Methanol elimination in non-alcoholics: inter- and intraindividual variation

Laboratory Tests for Acute Alcohol Consumption: Results of the WHO/ISBRA Study on State and Trait Markers of Alcohol Use and Dependence

“…This indicates that when alcohol consumption was discontinued, methanol and 5HTOL/5HIAA levels returned to endogenous concentrations in the course of 2 days. In this respect, the elimination kinetics of methanol and 5HTOL/5HIAA are seemingly not different in heavy drinkers compared with light/moderate consumers, which agrees with previous observations (Haffner et al, 1997b;Helander et al, 1996a).…”

Biochemical pathways generating post-mortem volatile compounds co-detected during forensic ethanol analyses

“…The microbial production of methanol (and formaldehyde) is not supported by the provided biochemical data although it has been detected in post-mortem cases [5] and in living subjects [137,140]. The presence of 2-butanol and butanone in post-mortem cases (reported in [125,137]) should also not considered a result of microbial activity.…”

“…In cases concerning chronic alcoholics and diabetics whose death was attributed to alcoholic ketoacidosis has been also reported the presence of various volatiles [132,133]. Furthermore, volatiles have been detected in the blood of living subjects either after the consumption of alcoholic beverages [134][135][136][137] or as products of metabolic processes in diabetic patients or healthy controls [115,134,[137][138][139][140]. In the blood of drunk drivers which had BAC > 0.46 g/L were found ethyl acetate, methanol, 2-propanol, acetone, 2-butanol, butanone and 1-propanol [137].…”

Aliphatic alcohol contaminants of illegally produced spirits inhibit phagocytosis by human granulocytes

“…Compared to ethanol, they had more pronounced suppressive effects on phagocytosis. Furthermore, elimination of higher alcohols from the blood is slower than that of ethanol so they can exert their inhibitory effects for a longer period [36][37][38] . Therefore, when combined with ethanol they may reduce the ability of granulocytes to phagocytose pathogenic microorganisms at toxicologically relevant concentrations in episodic heavy drinkers, and especially in binge drinkers.…”