Methanolic extract of Marrubium vulgare ameliorates hyperglycemia and dyslipidemia in streptozotocin-induced diabetic rats

Elberry, Ahmed A.; Harraz, Fathalla M.; Ghareib, Salah A.; Gabr, Salah A.; Nagy, Ayman A.; Abdel‐Sattar, Essam

doi:10.1016/j.ijdm.2011.01.004

Cited by 97 publications

(70 citation statements)

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“…A significant decrease (P≤0.05) in mean serum glucose concentration and significant increase (P≤0.05) in serum insulin level were also observed in all treatment groups in comparison to diabetic group. Previous researchers (Elberry et al, 2015;Jayachandran et al, 2018) have also described decline in mean insulin level in diabetic rats as observed in the current experiment. In another study, it was observed that serum insulin level was higher in diabetic rats fed on high protein diet compared to those receiving normal diet (Eizirik et al, 1986).…”

Section: Discussionsupporting

confidence: 86%

High Protein Diet Improves Biochemical and Metabolic Hormonal Profile in Alloxan-Induced Diabetic Rats

Muzaffar¹

2019

PVJ

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Diabetes mellitus is a metabolic disorder characterized by high blood glucose level due to defective insulin secretion or action and is considered one of the major concerns to human health all over the world. Current study was planned to assess the effects of protein rich diet on body weight, glycemic control, insulin levels in hyperglycemic rats. For this purpose, high protein diet (45% or 55% fish protein rich in omega 3 fatty acids) was administered to alloxan-induced diabetic rats for a period of 28 days. Blood samples were collected for monitoring glucose level, serum insulin level and thyroid hormone levels. Alloxan administration resulted in reduced body weight, increased blood glucose, leptin while decreased insulin, amylin, glucokinase, thyroid stimulating hormone (TSH), triiodothyronin (T3) and thyroxin (T4) levels. High protein diet significantly restored body weight and showed significant anti-diabetic effect by reducing serum glucose and increasing serum insulin level in comparison to positive control (diabetic) group. Use of high protein diet also normalized serum amylin, leptin, GCK, T3, T4 and TSH. In sum, these results indicated the anti-hyperglycemic potential of high protein diet in alloxan-induced diabetic rat model. ©2019 PVJ. All rights reserved Key words: Amylin, leptin High protein diet Hyperglycemia Thyroid hormone To Cite This Article: Muzaffar H, Faisal MN, Khan JA and Aslam B, 2019. High protein diet improves biochemical and metabolic hormonal profile in Alloxan-induced diabetic rats. Pak Vet J, 39(2): 231-235. http://dx.doi.org/10.29261/pakvetj/2019.016 Masih, Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture Faisalabad, Pakistan for helping in animals handling and management. Authors contribution:The work is a product of the intellectual environment of the whole team; and all the members have contributed in various degrees in designing the study, developing the methodology, performing the analysis and writing the manuscript.

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Section: Discussionsupporting

confidence: 86%

High Protein Diet Improves Biochemical and Metabolic Hormonal Profile in Alloxan-Induced Diabetic Rats

Muzaffar¹

2019

PVJ

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“…Besides, W. somnifera also grows mainly in arid zones of Baluchistan, Pakistan, Afghanistan, Sri Lanka, Congo, South Africa, Egypt, Morocco, and Jordan. W. somnifera has several pharmacological activities, viz., antioxidant, antimicrobial, antifungal [4], adaptogenic [5], nootropic [6], cardioprotective [7], anticancer [8], neuroprotective [1], anticonvulsant [9], immunomodulatory [10], apoptic [11], diuretic [12], hepatoprotective [13], and anti-inflammatory features [14,15]. Pharmacological action also includes physiologic and metabolic restorations.…”

Section: Introductionmentioning

confidence: 99%

Estimation of antioxidant potential of individual components present in complex mixture ofWithania somnifera(Ashwagandha) root fraction by thin-layer chromatography-2,2-diphenyl-1-picrylhdrazyl method

Devkar

Jagtap

Katyare³

et al. 2014

Journal of Planar Chromatography – Modern TLC

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“…Other studies have confirmed similar results (Novaes et al ., ; Boudjelal et al ., ). A subsequent in vivo study conducted on rats with diabetes mellitus caused by the destruction of β‐pancreatic cells showed that 500 mg/kg per day of dry horehound extract obtained from a methanolic extract (500 g aerial part/1 × 3 L, DER 8:1) achieved significant lower blood glucose levels after 28 days (Elberry et al ., ). Insulin appeared increased in plasma and, as a result, muscle and liver glycogen synthesis boosted.…”

Section: Pharmacological Actionsmentioning

confidence: 97%

An Insight into a Blockbuster Phytomedicine;Marrubium vulgareL. Herb. More of a Myth than a Reality?

Villanueva

Alonso‐Esteban

2016

Phytother. Res.

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Aerial parts and the root of Marrubium vulgare L. (white horehound) have been traditionally used in Europe and in southern and eastern Mediterranean countries. During colonization, the plant was introduced in America to great levels of popularity because of the simplicity of its growing; it was especially popular in Mexico and Brazil, where it has been known as 'maromba', 'marroio' or 'marroio-branco'. Ethnopharmacological uses of M. vulgare include treating respiratory diseases such as acute or chronic bronchitis, colds and asthma. The plant is also used in cases where there is a lack of appetite or dyspepsia and for diagnosed type II diabetes. It has even been used for antihypertensive therapy. For decades, scientists have carried out extensive research trying to explain these and other pharmacologic actions. It is time to systematize and critically analyse the quality of results found to date. Copyright © 2016 John Wiley & Sons, Ltd.

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Methanolic extract of Marrubium vulgare ameliorates hyperglycemia and dyslipidemia in streptozotocin-induced diabetic rats

Cited by 97 publications

References 35 publications

High Protein Diet Improves Biochemical and Metabolic Hormonal Profile in Alloxan-Induced Diabetic Rats

High Protein Diet Improves Biochemical and Metabolic Hormonal Profile in Alloxan-Induced Diabetic Rats

Estimation of antioxidant potential of individual components present in complex mixture ofWithania somnifera(Ashwagandha) root fraction by thin-layer chromatography-2,2-diphenyl-1-picrylhdrazyl method

An Insight into a Blockbuster Phytomedicine;Marrubium vulgareL. Herb. More of a Myth than a Reality?

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