Methanogens in Human Health and Disease

Pimentel, Mark; Gunsalus, Robert P.; Rao, Satish S.; Zhang, Husen

doi:10.1038/ajgsup.2012.6

Cited by 69 publications

(61 citation statements)

References 41 publications

(33 reference statements)

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“…Methanogenic archaea compose an important component of the microorganisms living in human and animal guts, where they use dihydrogen as reductant to produce CH 4 [ 181 ]. In humans, Methanobrevibacter smithii is the main actor of the methanogen population.…”

Section: Infl Uence Of Nickel Availability On Gut's Microfl Oramentioning

confidence: 99%

Nickel and Human Health

Zambelli

Ciurli

2013

Metal Ions in Life Sciences

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This review focuses on the impact of nickel on human health. In particular, the dual nature of nickel as an essential as well as toxic element in nature is described, and the main forms of nickel that can come in contact with living systems from natural sources and anthropogenic activities are discussed. Concomitantly, the main routes of nickel uptake and transport in humans are covered, and the potential dangers that nickel exposure can represent for health are described. In particular, the insurgence of nickel-derived allergies, nickel-induced carcinogenesis as well as infectious diseases caused by human pathogens that rely on nickel-based enzymes to colonize the host are reviewed at different levels, from their macroscopic aspects on human health to the molecular mechanisms underlying these points. Finally, the importance of nickel as a beneficial element for human health, especially being essential for microorganisms that colonize the human guts, is examined.

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Section: Infl Uence Of Nickel Availability On Gut's Microfl Oramentioning

confidence: 99%

Nickel and Human Health

Zambelli

Ciurli

2013

Metal Ions in Life Sciences

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“…Most people pass gas 13 to 21 times a day (Diabetes et al, 2015), and these emissions tell a lot about a person's health (Pimentel et al, 2012).…”

Section: Physical Layer: Modeling the Devicementioning

confidence: 99%

“…These gases may be related to different diagnostics (Mathew et al, 2015;Pimentel et al, 2012;Tangerman, 2009;Franciosa, 1977;Hirakoba et al, 1992). We list a few in Figure 4.22.…”

Section: Physical Layer: Modeling the Devicementioning

confidence: 99%

“…-The amount of methane and hydrogen in her farts may be related to some diseases: According to the authors in (Pimentel et al, 2012), "the prevalence of methane over hydrogen in human farts may correlate with obesity, constipation and irritable bowel syndrome." If her flatulence has these characteristics, she should look for a health care provider.…”

Section: Quantified Self Approachmentioning

confidence: 99%

“…Based on the research presented in (Pimentel et al, 2012), this application will limit itself to collecting the amount of gases and, if it is the case, suggesting a diagnosis of irritable bowel syndrome.…”

Section: Quantified Self Approachmentioning

confidence: 99%

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Fiot: An Agent-Based Framework for Self-Adaptive and Self-Organizing Internet of Things Applications

NASCIMENTO¹

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A role for methanogens and methane in the regulation of GLP‐1

Laverdure

Mezouari

Carson

et al. 2017

Endocrino Diabet & Metabol

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Summary Introduction The gastrointestinal ( GI ) microbiome has emerged as a potential regulator of metabolism. However, the precise mechanisms of how microorganisms may influence physiology remain largely unknown. Interestingly, GI microorganisms, including methanogens, are localized within the same regions as the glucagon‐like peptide‐1 ( GLP ‐1) secreting L cells. GLP ‐1 plays key roles appetite and glucose regulation. Furthermore, both methane and GLP ‐1 levels are altered in obese humans with metabolic disease. We predict that high‐fat diet‐induced obesity alters the abundance of GI methanogens and that methane may play a role in the GLP ‐1 secretory response from the L cell. Methods To demonstrate this, GLP ‐1 secretion response and faecal methanogens were examined in mice given a high‐fat diet for 14 weeks. In addition, the direct effect of methane on GLP ‐1 secretion was assessed in two L‐cell models ( NCI ‐H716 and GLUT ag). Results High‐fat diet caused a significant increase in both GLP ‐1 secretion and faecal methanogen content. There was a direct correlation between GLP ‐1 secretion response and faecal methanogen levels. In L cells, methane stimulated GLP ‐1 secretion and enhanced intracellular cAMP content. Conclusion These results indicate that alterations in the methanogen communities occurring in obesity may play a vital role in directly enhancing GLP ‐1 secretion, and that methane can directly stimulate the secretion of GLP ‐1.

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Methanogens in Human Health and Disease

Cited by 69 publications

References 41 publications

Nickel and Human Health

Nickel and Human Health

Fiot: An Agent-Based Framework for Self-Adaptive and Self-Organizing Internet of Things Applications

A role for methanogens and methane in the regulation of GLP‐1

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