Methanolic extract of Cariniana rubra Gardner ex Miers stem bark negatively regulate the leukocyte migration and TNF-α and up-regulate the annexin-A1 expression

Silva, Donata Norman Paulino Brandão; Flach, Adriana; Martins, Domingos Tabajara de Oliveira; Borges, Quessi Irias; Lindote, Marcus Vitor Nunes; Zoratti, Marco Túlio Ramalho; Oliveira, Ruberlei Godinho de; Torquato, Heron Fernandes Vieira; Gazoni, Vanessa Fátima; Costa, Luiz Antonio Mendonça Alves da; Souza, Edineide Cristina Alexandre de; Silva, Felipe M. A. da; Arunachalam, Karuppusamy; Damazo, Amílcar Sabino

doi:10.1016/j.jep.2021.113778

Cited by 3 publications

(1 citation statement)

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“…Ellagitannins and triterpenoids, which are used in traditional medicine, significantly accumulate in the stem bark of Anogeissus leiocarpus DC (Akande et al., 2022). The inner stem bark decoction preparation from Cariniana rubra Gardner ex Miers is used to treat inflammatory diseases in folk medicine (Silva et al., 2021). Several novel amide alkaloids and carbazole alkaloids, such as claulansines A–J, were detected and isolated from Clausena lansium stems (Sun et al., 2021).…”

Section: Introductionmentioning

confidence: 99%

Integrated mass spectrometry imaging and single‐cell transcriptome atlas strategies provide novel insights into taxoid biosynthesis and transport in Taxus mairei stems

Hou

Zhang

et al. 2023

The Plant Journal

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SUMMARYTaxol, which is a widely used important chemotherapeutic agent, was originally isolated from Taxus stem barks. However, little is known about the precise distribution of taxoids and the transcriptional regulation of taxoid biosynthesis across Taxus stems. Here, we used MALDI‐IMS analysis to visualize the taxoid distribution across Taxus mairei stems and single‐cell RNA sequencing to generate expression profiles. A single‐cell T. mairei stem atlas was created, providing a spatial distribution pattern of Taxus stem cells. Cells were reordered using a main developmental pseudotime trajectory which provided temporal distribution patterns in Taxus stem cells. Most known taxol biosynthesis‐related genes were primarily expressed in epidermal, endodermal, and xylem parenchyma cells, which caused an uneven taxoid distribution across T. mairei stems. We developed a single‐cell strategy to screen novel transcription factors (TFs) involved in taxol biosynthesis regulation. Several TF genes, such as endodermal cell‐specific MYB47 and xylem parenchyma cell‐specific NAC2 and bHLH68, were implicated as potential regulators of taxol biosynthesis. Furthermore, an ATP‐binding cassette family transporter gene, ABCG2, was proposed as a potential taxoid transporter candidate. In summary, we generated a single‐cell Taxus stem metabolic atlas and identified molecular mechanisms underpinning the cell‐specific transcriptional regulation of the taxol biosynthesis pathway.

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Section: Introductionmentioning

confidence: 99%