Methanolic Root Extract of Rauwolfia serpentina Lowers Atherogenic Dyslipidemia, Arteriosclerosis and Glycosylation Indices in Type 1 Diabetic Mice

Azmi, Muhammad Bilal; Qureshi, Shamim A.; Rais, Sumera; Sultana, Sayeeda

doi:10.7324/japs.2015.50810

Cited by 6 publications

(7 citation statements)

References 21 publications

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“…After the acclimatization period, alloxan monohydrate was used to induce diabetes in rats through a single intra-peritoneal injection of a freshly prepared solution in normal saline at a dose of 150 mg/kg body weight once a day for three successive days (Azmi et al 2015).…”

Section: Preparation and Administration Of Drug Inducermentioning

confidence: 99%

“…It was kept overnight at room temperature. The supernatant was collected and evaporated to dryness using a rotary evaporator (Heidolph) and the final residue was lyophilized using a lyophilizer (Azmi et al 2015;Ashwini et al 2015;Nicolas et al 2016).…”

Section: Preparation Of Different Treatmentsmentioning

confidence: 99%

“…Serpentina is a small annual shrub belonging to the family Apocynaceae that grows erect to a height of 30-110 cm in moist and shady places with a dark green slender stem, lance-shaped leaves with hairless blades measuring up to 2 cm long by 2.5 cm wide (Kumar et al 2012). Known for its diversified ethnomedicinal usefulness, serpentina can cure snake bites, gastrointestinal tract disorders, breast cancer, and skin problems (Azmi et al 2015). Many present studies emphasize the potential of serpentina as an anti-fungal, anti-inflammatory, anti-oxidant, anti-proliferative, anti-cancerous, anti-diuretic, anti-dysentery, and tranquilizing agent (Malviya and Sason 2016).…”

Section: Introductionmentioning

confidence: 96%

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Effects of Rauwolfia serpentina L. Benth. ex Kurz (Serpentina) and Costus igneus Nak. (Insulin plant) leaves crude extracts on the blood glucose levels of alloxan induced albino rats

Fauni-Guirre¹,

Ching

2022

J Exp Bio & Ag Sci

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The prevalence of treatment failures from dietary patterns and oral medications associated with diabetes have generated adverse effects and are oftentimes expensive. Recently, food-based therapies such as Rauwolfia serpentina (serpentina) and Costus igneus (insulin plant) have been received much attention due to the urge for an alternative and safe solution against diabetes. Thus, the hypoglycemic effects of serpentina and insulin plant leaf crude extracts were determined on the blood glucose level of test rats. Twenty-four alloxan-induced male albino rats were subjected to this experimental study distributed into six groups in a completely randomized design. The negative control (NEG) comprised of diabetic rats receiving no treatment; while the positive control (MET) comprised of diabetic rats treated with metformin; experimental groups include IN1X and IN2X for the diabetic rats treated with extracts of insulin plant leaves administered once and twice daily and SER1X and SER2X for the diabetic rats treated with extracts of serpentina leaves administered once and twice daily. Results of the study revealed that both serpentina and insulin plant leaves crude extract demonstrated hypoglycemic effects due to the presence of zinc that potentiated insulin action. Further, the insulin plant improved glucose and insulin levels due to quercetin which reduced oxidative stress and protects DNA damage, β-amyrin and β-L-arabinose methyl glucoside which builds-up insulin for glucose metabolism. The presence of significant phytochemical contents in the insulin plant has been attributed to the stimulation of β cells. In conclusion, insulin plant leaf crude extract elucidated better hypoglycemic activity than the serpentina plant leaf crude extract in the blood glucose levels of alloxan-induced diabetic rats.

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Section: Preparation and Administration Of Drug Inducermentioning

confidence: 99%

Section: Preparation Of Different Treatmentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Effects of Rauwolfia serpentina L. Benth. ex Kurz (Serpentina) and Costus igneus Nak. (Insulin plant) leaves crude extracts on the blood glucose levels of alloxan induced albino rats

Fauni-Guirre¹,

Ching

2022

J Exp Bio & Ag Sci

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“…The obtained results highlighting therapeutic potential of MREt in lowering the risk of atherogenic dyslipidemia, arteriosclerosis and glycosylation in alloxaneinduced diabetic mice. [31] …”

Section: In Vivo Studiesmentioning

confidence: 99%

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Kaur¹

2017

IJGP

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Rauwolfia serpentina has been used since pre-vedic period for the treatment of snake bite (sarpadansh), insect stings, hypertension (Rakta Capa Vriddhi), insomnia (anidra), psychological disorders (manovikar), gastrointestinal disorders (Amashay gata roga), epilepsy (apasmar), wounds (vrana), fever (jwara), and schizophrenia (unmada). It is a large glabrous herb or shrub, belonging to family Apocynaceae, and found in the Assam, Pegu, Himalayas, Java, Tennasserim, Deccan, Peninsula, Bihar, and the Malay Peninsula. It is a source of many phytoconstituents including alkaloids, carbohydrates, flavonoids, glycosides, phlobatannins, phenols, resins, saponins sterols, tannins, and terpenes. The main alkaloid of R. serpentina is reserpine. It exerts antihypertensive property by depleting the catecholamine which is the main action of the plant. Besides, many studies have been describing multidimensional pharmacological activities of the R. serpentina. Hence, the present review describes ancient to modern approach based on pharmacobotanical and pharmacological studies of R. serpentina.

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“…Diabetes Mellitus (DM) is a metabolic disorder characterized by high levels of blood glucose due to defects in insulin secretion and/or insulin action (Azmi et al, 2015). Chronic hyperglycemia can cause some complications, including cardiac and renal dysfunction and difficult-to-treat infection (Guo et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

The Increased Expressions of Type IV Collagen in Cochlear Fibroblasts of Diabetic Rat Models Caused by Curcumin Therapy

Haryuna¹,

Farhat²,

Taufika³

et al. 2017

J App Pharm Sci

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Damage to fibroblasts within the cochlear lateral wall is suggested as one of the causes of hearing loss in patients with diabetes mellitus. The aim of this study was to prove curcumin as a safe and effective substance to treat the cochlear fibroblasts damage measured by the expressions of type IV collagen. Twenty-four Rattus norvegicus were randomly divided into 6 groups (n=4). Group I: the control group; group II: the diabetic group; group III and IV: the diabetic groups received curcumin therapy 200 and 400 mg/kgBW/day from day 3 -5; group V and VI: the diabetic groups received curcumin therapy 200 and 400 mg/kgBW/day from day 3 -10. Curcumin [16.62 ± 0.14]% w/w compared to Standard was administered orally, derived from Curcuma longa Linnaeus (turmeric). All samples were immunohistochemistrically examined for the expressions of type IV collagen in cochlear fibroblasts. Statistically significant differences were found for the expressions of type IV collagen (p<0.05) between group I and II, group II and V, and group II and VI. Curcumin proved to be potentially effective in the treatment of damage to cochlear fibroblasts regarding the increased expression of type IV collagen in diabetic rat models.

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Methanolic Root Extract of Rauwolfia serpentina Lowers Atherogenic Dyslipidemia, Arteriosclerosis and Glycosylation Indices in Type 1 Diabetic Mice

Cited by 6 publications

References 21 publications

Effects of Rauwolfia serpentina L. Benth. ex Kurz (Serpentina) and Costus igneus Nak. (Insulin plant) leaves crude extracts on the blood glucose levels of alloxan induced albino rats

Effects of Rauwolfia serpentina L. Benth. ex Kurz (Serpentina) and Costus igneus Nak. (Insulin plant) leaves crude extracts on the blood glucose levels of alloxan induced albino rats

Untitled

The Increased Expressions of Type IV Collagen in Cochlear Fibroblasts of Diabetic Rat Models Caused by Curcumin Therapy

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