“…For thousands of years, Chansu, an aqueous extract obtained from the post-auricular and skin glands of Bufo chansa gargarizans Cantor, has been used as a Traditional Chinese Medicine for the treatment of various conditions, such as swelling, pain, and heart failure and, more recently, for cancers of the liver, lung, colon, pancreas and stomach (19)(20)(21). In Brazil, the most extensively studied amphibian-derived skin secretions are from Rhinella marina (R. marina; Cururu toad), which contains compounds, such as marinobufagin, telecinobufagin, bufalin, marinobufotoxin, cholesterol, dehydrobufotenine, and suberoyl arginine (2,22,23). A variety of biological effects have been attributed to the compounds in R. marina skin secretions extracts, including cytotoxic, immunomodulatory, antifungal, antimutagenic, and anti-plasmodial activities (9)(10)(11)(22)(23)(24)(25).…”