Methanesulfonyl Chloride

Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals

“…MsCl has not been used commonly for large-scale amide couplings. , MsCl is highly toxic, corrosive, moisture-sensitive, and a lachrymator, and these properties contribute to the challenge of handling this reagent in industrial processes. However, MsCl is relatively inexpensive and has been shown to suppress epimerization for the coupling of chiral acids…”