Methanol leaf extract of &lt;em&gt;Actinodaphne sesquipedalis&lt;/em&gt; (Lauraceae) enhances gastric defense against ethanol-induced ulcer in rats

Omar, Hasmahzaiti; Nordin, Noraziah; Hassandarvish, Pouya; Hajrezaie, Maryam; Azizan, Ainnul Hamidah Syahadah; Fadaeinasab, Mehran; Majid, Nazia Abdul; Abdulla, Mahmood Ameen; Hashim, Najihah Mohd; Ali, Hapipah Mohd

doi:10.2147/dddt.s120564

Cited by 16 publications

(20 citation statements)

References 32 publications

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“…Our finding revealed that experimental rats fed with p-Cymene exhibited an increased concentration of PAS staining in stomach sections in comparison to the ulcer control group. Similarly, several investigators using different medicinal plants have reported an increased intensity of PAS staining in stomach sections of experimental rodents [22,56].…”

Section: Discussionmentioning

confidence: 85%

Gastroprophylactic Effects of p-Cymene in Ethanol-Induced Gastric Ulcer in Rats

et al. 2022

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The prevalence of gastric ulcers has increased in recent years, mainly because of non-steroidal anti-inflammatory drug utilization. Therefore, the current study investigates the gastroprotective effect of p-Cymene on absolute ethanol-induced acute gastric mucosal hemorrhagic lesions in rats. Thirty Sprague Dawley rats were randomly separated into five groups: normal control, ulcer control, reference, and two experimental groups. The normal and ulcer control groups were orally fed with 0.5% carboxymethylcellulose (CMC). The reference group was fed orally with 20 mg/kg omeprazole. The experimental groups were fed with 30 mg/kg and 60 mg/kg p-Cymene, respectively. After one hour, the normal group was fed with 0.5% CMC, and groups 2–5 were given absolute alcohol. After another hour all rats were sacrificed. The ulcer control group showed severe superficial hemorrhagic gastric mucosal lesions with decreased gastric mucus secretion and pH of gastric content. p-Cymene significantly reduced ethanol-induced gastric lesions, as evidenced by increased mucus and pH of gastric content, decreased ulcer area, reduced or absence of edema, and leucocyte infiltration of the subcutaneous layer. In gastric mucosal homogenate, p-Cymene displayed a significant increase in superoxide dismutase (SOD), catalase (CAT) activities, prostaglandin E2 (PGE2), and significantly reduced the malondialdehyde (MDA) level. In addition, p-Cymene increased the intensity of periodic acid–Schiff (PAS) stain of the gastric epithelium, and produced up-regulation of the HSP 70 protein and down-regulation of the Bax protein of the stomach epithelium, as well as a reduction in the levels of tumor necrotic factor-alpha and interleukin-6, while the level of interleukin-10 was increased. p-Cymene decreased the level of TNF-a and IL-6, and increased the level of IL-10. Acute toxicity with a higher dose of 500 mg/kg p-Cymene did not manifest any toxicological signs in rats and could enhance defensive mechanisms against gastric mucosal lesions. p-Cymene showed gastroprotective effects that could be attributed to its antioxidant nature, or its ability to increase mucus secretion, increase endogenous enzymes (SOD, CAT, PGE2), reduce MDA level, up-regulate HSP 70 protein, down-regulate Bax protein, and modulate inflammatory cytokines.

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Section: Discussionmentioning

confidence: 85%

Gastroprophylactic Effects of p-Cymene in Ethanol-Induced Gastric Ulcer in Rats

et al. 2022

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“…[3,28] The stomach mucosa performance barrier does not allow disgrace enzymes, for instance, pepsin effusive stomach wall. [24,29,30] Chiefly, mucus owns real slight permeability large elements, perhaps pepsin, nonetheless closely subjects, alike tension, absolute alcohol increases permeability reason liberation of vasoactive crops, and finally vascular damage. Vascular damaging enhanced alcohol success in gastric tissue and consequence disproportions removal of bicarbonate and building mucus.…”

Section: Discussionmentioning

confidence: 99%

Green Synthesis of Gold Nanoparticles Using Zingiber Officinale Rhizomes Aqueous Extract and its Gastroprotective Activity Against Ethanol-Produced Stomach Ulcer in Rodents

Shareef

Hadi

‎

et al. 2022

Cihan U Erbil SCI J

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Synthesis of gold nanoparticles exhibition wide range of bioactivities and was conventionally used for the remedy of numerous disorders. Our study aims to measure the gastroprotective effect of synthesized gold nanoparticles on absolute ethanol-induced stomach ulceration in rats. The rats were noticeably administered with two doses of gold nanoparticles (175 ppm and 350 ppm) with absolute alcohol and showed a significant improvement in the adverse effect of ethanol-produced stomach damage as confirmed by decreasing ulcer index and raising % of ulcer prevention. Increased mucus pH of stomach content reduced ulcerated portion, condensed or nonappearance of edema, and white blood cells permeation subcutaneous layer. In gastric tissue homogenate, synthesized gold nanoparticles presented a substantial increase in superoxide dismutase (SOD), catalase (CAT) actions, and a substantial lessening of malondialdehyde (MDA) amount. Besides, gold nanoparticle increases the intensity of periodic acid Schiff stained (PAS) of the gastric epithelium of the stomach. Gold nanoparticles confirmed gastro-protective effects which might be qualified to its antioxidant, increase mucus secretion, increase endogenous enzymes (SOD and CAT), and reduce MDA quantity.

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“…Glabra (Kochummen), Lauraceae family, known as "Medang payung", also demonstrated a gastroprotective effect against ethanol-induced ulcers in rats. The extract prevented gastric mucosa disruption by increasing gastric pH and mucus content and decreasing oxidative stress and inflammation, in addition to suppressing apoptosis through the upregulation of HSP-70 and downregulation of Bax protein [50].…”

Section: Gastroprotective Plants With Anti-apoptotic Effectsmentioning

confidence: 98%

Herbal Medicines in the Treatment of Dyspepsia: An Overview

et al. 2021

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This review focuses on the efficacy of herbal medicines for managing dyspepsia in humans and animals. Searches were conducted on the PubMed, Science Direct, and Medline databases, for publications in the last 3 years. In each database, the search terms used consisted of the 2 key terms describing the disorder and subtypes plus each of the terms relating to the therapy. The key terms used were “natural product” and “medicinal plant” in a cross-over with “dyspepsia” and “functional dyspepsia” (i.e., gastroprotection, Helicobacter pylori infection, prokinetic). We included all human and animal studies on the effects of herbal medicines reporting the key outcome of dyspepsia symptoms. Preclinical studies using critically validated models showed that most medicinal plants with gastroprotective action had antioxidant, anti-inflammatory, anti-apoptotic, and antisecretory effects. Moreover, several species displayed anti Helicobacter pylori and prokinetic efficacy. The data availability of controlled clinical studies is currently minimal. The use of different methodologies and the minimal number of patients raise doubts about the effects of these preparations. Only adequate clinical trials with scientifically validated methods can determine whether different herbal medicines can be used as viable alternatives to the conventional pharmacological treatments used to control dyspepsia symptoms.

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Methanol leaf extract of <em>Actinodaphne sesquipedalis</em> (Lauraceae) enhances gastric defense against ethanol-induced ulcer in rats

Cited by 16 publications

References 32 publications

Gastroprophylactic Effects of p-Cymene in Ethanol-Induced Gastric Ulcer in Rats

Gastroprophylactic Effects of p-Cymene in Ethanol-Induced Gastric Ulcer in Rats

Green Synthesis of Gold Nanoparticles Using Zingiber Officinale Rhizomes Aqueous Extract and its Gastroprotective Activity Against Ethanol-Produced Stomach Ulcer in Rodents

Herbal Medicines in the Treatment of Dyspepsia: An Overview

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