Methanol Intoxication in Patient due to the Chronic Usage of Alcohol and Cologne

Abstract

Methyl alcohol is toxic liquid that is found in substances such as mercury and antifreeze. Methanol intoxication is severe disease and may cause death. Sixty years old man was admitted to our emergency clinic complaints of impaired consciousness. In his history he is chronic alcoholic and usage of cologne. He was transferred to intensive care unit and sedatisized and curarized due to the his glasgow coma scale being under eight. 40% ethanol, folic acid, thiamine and 5% dextrose were given with nazogastric tube. Sodium bicarbonate was given due to the acidosis. The patient was discharged with complaintsts of blindness after ninth day of his admission.

Medications Damaging Ganglion Cell Layer or Optic Nerve: Pathogenesis, Diagnosis, and Treatment; (Quinine sulfate, Methanol, Carbon monoxide, Ritonavir, Fludarabine, Ethambutol, Methotrexate, Tamoxifen)

“…[28,29] Metanol toksisitesinin asıl nedeni metanolün karaciğerde alkol dehidrojenaz enzimi ile formaldehit ve formik asite dönüşümüdür. [30] Formik asit, solunum zincirinin terminal enzimi olan sitokrom c oksidaza bağlanarak mitokondriyal oksidatif fosforilasyon sürecini inhibe eder. Bu inhibisyon sonucunda gelişen reaktif oksijen radikalleri, lipidler ve deoksiribonükleik asit hücre içi temel bileşiklere zarar verir.…”