Methanol extracts of Brachystegia eurycoma and Detarium microcarpum seeds flours inhibit some key enzymes linked to the pathology and complications of type 2 diabetes in vitro

Phenolic constituents, anti-radicals, and enzymes inhibitory potentials ofBrachystegia eurycomaseeds: Effects of processing methods

“…The DPPH* and ABTS* + scavenging abilities (SC 50 : 25.10 ± 1.39 μg/mL and 1.77 ± 0.20 mmol TEAC/g, respectively) of the raw seeds observed in this study are much stronger when compared with the DPPH* and ABTS* + scavenging abilities (IC 50 : 5.05 ± 0.64 mg/mL and 29.78 ± 0.07 µmol TE/g, respectively) previously reported for methanol extract of B. eurycoma seed flour. [7] As stated earlier, variations in biotic and abiotic factors, time of sample collection, and method of sample extraction may have contributed to the difference in the free radical scavenging potential we observed, relative to the previous report. [34,35] The decrease in the DPPH* and ABTS* + scavenging potentials of the seeds due to roasting and boiling observed in this study is consistent with the findings of other researchers.…”

“…A recent in vitro study reported that the extract of B. eurycoma seeds flour inhibited some enzymes (α-amylase, α-glucosidase, and aldose reductase) that are associated with type 2 diabetes. [7] In a related study, the seeds flour was reported to be rich in flavonoids and phenolic acids and to display antidiabetic activity in type 2 diabetic rats. [1] The various health benefits of legume seeds and other plant foods have been attributed to their bioactive compounds such as flavonoids and phenolic acids.…”

Expanding the insights into the usefulness of Brachystegia eurycoma Harms: a review of its nutritional and medicinal values.

“…The plant has been used for treating microbial infections such as syphilis, dysentery, and sore throat [25]. It has also been used as a herbal remedy to control body temperature because it maintains heat within the body system [26].…”

Untitled

“…Furthermore, a recent study demonstrated that the seeds flour is rich in phenolic compounds, and exhibits antidiabetic effect in type 2 diabetic rats (Irondi et al, 2015a). In a related study, methanol extract of B. eurycoma seeds flour was reported to inhibit some enzymes relevant to type 2 diabetes, including α-amylase, α-glucosidase and aldose reductase (Irondi et al, 2015b). The increasing use of HQCF in baking food products calls for research efforts to improve its antioxidant and pasting properties, and consequently, improve its health benefits and food applications.…”