to assess growth performance, gut microbiome composition and gut histopathology. Our findings revealed that both levels of SCP inclusion induced detrimental effects in barramundi fry, including impaired growth and reduced survival compared with the control group (66.7% and 71.7% survival in diets replacing FM with SCP by 25% and 50%, respectively; p < .05). Both dietary treatments presented mild necrotizing enteritis with subepithelial oedema and accumulation of PAS positive, diastase resistant droplets within hepatocytes (ceroid hepatopathy) and pancreatic atrophy. Microbiome analysis revealed a marked shift in the gut microbial community with the expansion of potential opportunistic bacteria in the genus Aeromonas. Reduced overall performance in the highest inclusion level (50% SCP) was primarily associated with reduced feed intake, likely related to palatability issues, albeit pathological changes observed in gut and liver may also play a role. Our study highlights the importance of meticulous optimization of SCP inclusion levels in aquafeed formulations, and the need for species and life‐stage specific assessments to ensure the health and welfare of fish in sustainable aquaculture practices.

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Section: Discussionmentioning

confidence: 99%

Replacement of fishmeal with a microbial single‐cell protein induced enteropathy and poor growth outcomes in barramundi (Lates calcarifer) fry

Samsing,

Sullivan,

Truong

et al. 2024

Journal of Fish Diseases

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“…Table 4 summarizes recent feed trials where BPM has been to replace traditional protein sources. Attempts have been made to replace FM and SBM with BPM in the diets of aquatic species (Biswas et al, 2020;Zhang et al, 2023), broilers (Schoyen et al, 2007), and pigs (Overland et al, 2001). Studies indicate that BPM can partially substitute for protein components in feed without affecting growth performance; however, it impacts various aspects, such as animal fat, gut microbial communities, immunity, and feed digestibility, to varying degrees.…”

Section: Quality and Securitymentioning

confidence: 99%

Methanotroph biotransformation for nutrient recovery: a review of current strategies and future opportunities

Zheng,

Liu,

Khademi

et al. 2024

Biofuel Res. J.

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The escalating global demand for protein and the imperative to meet sustainable development goals have driven the emergence of biotransformation platforms, with methanotrophs showing significant potential in this field. In this paper, the metabolism, nutritional requirements, cultivation strategies, and bioreactors of methanotrophs are reviewed. Integrating upstream and downstream technologies is also advocated to advance the development of methanotroph biotransformation platforms toward a circular economy model. The advancements in utilizing biogas as a viable carbon source and wastewater as a nitrogen source are discussed, emphasizing the need for detailed quality control and safety assessments to ensure the suitability of single-cell protein as animal feed. In general, by integrating advanced nutrient recovery technologies to define new process routes, methanotroph biotransformation platforms can bring better environmental benefits by reducing carbon emissions and saving resources. Shifting to renewable energy is crucial for achieving environmental sustainability. By using renewable energy to power microbial fermentation, biomass dehydration, and waste recycling, the platform can offset high energy consumption and attain significant market competitiveness with traditional protein sources.

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The effect of dietary supplementation with Lactobacillus rhamnosus GCC-3 fermentation product on gut and liver health of common carp (Cyprinus carpio)

Chen,

Zhang,

Xie

et al. 2024

Aquaculture Reports

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Methanotroph (Methylococcus capsulatus, Bath) bacteria meal alleviates soybean meal-induced enteritis in spotted seabass (Lateolabrax maculatus) by modulating immune responses and the intestinal flora

Cited by 9 publications

References 99 publications

Replacement of fishmeal with a microbial single‐cell protein induced enteropathy and poor growth outcomes in barramundi (Lates calcarifer) fry

Replacement of fishmeal with a microbial single‐cell protein induced enteropathy and poor growth outcomes in barramundi (Lates calcarifer) fry

Methanotroph biotransformation for nutrient recovery: a review of current strategies and future opportunities

The effect of dietary supplementation with Lactobacillus rhamnosus GCC-3 fermentation product on gut and liver health of common carp (Cyprinus carpio)

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