Methanolic extract of tetracera potatoria, an antiulcer agent increases gastric mucus secretion and endogenous antioxidants

Abstract

Summary: In this study, the possible mechanism underlying the antiulcer activity of the methanolic extract of the root of Tetracera potatoria (MeTp) was studied in albino rats. Misoprostol and omeprazole were used as reference drugs. The animals had MeTp administered to them at varying doses of 100, 400 and 800 mg/kg for 15 days. MeTp significantly (P<0.05) increased gastric mucus secretion and gastric mucus cell counts when compared to control. MeTp treated animals also showed significant (P<0.05) increase in the activity of superoxide dismutase (SOD) with concurrent decrease in the level of malonialdehyde (MDA) with respect to control. These findings suggest that part of the gastroprotective property of MeTp is associated with the ability of the extract to cause stimulation of gastric mucus secretion through increased number of gastric mucus cells. Increased SOD-activity and decreased MDAlevels further lend support to its gastroprotective effect.

Mechanisms of Gastroprotective Effects of Ethanolic Leaf Extract ofJasminum sambacagainst HCl/Ethanol-Induced Gastric Mucosal Injury in Rats

“…The pathogenesis of ethanol-induced gastric mucosal damage occurs directly and indirectly through various mediators such lipoxygenase, cytokines, and oxygen-derived free radicals [32]. Mucus secretion is regarded as a crucial defensive factor in the protection of the gastric mucosa from gastric lesions [33]. …”

Antiulcer Activity of Indigenous PlantOperculina turpethumLinn.

“…H 2 blockers like cimetidine, ranitidine, and famotidine exhibit antihistaminic effect thus causing reduction in gastric acidity and secretory volume since they have a five-membered ring structure with a flexible side chain attached to polar uncharged group. Evidently, betulinic acid an active constituent in both the extracts having similar ring structure to H 2 blockers may be a reason for the antihistaminic effect, which is responsible for gastroprotective nature [39, 40]. Moreover, betulinic acid, lupeol, betulin, and glycosides [31, 41–44] present in the extracts possess potent antioxidant properties by decreasing lipid peroxidation and increasing antioxidant levels.…”

Ulcer Healing and Gastroprotective Activity of Methanolic Extracts of Hyoscyamus Albus and Umbilicus Rupestris Leaves against Gastric Injury Caused by Ethanol in Rats

“…In fact major, the compounds are known by their antiulcer effects by inhibition of the lesions of the gastric mucous membrane [18]. It was also reported that the flavonoïds ensures a protection against gastric cancer [19,20].…”