Methanol, ethyl acetate and n-hexane extracts of Tragia involucrata L. leaves exhibit anxiolytic, sedative and analgesic activity in Swiss albino mice

Islam, Md. Shofiqul; Sana, Samiron; Haque, Ehsanul; Rahman, Sheikh Mizanur; Samad, Abdus; Noman, Abdullah Al; Alam, Rahat; Rana, Sohel; Meem, Rima Islam; Mondol, Debashish; Islam, Md. Shariful; Islam, Md Torikul; Mazumder, Kishor

doi:10.1016/j.heliyon.2020.e05814

Cited by 6 publications

(1 citation statement)

References 52 publications

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“…Group 2 received L‐NAME (40 mg/kg) to induce hypertension 13 . Groups 3 and 4 received 200 mg/kg and 400 mg/kg of n‐hexane PG extract, 14 respectively. Groups 5 and 6 received l L‐NAME with 200 mg/kg and 400 mg/kg of n‐hexane PG extract, 13 respectively.…”

Section: Methodsmentioning

confidence: 99%

Effects of n‐hexane fraction of Piper guineense seed extract on N^ω‐nitro‐L‐arginine methyl ester hydrochloride‐induced hypertension in rats

Olopade,

Morakinyo,

Alao

et al. 2024

Cell Biochemistry & Function

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This study aimed to investigate the effects of the n‐hexane fraction of the ethanolic seed extract of PG (NFESEPG) on hypertension induced by Nω‐nitro‐L‐arginine methyl ester (L‐NAME) in rats. Specifically, the study examined the impact of NFESEPG on blood pressure, oxidative stress markers, NO concentration, angiotensin‐converting enzyme (ACE) and arginase activities, and cardiac biomarkers in hypertensive rats. The study involved collecting, identifying, and processing the PG plant to obtain the ethanolic seed extract. The extract was then partitioned with solvents to isolate the n‐hexane fraction. Hypertension was induced in rats by oral administration of L‐NAME for 10 days, while concurrent treatment with NFESEPG at two doses (200 and 400 mg/kg/day) was administered orally. Blood pressure was measured using a noninvasive tail‐cuff method, and various biochemical parameters were assessed. Treatment with both doses of NFESEPG significantly reduced systolic and diastolic blood pressure in L‐NAME‐induced hypertensive rats. Additionally, NFESEPG administration increased NO concentration and decreased ACE and arginase activities, malondialdehyde (MDA) levels, and cardiac biomarkers in hypertensive rats. The findings indicate that NFESEPG effectively lowered blood pressure in hypertensive rats induced by L‐NAME, potentially through mechanisms involving the modulation of oxidative stress, NO bioavailability, and cardiac biomarkers. These results suggest the therapeutic potential of NFESEPG in managing hypertension and related cardiovascular complications.

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Section: Methodsmentioning

confidence: 99%

Effects of n‐hexane fraction of Piper guineense seed extract on N^ω‐nitro‐L‐arginine methyl ester hydrochloride‐induced hypertension in rats

Olopade,

Morakinyo,

Alao

et al. 2024

Cell Biochemistry & Function

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Exposure to polystyrene nanoplastics induces an anxiolytic-like effect, changes in antipredator defensive response, and DNA damage in Swiss mice

Guimarães

Freitas²,

Mubarak³

et al. 2023

Journal of Hazardous Materials

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Synthesis of CuO, ZnO nanoparticles, and CuO-ZnO nanocomposite for enhanced photocatalytic degradation of Rhodamine B: a comparative study

Jeevarathinam,

Asharani

2024

Sci Rep

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Water pollution, arising from the presence of toxic dyes and chemicals, is a global challenge, urging the need for eco-friendly solutions in water decontamination. This study focused on the synthesis of copper oxide nanoparticles (CuO NPs), zinc oxide nanoparticles (ZnO NPs), and a bimetallic CuO-ZnO nanocomposite (CZ NC) through an environmentally friendly method employing Tragia involucrata L. leaf extract. Comprehensive analysis of structural and optical properties involved using various analytical techniques such as XRD, FT-IR, XPS, UV-DRS, PL, FE-SEM, EDAX, TEM, SAED, zeta potential, TGA, and BET. In comparison to pristine CuO and ZnO NPs, the CZ-NC demonstrated notably enhanced photocatalytic activity in the degradation of Rhodamine B dye (RhB). The optimum conditions for RhB degradation were found to be a pH of 9 and a catalyst dosage of 1 mg/mL for a concentration of 10 ppm. Under these conditions, CuO NPs, ZnO NPs, and CZ-NC demonstrated high efficiencies of 78%, 83%, and 96.1% respectively over 105 min. Through LC-HRMS, the identification of degradation products offered valuable insights into the pathway of photocatalytic degradation. Furthermore, toxicity analysis of intermediates, conducted through ECOSAR software, indicated the formation of non-toxic by-products (ChV/LC50/EC50 > 100) after the completion of the reaction. Furthermore, the recycled catalysts exhibited sustained stability for up to 4 cycles, with only a minor decrease in activity of up to 6.8%. This confirms their catalytic efficacy in purifying polluted water. This research significantly contributes to the progress of environmentally friendly nanocomposites, enhancing their efficacy in the realm of environmental remediation.

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Methanol, ethyl acetate and n-hexane extracts of Tragia involucrata L. leaves exhibit anxiolytic, sedative and analgesic activity in Swiss albino mice

Cited by 6 publications

References 52 publications

Effects of n‐hexane fraction of Piper guineense seed extract on N^ω‐nitro‐L‐arginine methyl ester hydrochloride‐induced hypertension in rats

Effects of n‐hexane fraction of Piper guineense seed extract on N^ω‐nitro‐L‐arginine methyl ester hydrochloride‐induced hypertension in rats

Exposure to polystyrene nanoplastics induces an anxiolytic-like effect, changes in antipredator defensive response, and DNA damage in Swiss mice

Synthesis of CuO, ZnO nanoparticles, and CuO-ZnO nanocomposite for enhanced photocatalytic degradation of Rhodamine B: a comparative study

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Methanol, ethyl acetate and n-hexane extracts of Tragia involucrata L. leaves exhibit anxiolytic, sedative and analgesic activity in Swiss albino mice

Cited by 6 publications

References 52 publications

Effects of n‐hexane fraction of Piper guineense seed extract on Nω‐nitro‐L‐arginine methyl ester hydrochloride‐induced hypertension in rats

Effects of n‐hexane fraction of Piper guineense seed extract on Nω‐nitro‐L‐arginine methyl ester hydrochloride‐induced hypertension in rats

Exposure to polystyrene nanoplastics induces an anxiolytic-like effect, changes in antipredator defensive response, and DNA damage in Swiss mice

Synthesis of CuO, ZnO nanoparticles, and CuO-ZnO nanocomposite for enhanced photocatalytic degradation of Rhodamine B: a comparative study

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Product

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Effects of n‐hexane fraction of Piper guineense seed extract on N^ω‐nitro‐L‐arginine methyl ester hydrochloride‐induced hypertension in rats

Effects of n‐hexane fraction of Piper guineense seed extract on N^ω‐nitro‐L‐arginine methyl ester hydrochloride‐induced hypertension in rats