Methanolic extract of African mistletoe (Viscum album) improves carbohydrate metabolism and hyperlipidemia in streptozotocin-induced diabetic rats

Adaramoye, Oluwatosin A.; Amanlou, Massoud; Habibi-Rezaei, Mehran; Pasalar, Parvin; Ali, Moosavi-Movahedi

doi:10.1016/s1995-7645(12)60073-x

Cited by 47 publications

(29 citation statements)

References 29 publications

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“…After 3 weeks of treatment with methanolic extract, a significant decrease of hyperglycaemia and a twofold higher a-amylase activity than in normal rats were observed. In addition, the research demonstrated a potential protective effect against diabetesinduced renal dysfunction and normalisation of liver enzymes and lipid profile (Adaramoye et al 2012). It has been proven that some phenolic compounds inhibit the production of advanced glycation end products which are the cause of many complications of diabetes (Choudhary et al 2010).…”

Section: Antidiabetic Propertiesmentioning

confidence: 99%

Phytochemical profile and therapeutic potential ofViscum albumL.

Nazaruk

Orlikowski²

2015

Natural Product Research

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Viscum album L., the European mistletoe, is a common species from the Viscaceae family. This evergreen hemiparasitic shrub grows on various trees and contains diverse, biologically active substances. Its chemical composition may vary depending on the time of harvest, species of the host tree and the manufacturing process. Among well-described and most active phytochemicals identified in V. album are lectins and viscotoxins, which play substantial role in cancer treatment because of their apoptotic and cytotoxic effects. Another group of compounds found in mistletoe are phenolic acids, phenylpropanoids and flavonoids with antioxidant and anti-inflammatory activities, which decrease blood pressure. Other mistletoe components include, among others, triterpenes with cytotoxic and apoptotic properties, and phytosterols, oligo- and polysaccharides. Extracts from the plant, especially aqueous, are applied in traditional and official medicine, among others in treating hypertension or arthritis. Potentially, it can also be used as a hepatoprotective or a sedative drug.

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Section: Antidiabetic Propertiesmentioning

confidence: 99%

Phytochemical profile and therapeutic potential ofViscum albumL.

Nazaruk

Orlikowski²

2015

Natural Product Research

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“…Methanol or ethanol extracts of mistletoe were reported to decrease total plasma cholesterol levels (Avci et al 2006;Ferrero et al 2007;Bachhav et al 2012) and increase HDL-C levels (Avci et al 2006;Ben et al 2006;Adaramoye et al 2012) in mice or rats. However, the effect of an aqueous extract of Korean mistletoe on the plasma levels of cholesterol and HDL-C was controversial (Kim 2006;Kim & Kim 2009).…”

Section: Kme Decreases Muscle Fatigue In Exercise-trained Micementioning

confidence: 99%

The effects of Korean mistletoe extract on endurance during exercise in mice

Lee

Kim

et al. 2014

Animal Cells and Systems

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Many investigators have screened drugs and foods for the enhancement of endurance capacity and antifatigue. Mistletoe, a semiparasitic plant on various deciduous trees, has many known biological activities, including anticancer, anti-diabetes, antioxidant, and anti-cardiovascular disease effects. In a previous study, Korean mistletoe extract (KME) was reported to increase endurance capacity in mice. However, whether the administration of KME further enhances exercise performance, when combined with exercise training, was not investigated. In this study, we demonstrate that the administration of KME decreases the level of plasma lactate dehydrogenase, parameter of tissue damage and muscle fatigue when combined with exercise training. Exercise training increases the muscular glycogen and plasma free fatty acid (FFA) level, and KME administration in sedentary mouse group increases the plasma FFA level, indicating that KME administration alters the energy resources in muscle. In addition, KME administration enhances the exercise performance in sedentary mouse group, but did not further enhance exercise performance when combined with exercise training, suggesting that KME could be an excellent mimetic of exercise.

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“…Viscum album is a native of Europe, western and southern Asia, is a semi-parasitic shrub growing on the stems of other trees (Adaramoye et al, 2012). Mistletoe is commonly found in the crowns of broadleaved trees, particularly apple, lime, hawthorn and poplar.…”

Section: Research Documentation On Antihypertensive Plantsmentioning

confidence: 99%

“…The toxic lectin, viscumin which strongly inhibits protein synthesis by inactivating the 60 S ribosomal subunit has been isolated (Olsnes et al, 1982). The antidiabetic (Adaramoye et al, 2012) and other pharmacologic activities (Gupta et al, 2012) of mistletoe have been published. Radenkovic et al (2009) reported hypotensive effect for ethanol extract of Viscum album stem at very low concentration of 3.33 Â 10 À 5 mg/kg in Wister rats which was counteracted by atropine.…”

Section: Research Documentation On Antihypertensive Plantsmentioning

confidence: 99%